The embryological development of craniofacial structures is an intricate sequential Sequential Computed Tomography (CT) process involving tissue growth and directed cell apoptosis Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, I.e., DNA fragmentation. It is genetically-programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Ischemic Cell Damage. Disruption of any step in this process may result in the formation of a cleft lip alone or in combination with a cleft palate Palate The palate is the structure that forms the roof of the mouth and floor of the nasal cavity. This structure is divided into soft and hard palates. Palate: Anatomy. As the most common craniofacial malformation of the newborn Newborn An infant during the first 28 days after birth. Physical Examination of the Newborn, the diagnosis of a cleft is clinical and usually apparent at birth. The type and severity of the defect cause various degrees of difficulty with speech development, feeding, swallowing Swallowing The act of taking solids and liquids into the gastrointestinal tract through the mouth and throat. Gastrointestinal Motility, tooth eruption, and cosmetic issues. Ultimate correction is through surgical repair.
Last updated: Sep 22, 2022
The prevalence Prevalence The total number of cases of a given disease in a specified population at a designated time. It is differentiated from incidence, which refers to the number of new cases in the population at a given time. Measures of Disease Frequency of orofacial clefts varies widely around the world. The following data are specific to the United States.
All clefts arise from errors in the embryological development of the face.
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