Cardiac glycosides are a class of drugs reversibly inhibiting the sodium-potassium ATPase pump Pump ACES and RUSH: Resuscitation Ultrasound Protocols in myocardial cells and increasing vagal tone, which results in increased cardiac contractility and slowed conduction through the atrioventricular node Atrioventricular node A small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus. It gives rise to the atrioventricular bundle of the conduction system of the heart. Heart: Anatomy. Digoxin is the only medically used drug in the cardiac glycoside class. Digoxin can be used for rate control in atrial fibrillation Atrial fibrillation Atrial fibrillation (AF or Afib) is a supraventricular tachyarrhythmia and the most common kind of arrhythmia. It is caused by rapid, uncontrolled atrial contractions and uncoordinated ventricular responses. Atrial Fibrillation/flutter and for systolic heart failure Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (ventricular dysfunction), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as myocardial infarction. Total Anomalous Pulmonary Venous Return (TAPVR). However, the medication needs to be used with caution due to a very narrow therapeutic window Therapeutic Window Dosage Calculation. Digoxin toxicity Toxicity Dosage Calculation can result in life-threatening arrhythmias as well as GI and neurologic symptoms; an antidote Antidote An antidote is a substance that counteracts poisoning or toxicity. Substances that can cause poisoning include heavy metals (from occupation, treatments, or diet), alcohols, environmental toxins, and medications. Antidotes of Common Poisonings is available.
Last updated: Sep 1, 2022
Digoxin is the prototype drug of the cardiac glycoside class and the only drug in the class used for medicinal purposes.
Digoxin is indicated for rate control when other therapies are ineffective or contraindicated:
Drug interactions may lead to:
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