Table of Contents
- Definition of Laxative Abuse
- Epidemiology of Laxative Abuse
- Etiology of Laxative Abuse
- Pathology and Pathophysiology of Laxative Abuse
- Symptoms of Laxative Abuse
- Diagnosis of Laxative Abuse
- Differential Diagnoses of Laxative Abuse
- Therapy of Laxative Abuse
- Progression and Prognosis of Laxative Abuse
- Review Questions
Definition of Laxative Abuse
Laxative abuse describes the chronic overuse of laxatives for purposes other than relieving constipation.
Epidemiology of Laxative Abuse
Spread of laxative abuse
About 4 % of the general population abuse laxatives. Higher rates of abuse are found with eating disorders.
Etiology of Laxative Abuse
Causes of laxative abuse
Laxative abuse is defined as using laxatives for purposes other than to relieve constipation. Constipation is medically defined as having less than three bowel movements per week, any number above this is within the range of normal and should not be treated. They are frequently abused to lose weight, regulate bowel movements, or in the mental illness of factitious disorder.
Many different people try to lose weight with laxatives. People suffering from anorexia or bulimia frequently use excess amounts of laxatives. Also, collegiate athletes, especially wrestlers, will use them to reach a weight goal. Patients suffering from factitious disorder will use laxatives to develop diarrhea and appear ill and receive sympathy and attention from the medical community, friends, and family. This is called tertiary gain.
Prolonged laxative use may be appropriate under some circumstances. Constipation is a very common condition in the developed world. Approximately 50 % of the elderly suffer from constipation and require long term treatment which may include prolonged laxative treatment.
Pathology and Pathophysiology of Laxative Abuse
There are many types of laxatives, each with unique mechanisms of action. Oral administration requires several hours to take effect while suppositories work faster (about an hour).
- Emollients: Also known as stool softeners. These laxatives act as surfactants to increase the moisture of the stool, easing it through the intestine at a faster rate
- Lubricant: Different oils, such as mineral oil and castor oil coat the intestinal mucosa and prevent water absorption. This increases the moisture content of the stool
- Hyperosmotic agents and saline laxatives: These substances are not absorbed by the GI tract. They absorb available water in the lumen to increase the moisture content of the stool
- Stimulants: These are strong laxatives that stimulate intestinal nerves to increase peristaltic action. Excess use of these laxatives may result in changes to the GI tract
Symptoms of Laxative Abuse
Signs of laxative abuse
Laxative abuse may present without symptoms. The underlying drive to abuse laxatives may present first such as an eating disorder of factitious disorder. Signs and symptoms of abuse and misuse include alternating diarrhea and constipation.
Diagnosis of Laxative Abuse
Laxative diagnosis requires careful analysis of the history and physical for patterns. Pseudomelanosis coli is a finding on colonoscopy or biopsy that may indicate prolonged laxative use, especially the plant derived anthraquinone type. Over use of this type of laxative results in mucosal damage and apoptosis of the most superficial cells in the gut.Cell debris is collected by macrophages which result in brown, lipofuscin staining of the large intestine walls.
Differential Diagnoses of Laxative Abuse
Clinical pictures similar to laxative abuse
All of these conditions involve a patient complaining of diarrhea. Careful evaluation of the patient’s history and physical may provide evidence to direct you towards the diagnosis of laxative abuse.
Therapy of Laxative Abuse
Treatment of laxative abuse
The most effective treatments of laxative abuse are to treat the underlying condition, educating the patient, and encouraging the cessation of the laxatives. Treating eating disorders and factitious disorders requires psychotherapy (cognitive-behavioral or family therapy).
Progression and Prognosis of Laxative Abuse
Excessive use of laxatives can result in many complications depending on the severity of abuse. Nutrient and electrolyte absorption is reduced as transit times through the small and large intestines are reduced. This may result in hypokalemia and metabolic acidosis. There are high concentrations of potassium and bicarbonate in GI secretions that are not reabsorbed properly with laxative use. Minor hypokalemia results in muscle weakness and paralysis while a severe case may result in cardiovascular and renal complications.
Most complications associated with laxative abuse, including pseudomelanosis coli, loss of large intestine haustra, hypokalemia, and metabolic acidosis, are reversible with cessation of laxative use.
The correct answers can be found below the references.
1. Which is an example of laxative abuse?
- To relieve constipation
- To prepare for a colonoscopy
- To lose weight
2. Which electrolytes are expected to be low in patients who chronically abuse laxatives?
- Metabolic alkalosis
3. What histological changes are expected in the colon with laxative abuse?
- Mucosal staining due to accumulation of melanin
- Mucosal staining due to accumulation of lipofuscin
- Mucosal sloughing
- Intimal hypertrophy