Table of Contents
Definitions of Thought Disorders
Formal thought disorder (formal thought disorder) can be manifested in several ways. The following are the common types or descriptors of formal thought disorder:
- Poverty of speech: The total quantity of speech is limited, resulting in short responses without details.
- The poverty of content (also known as alogia): The quantity of speech is normal, but it is vague and with high levels of abstraction (conveys little information). As a result, hardly any relevant information is obtained from the patient.
- Pressure of speech: The quantity of speech is high, and so is the rate, with possible increase in volume as well. It may be difficult to interrupt.
- Distractible speech: Maintaining a topic is difficult because of easy distractibility with any stimuli such as objects on table or wall or even interviewer’s cloth.
- Tangentiality: Partially or completely irrelevant or unrelated responses to a given question.
- Derailment (also known as loosening of association or asyndesis): The speech gets frequently and perhaps progressively, “derailed” from the main topic of discussion.
- Incoherence (also known as word salad or schizophasia): There is a major problem in the forming of sentences, with no cohesion: the normal syntax and/or semantics (i.e., rules of the language) are severely impaired. Example: “Tree way of nothing house”
- Illogicality: The sequence of thoughts that the person follows in arriving at the point may be completely impaired (although it may make sense to the person).
- Clanging: It is the association of words based on sounds without any apparent conceptual or logical connection between words, often manifesting as inappropriate and excessive rhyming or alliteration, etc. Example: “I fell down the well sell bell”
- Neologism: “new words” are created and used in place of and/or in addition to existing words.
- Word approximations: Using (old, existing) words in new or unconventional ways.
- Circumstantiality: The speech is long and includes many words and (irrelevant) details; the person takes quite long to get to the point. This differs from tangentiality in which the person never gets to the point.
- Loss of goal: There is difficulty in maintaining the point of the answer.
- Perseveration: The speech is characterized by excessive repetition of words/phrases or ideas.
- Echolalia: There is immediate or delayed repetition (parroting) of the words and phrases, usually those of the interviewer.
- Thought blocking: The speech flow gets suddenly interrupted due to a block in the thought (may last for few seconds to few minutes), and a completely new thought may then begin.
- Stilted speech: The speech is characterized by a very unusual tone of language and vocabulary, e.g., excessively formal tone or use of archaic words, etc.
- Self-reference: The speech is characterized by repeated referencing of the person to him- or herself.
While the aforementioned classification is from the point of view of the speech of the person (also known as disorganized speech), another classification attempts to categorize these conditions based on the process of thought and of speech separately.
Disorders of content and control of thought vs. disorders of stream of thought
Disorders of thought are divided into disorders of content, form, and control of thought (e.g., delusions, hallucinations, paranoia, etc.) and disorders of stream of thought (equivalent to formal thought disorders).
The latter are sub-grouped into disorders of thought of tempo (flight of ideas/tangentiality, inhibition/poverty of speech, circumstantiality, etc.) and disorders of continuity of thinking (perseveration, thought blocking, etc.). The remaining are clubbed under disorders of speech (neologism, schizophasia, etc.).
Epidemiology and Etiopathology of Thought Disorders
Although a very large-sample study on the frequency of various types of formal thought disorders is lacking, in patients with schizophrenia, the following is generally observed: the most common types of formal thought disorder (among the aforementioned eighteen) are derailment, loss of goal, poverty of content, and tangentiality. This is followed by poverty of speech, pressure of speech, illogicality, perseveration, self-reference, and incoherence, all of which are moderately common. The remaining thought-disorder symptoms are not common.
The etiology of formal thought disorder has not been established. Formal thought disorder is a disorder of the executive function, due to impairment in the syntax-semantic system required for cohesive and coherent speech, and there is some loss of access to the lexicon as well.
Diagnosis of Thought Disorders
As per DSM-5, formal thought disorder is one of the essential criteria (Criterion A) for diagnosis of brief psychotic disorder, schizophrenia, and schizophreniform disorder. Derailment and tangentiality are seen in schizoaffective disorder.
Symptoms of thought disorders
Formal thought disorder is typically associated with the psychotic range of diseases, particularly schizophrenia. However, some types are found more commonly in other (mood spectrum) diseases such as mania (especially clanging) and depression (especially the negative speech symptoms such as poverty of speech, blocking, derailment, and loss of goal).
