Donovanosis (also known as granuloma inguinale) is an STD caused by Klebsiella granulomatis and is mainly seen in tropical regions. The condition is characterized by chronic, progressive, ulcerating disease mostly affecting the genital region. The patient presents with painless nodular lesions that ulcerate, commonly with a "beefy-red" base. There is no associated inguinal lymphadenopathy Inguinal Lymphadenopathy Lymphadenopathy. Diagnosis is via history, clinical findings, and tissue smear or biopsy Biopsy Removal and pathologic examination of specimens from the living body. Ewing Sarcoma showing Donovan bodies, which are intracellular inclusion bodies inside macrophages Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood monocytes. Main types are peritoneal macrophages; alveolar macrophages; histiocytes; kupffer cells of the liver; and osteoclasts. They may further differentiate within chronic inflammatory lesions to epithelioid cells or may fuse to form foreign body giant cells or langhans giant cells. Innate Immunity: Phagocytes and Antigen Presentation. Treatment is with a prolonged course of antibiotics until lesions are healed, with monitoring for recurrence.
Last updated: Mar 10, 2021
Donovanosis, or granuloma inguinale, is an STD STD Sexually transmitted diseases (STDs) are infections that spread either by vaginal intercourse, anal sex, or oral sex. Symptoms and signs may include vaginal discharge, penile discharge, dysuria, skin lesions (e.g., warts, ulcers) on or around the genitals, and pelvic pain. Some infections can lead to infertility and chronic debilitating disease. Sexually Transmitted Infections (STIs) characterized by chronic progressive ulcers affecting the genital region.
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