Wilms tumor Tumor Inflammation is a malignancy Malignancy Hemothorax caused by proliferation of metanephric blastema in the kidneys Kidneys The kidneys are a pair of bean-shaped organs located retroperitoneally against the posterior wall of the abdomen on either side of the spine. As part of the urinary tract, the kidneys are responsible for blood filtration and excretion of water-soluble waste in the urine. Kidneys: Anatomy and is the most common renal malignancy Malignancy Hemothorax in children. Wilms tumor Tumor Inflammation usually arises sporadically, but it can also occur as a result of a specific congenital Congenital Chorioretinitis anomaly like WAGR (Wilms tumor Tumor Inflammation, aniridia, genitourinary abnormalities, and mental retardation) syndrome, Denys–Drash syndrome Denys–Drash Syndrome Nephrotic Syndrome in Children, or Beckwith–Wiedemann syndrome. Wilms tumor Tumor Inflammation commonly presents as a firm, nontender, smooth mass Mass Three-dimensional lesion that occupies a space within the breast Imaging of the Breast that does not cross the midline. Wilms tumor Tumor Inflammation can also rarely present with abdominal pain Abdominal Pain Acute Abdomen, hematuria Hematuria Presence of blood in the urine. Renal Cell Carcinoma, and/or hypertension Hypertension Hypertension, or high blood pressure, is a common disease that manifests as elevated systemic arterial pressures. Hypertension is most often asymptomatic and is found incidentally as part of a routine physical examination or during triage for an unrelated medical encounter. Hypertension. The malignancy Malignancy Hemothorax is diagnosed with abdominal ultrasonography and histopathologic studies (from biopsy Biopsy Removal and pathologic examination of specimens from the living body. Ewing Sarcoma or resection). Wilms tumor Tumor Inflammation is treated with multimodal therapy (surgery, chemotherapy Chemotherapy Osteosarcoma, radiation Radiation Emission or propagation of acoustic waves (sound), electromagnetic energy waves (such as light; radio waves; gamma rays; or x-rays), or a stream of subatomic particles (such as electrons; neutrons; protons; or alpha particles). Osteosarcoma). Influenced by patient age, molecular markers, and pathologic findings, prognosis Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Non-Hodgkin Lymphomas is favorable overall, with 5-year survival rates approaching 90%.
Last updated: 16 Apr, 2021
Wilms
tumor
Tumor
Inflammation:
Note the prominent septa subdividing the sectioned surface and the protrusion of
tumor
Tumor
Inflammation into the
renal pelvis
Renal pelvis
Kidneys: Anatomy, resembling botryoid rhabdomyosarcoma.
Serial abdominal ultrasonography for those at risk for Wilms tumor Tumor Inflammation:
Abdominal ultrasound revealing left-sided Wilms tumor Tumor Inflammation in 4-year-old boy
Image: “ Neuroblastoma Neuroblastoma Neuroblastoma is a malignancy that arises from the neural crest cell derivatives along the sympathetic chain (neuroblasts) and is most commonly located in the adrenal medulla. The tumor often presents in childhood with a flank mass that crosses the midline. Neuroblastoma and nephroblastoma: a radiological review” by Dumba M, Jawad N, McHugh K. License: CC BY 4.0MRI of Wilms tumor Tumor Inflammation: 4-year-old girl with bilateral Wilms’ tumor Tumor Inflammation, more cystic Cystic Fibrocystic Change on the left
Image: “Figure 11” by Dumba, M. et al AL Amyloidosis. License: CC BY 4.0Wilms tumor Tumor Inflammation exhibiting an epithelial component (A), stromal component (B), and small areas of blastema (C)
Image: “Wilms tumor Tumor Inflammation in a 37-year-old” by Thevendran G, Farne HA HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia, Kaisary AV. License: CC BY 2.0Histopathologic examination from biopsy Biopsy Removal and pathologic examination of specimens from the living body. Ewing Sarcoma of Wilms tumor Tumor Inflammation with anaplasia
Image: “Wilms tumour with anaplasia” by van den Heuvel-Eibrink, MM MM Multiple myeloma (MM) is a malignant condition of plasma cells (activated B lymphocytes) primarily seen in the elderly. Monoclonal proliferation of plasma cells results in cytokine-driven osteoclastic activity and excessive secretion of IgG antibodies. Multiple Myeloma. License: CC BY 4.0From National Wilms Tumor Tumor Inflammation Study (NWTS)/Children’s Oncology Group (COG):
Recommendations based on the NWTS/COG trials: