Fibroadenomas are the most common benign tumor Tumor Inflammation of the female breast and the most common breast tumor Tumor Inflammation in adolescent and young women. The tumors are well-circumscribed, mobile, and unencapsulated, with a rubbery or firm consistency Consistency Dermatologic Examination. Fibroadenomas are hormonally responsive, so they may increase in size during pregnancy Pregnancy The status during which female mammals carry their developing young (embryos or fetuses) in utero before birth, beginning from fertilization to birth. Pregnancy: Diagnosis, Physiology, and Care and usually regress after menopause Menopause Menopause is a physiologic process in women characterized by the permanent cessation of menstruation that occurs after the loss of ovarian activity. Menopause can only be diagnosed retrospectively, after 12 months without menstrual bleeding. Menopause. Histologically, fibroadenomas are composed of a biphasic proliferation of both glandular and stromal elements. Fibroadenomas are associated with a slightly increased risk of carcinoma, with a somewhat higher risk if so-called “complex” features are present. Diagnosis is based on physical findings and ultrasonography. Management is based on regular Regular Insulin checkups to monitor growth.
Last updated: 16 May, 2022
A: Breast ultrasonography in a 25-year-old patient shows a homogenous,
hypoechoic
Hypoechoic
A structure that produces a low-amplitude echo (darker grays)
Ultrasound (Sonography), gently lobulated lesion (arrow), suggestive of a fibroadenoma.
B: Ultrasonography shows a degenerating fibroadenoma (arrow) with coarse calcifications (arrowhead) and posterior shadowing from the calcific foci.
Preoperative imaging, histology, absoption- and phase-contrast CT:
Preoperative ultrasonography (A) with typical benign imaging characteristics of the fibroadenoma (
FA
FA
Inhaled Anesthetics) (oval form, smooth margins, posterior enhancement);
preoperative craniocaudal (B) and mediolateral oblique (C)
mammography
Mammography
Radiographic examination of the breast.
Breast Cancer Screening projections show the fibroadenoma (
FA
FA
Inhaled Anesthetics) partially hidden within the dense breast parenchyma (BP) (ACR IV).
Representative histological slice (D) and corresponding absorption- (E) and phase-contrast CT (F) image. The black sharp lines in the corners of (E) and (F) correspond to the walls of the plastic container. The ducts are artificially torn open in (D) due to cutting and staining procedures.
Preoperative mediolateral-oblique (A) and craniocaudal (B)
mammogram
Mammogram
Fibrocystic Change and ultrasonography (C) show the fibroadenoma (
FA
FA
Inhaled Anesthetics).
A representative histological slice (D) shows the
FA
FA
Inhaled Anesthetics, surrounded by
adipose tissue
Adipose tissue
Adipose tissue is a specialized type of connective tissue that has both structural and highly complex metabolic functions, including energy storage, glucose homeostasis, and a multitude of endocrine capabilities. There are three types of adipose tissue, white adipose tissue, brown adipose tissue, and beige or “brite” adipose tissue, which is a transitional form.
Adipose Tissue: Histology (AT) and breast parenchyma (BP).
(D) The black rectangle shows a zoomed view of a polygonal sclerotic frame filled with basophilic branched ducts; 1 linear duct is indicated by the arrow.
Microscopic examination of the intraductal fibroadenoma or intraductal phyllodes
tumor
Tumor
Inflammation of the breast
A: Low-power view shows that its polypoid parts are composed of leaf-like processes with a hypocellular and prominent myxoid stroma protruding into
cystic
Cystic
Fibrocystic Change spaces, reminiscent of intracanalicular type fibroadenoma or benign phyllodes
tumor
Tumor
Inflammation features (H&E stains). Bar = 200 μm.
B: In some areas, there are foci of a typical intracanalicular variant of fibroadenoma, in which duct lumens are compressed by the proliferating myxoid stroma (H&E stains). Bar = 200 μm.
C: On high-power view, those stromal cells show no significant
atypia
Atypia
Fibrocystic Change, but the covering
hyperplastic
Hyperplastic
Colon Polyps epithelial components are also bland looking in 2 cell layers. Mitotic figures are very rarely seen (H&E stains). Bar = 200 μm.
D: In others, tiny foci of benign intraductal
papilloma
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells.
Cowden Syndrome with characteristic delicate fibrovascular stalks are rarely seen (H&E stains). Bar = 100 μm.
The following conditions are differential diagnoses of fibroadenomas: