Basal cell Basal Cell Erythema Multiforme carcinoma is the most common skin Skin The skin, also referred to as the integumentary system, is the largest organ of the body. The skin is primarily composed of the epidermis (outer layer) and dermis (deep layer). The epidermis is primarily composed of keratinocytes that undergo rapid turnover, while the dermis contains dense layers of connective tissue. Skin: Structure and Functions malignancy Malignancy Hemothorax. This cancer arises from the basal layer of the epidermis Epidermis The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of epithelium: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis). Skin: Structure and Functions. The lesions most commonly appear on the face as pearly nodules, often with telangiectatic blood vessels and ulceration Ulceration Corneal Abrasions, Erosion, and Ulcers in elderly individuals. Diagnosis is established by tissue biopsy Biopsy Removal and pathologic examination of specimens from the living body. Ewing Sarcoma. Despite having low metastatic potential, basal cell carcinoma should be treated adequately because it is locally aggressive and destructive to tissues. Complete surgical excision is the main treatment method. Long-term prognosis Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Non-Hodgkin Lymphomas is excellent with adequate management.
Last updated: 10 Mar, 2022
Basal cell Basal Cell Erythema Multiforme carcinoma is a skin Skin The skin, also referred to as the integumentary system, is the largest organ of the body. The skin is primarily composed of the epidermis (outer layer) and dermis (deep layer). The epidermis is primarily composed of keratinocytes that undergo rapid turnover, while the dermis contains dense layers of connective tissue. Skin: Structure and Functions cancer arising from the basal layer of epidermis Epidermis The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of epithelium: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis). Skin: Structure and Functions and its appendages.
Type | Frequency | Histology | Clinical presentation Presentation The position or orientation of the fetus at near term or during obstetric labor, determined by its relation to the spine of the mother and the birth canal. The normal position is a vertical, cephalic presentation with the fetal vertex flexed on the neck. Normal and Abnormal Labor |
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Nodular basal cell carcinoma | 80% |
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Superficial basal cell carcinoma | 15% | Atypical basaloid tumors arise as buds from the epidermis Epidermis The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of epithelium: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis). Skin: Structure and Functions |
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Morpheaform basal cell carcinoma | 5%–10% |
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Nodular basal cell carcinoma of the
nose
Nose
The nose is the human body’s primary organ of smell and functions as part of the upper respiratory system. The nose may be best known for inhaling oxygen and exhaling carbon dioxide, but it also contributes to other important functions, such as tasting. The anatomy of the nose can be divided into the external nose and the nasal cavity.
Nose and Nasal Cavity: Anatomy:
Pearly
nodule
Nodule
Chalazion with visible telangiectatic vessels
Superficial basal cell carcinoma:
A pink, scaly lesion on the
skin
Skin
The skin, also referred to as the integumentary system, is the largest organ of the body. The skin is primarily composed of the epidermis (outer layer) and dermis (deep layer). The epidermis is primarily composed of keratinocytes that undergo rapid turnover, while the dermis contains dense layers of connective tissue.
Skin: Structure and Functions
Morpheaform basal cell carcinoma:
Sclerotic, partially reddish
plaque
Plaque
Primary Skin Lesions with irregular borders and crusting in the center
Nodular basal cell carcinoma:
Palisading
keratinocytes
Keratinocytes
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
Skin: Structure and Functions in nodular basal cell cancer
Nodular basal cell carcinoma:
Micrograph of a nodular basal cell cancer with a cleft
Micrograph of superficial basal cell carcinoma:
Palisading
tumor
Tumor
Inflammation cells
budding
Budding
Mycology off of the
epidermis
Epidermis
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of epithelium: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
Skin: Structure and Functions
Morpheaform basal-cell carcinoma: Cords of tumor Tumor Inflammation cells grow into the dermis Dermis A layer of vascularized connective tissue underneath the epidermis. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are sweat glands; hair follicles; and sebaceous glands. Skin: Structure and Functions (infiltrative)
Image: “Morpheaform basal-cell carcinoma” by Masahiro Nakayama, Keiji Tabuchi, Yasuhiro Nakamura, and Akira Hara. License: CC BY 4.0History:
Physical exam:
Dermoscopy Dermoscopy A noninvasive technique that enables direct microscopic examination of the surface and architecture of the skin. Seborrheic Keratosis:
Biopsy Biopsy Removal and pathologic examination of specimens from the living body. Ewing Sarcoma:
Assess risk of recurrence:
Surgery:
Alternative therapies:
Therapy for advanced disease: