Syphilis is a bacterial infection caused by the spirochete Spirochete Treponema is a gram-negative, microaerophilic spirochete. Owing to its very thin structure, it is not easily seen on Gram stain, but can be visualized using dark-field microscopy. This spirochete contains endoflagella, which allow for a characteristic corkscrew movement. Treponema Treponema pallidum Treponema pallidum The causative agent of venereal and non-venereal syphilis as well as yaws. Treponema subspecies pallidum (T. pallidum), which is usually spread through sexual contact. Syphilis has 4 clinical stages: primary, secondary, latent, and tertiary. Primary syphilis begins with a chancre, a painless ulcer on the genitals. Progression to secondary syphilis manifests as a generalized maculopapular Maculopapular Dermatologic Examination rash Rash Rocky Mountain Spotted Fever, which includes the palms and soles. The development of tertiary syphilis can cause severe neurologic (neurosyphilis), cardiovascular, and/or gummatous disease. The diagnosis is through both treponemal and nontreponemal testing. Penicillin Penicillin Rheumatic Fever G is the antibiotic of choice. The duration of management varies based on the stage of the disease.
Last updated: Nov 17, 2022
Syphilis is a multistage disease. Patients Patients Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. Clinician–Patient Relationship can present at any stage and infected individuals may not exhibit symptoms for years.
It is difficult to diagnose syphilis. However, specific labs and the correlation Correlation Determination of whether or not two variables are correlated. This means to study whether an increase or decrease in one variable corresponds to an increase or decrease in the other variable. Causality, Validity, and Reliability of history and examination results can lead to a diagnosis.
Definitive tests using obtained specimens (such as mucosal lesions). However, use is limited since the tests are not routinely available.
For primary, secondary, or early-latent syphilis, the following antibiotics can be used:
For late-latent syphilis, tertiary syphilis, or syphilis of unknown duration, the following regimen is used:
Sign up now and get free access to Lecturio with concept pages, medical videos, and questions for your medical education.
Lecturio Premium gives you full access to all content & features
Verify your email now to get a free trial.
Lecturio Premium gives you full access to all contents and features—including Lecturio’s Qbank with up-to-date board-style questions.