Breast cancer is a disease characterized by malignant transformation Transformation Change brought about to an organism's genetic composition by unidirectional transfer (transfection; transduction, genetic; conjugation, genetic, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome. Bacteriology of the epithelial cells of the breast. Breast cancer is the most common form of cancer and 2nd most common cause of cancer-related death among women. Genetic factors, age, and hormonal and environmental influence contribute to the progression of the disease. The most common histologic type is infiltrating ductal carcinoma, which is > 75% of all breast cancers. Screening Screening Preoperative Care mammography Mammography Radiographic examination of the breast. Breast Cancer Screening is recommended for early disease detection. Diagnosis is by core needle biopsy Core Needle Biopsy Fibrocystic Change, with biologic factors determined by immunohistochemical testing. Surgery, systemic treatment ( chemotherapy Chemotherapy Osteosarcoma, biologic therapy, endocrine therapy), and radiation Radiation Emission or propagation of acoustic waves (sound), electromagnetic energy waves (such as light; radio waves; gamma rays; or x-rays), or a stream of subatomic particles (such as electrons; neutrons; protons; or alpha particles). Osteosarcoma therapy (RT) are part of the early-stage and locally advanced disease management. In metastatic breast cancer, systemic treatment is utilized with palliative measures.
Last updated: Jul 25, 2022
Unmodifiable factors that increase the risk:
Modifiable risk factors:
“BReast- CA CA Condylomata acuminata are a clinical manifestation of genital HPV infection. Condylomata acuminata are described as raised, pearly, flesh-colored, papular, cauliflower-like lesions seen in the anogenital region that may cause itching, pain, or bleeding. Condylomata Acuminata (Genital Warts)ncer 1 and 2” = Mutated genes Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. DNA Types and Structure are the BRCA1 and BRCA2 genes Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. DNA Types and Structure.
Other clinical forms:
Based on expression of:
In areas with established breast cancer screening Breast cancer screening Breast cancer is the most common cancer in women and the 2nd-leading cause of cancer-related deaths in women in the United States. Early detection and improved pathology-specific treatments have resulted in a decrease in death rates. Breast Cancer Screening: Most cases of cancer are diagnosed by having an abnormal mammogram Mammogram Fibrocystic Change.
|Presentation||Unifocal Unifocal Retinoblastoma||Multifocal Multifocal Retinoblastoma|
|Risk of invasive breast cancer||Higher||Lower|
|Location of cancer||Ipsilateral breast||Ipsilateral or contralateral|
|Tumor Tumor Inflammation stage||Description|
|Tx||Primary tumor Tumor Inflammation unable to be assessed|
|T0||No evidence of primary tumor Tumor Inflammation|
|T1||≤ 20-mm tumor Tumor Inflammation in greatest dimension|
|T2||> 20-mm but ≤ 50-mm tumor Tumor Inflammation in greatest dimension|
|T3 T3 A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5′ position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly t3. Thyroid Hormones||> 50-mm tumor Tumor Inflammation in greatest dimension|
|T4 T4 The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. Thyroid Hormones||Tumor Tumor Inflammation of any size, with direct extension Extension Examination of the Upper Limbs to the chest wall Chest wall The chest wall consists of skin, fat, muscles, bones, and cartilage. The bony structure of the chest wall is composed of the ribs, sternum, and thoracic vertebrae. The chest wall serves as armor for the vital intrathoracic organs and provides the stability necessary for the movement of the shoulders and arms. Chest Wall: Anatomy and/or skin Skin The skin, also referred to as the integumentary system, is the largest organ of the body. The skin is primarily composed of the epidermis (outer layer) and dermis (deep layer). The epidermis is primarily composed of keratinocytes that undergo rapid turnover, while the dermis contains dense layers of connective tissue. Skin: Structure and Functions ( ulceration Ulceration Corneal Abrasions, Erosion, and Ulcers or macroscopic nodules)|
|cNX||Regional LNs cannot be assessed.|
|cN0||No regional LN metastases|
|cN1||Metastasis Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Grading, Staging, and Metastasis to movable ipsilateral level I, II axillary LNs|
|Metastasis Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Grading, Staging, and Metastasis||Description|
|M0||No evidence of distant metastasis Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Grading, Staging, and Metastasis (clinical or radiographic)|
|M1||Detectable metastasis Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Grading, Staging, and Metastasis|
|Stage||Substages||Tumor Tumor Inflammation||Node||Metastasis Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. Grading, Staging, and Metastasis|
|IV||Any T||Any N||M1|
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