Other conditions such as delirium and autism spectrum disorder may also present with a formal thought disorder. Circumstantiality can occur in individuals with a learning disability as well as those with obsessive personalities. Perseveration is common in individuals with organic disorders of the brain.
Whether the etiology is primarily psychiatric or secondary to an underlying medical disorder can be partly discerned from certain points during history taking. Patients with a medical disorder tend to be older and have an acute onset of the psychotic symptoms. The presence of auditory hallucinations is strongly indicative of a primary psychiatric disorder.
Mere disorganized speech should not be considered as a thought disorder, as mild abnormalities are not uncommon. The symptoms must be severe enough to affect fluid communication. The severity of each symptom (including delusional and hallucinatory symptoms) can be evaluated by rating it on a 5-point Likert scale, ranging from 0 (not present) to 4 (severe). However, rating is not essential for the diagnosis of the disorder.
In addition, recording of a sample of speech is a good strategy for both diagnosis and assessment of disease progression or treatment efficacy. While assessing thought disorder symptoms, differences arising from different language backgrounds of the patient and physician as well as from patient’s exhaustion and other mild illness must be kept in mind.
Laboratory investigations are not required for the diagnosis of psychiatric diseases. However, they should be performed to rule out common medical and drug-induced causes (see Differential Diagnoses section for details). The common tests done include complete blood count, kidney and liver function tests, thyroid assessment, tests for alcohol and other drugs such as cocaine, blood and urine cultures for infections, vitamin levels, electrolyte abnormalities, and glucose levels. Brain imaging, electroencephalogram, or other investigations are indicated if other secondary causes (e.g., demyelinating disorders) are suspected.
Differential Diagnoses of Thought Disorders
Many medical conditions can have symptoms in the psychotic spectrum:
- Anatomic (e.g., traumatic brain injury)
- Drug-induced and medication-induced psychiatric disorders (recreational drugs such as cocaine, phencyclidine, hallucinogens, amphetamines, alcohol, etc.; and medications such as corticosteroids, levodopa, etc.)
- Endocrine disorders (e.g., iatrogenic Cushing syndrome [hypercortisolism], hyper- [or hypo-] parathyroidism, adrenocortical insufficiency [Addison disease], thyroid diseases)
- Infectious diseases (e.g., neurosyphilis, HIV, cerebral abscess, encephalitis, influenza, Lyme disease, hepatitis C, Creutzfeldt–Jakob disease)
- Metabolic diseases (e.g., acute porphyrias, Wilson’s disease)
- Vitamin deficiency (e.g., vitamin B12)
- Others (e.g., systemic lupus erythematosus, delirium, hepatic and renal encephalopathies)
Differentiating between the psychiatric conditions*:
|Brief psychotic disorder||Schizophreniform disorder||Schizophrenia||Schizoaffective disorder||Psychotic mood disorder|
|Duration||1 day to 1 month||1—6 months||> 6 months (with at least 1 month of active phase symptoms)||> 6 months (accompanied by mood symptoms followed by at least 2 weeks of delusions/hallucinations without mood symptoms)||Symptoms occur only during periods of mood symptoms|
|Presence of mood disorder||Yes||–||–||Yes||Yes, predominantly|
*Careful attention should be given to the possibility that a recurrent disorder (e.g., bipolar disorder, recurrent acute exacerbations of schizophrenia) may be responsible for any recurring psychotic episodes
Treatment of Thought Disorders
Treatment of the medical disorders should aim at treating the underlying cause, which will resolve the psychiatric symptoms.
Psychotic disorders can be managed using psychotherapy, family-oriented and other social–educational therapies, and pharmacotherapy. Medications used in the pharmacological treatment of psychotic disorders (schizophreniform disorder, schizophrenia, and the like) include second-generation antipsychotics such as aripiprazole, asenapine, iloperidone, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, and ziprasidone. In refractory cases, electroconvulsive therapy may be tried.
Review Questions of Thought Disorders
The answers can be found below the references.
1. Which of the following is not a type of disorganized thought disorder?
A. Thought insertion
B. Thought blocking
C. Thought derailment
2. Which of the following type of formal thought disorder is a negative symptom?
A. Pressure of speech
B. Distractible speech
C. Thought blocking
E. Word approximation
3. Thought blocking is not seen in patients with which of the following conditions?
C. Brief psychotic episode
E. Schizoaffective disorder