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Large intestine

Image : “Large intestine” by
bodymybody. License: Public Domain

Location of the Large Intestine

The large intestine originates at the ileocecal valve, the valve that protects the small intestine against bacterial reflux. The adjacent cecum in the right lower abdomen is a blind pouch (cecum means ‘blind gut’). The vermiform appendix is attached to the cecum as an appendage. It is usually located retrocecally, but its location may be variable. The ascending colon is continuous with the cecum and travels upward to the chest.

The large intestine

Image Anatomy of the colon. By Bruce Blaus. License: CC BY 3.0.

At approximately the level of the ninth rib, a curvature of the colon bends abruptly inward to the left, forming the hepatic flexure (flexura coli dextra). The transverse colon extends above the loops of the small intestine and ends in the splenic flexure (flexura coli sinistrain the left half of the body, and it continues as the descending colon to the left anterior iliac spine. The S-shaped sigmoid flexure and, subsequently, the rectum form the distal end of the large intestine.

The large intestene includes the cecum, colon and rectum

Image The large intestine includes the cecum, colon, and rectum. By Phil Schatz. License: (CC BY 4.0).

Outer Appearance of the Large Intestine

The large intestine is approximately 1.5 m long and measures about 5–8 cm in diameter. It runs around segments of the small intestine like a framework.

One of the most important macroscopic features of the large intestine are haustra, which are sacculations, or pouches, in the wall of the large intestine. Haustra located in the internal wall of the intestinal lumen are known as plicae semilunares coli. The teniae are bands of longitudinal muscles, each measuring about 1 cm in width. The tenia libera, which is freely visible can be distinguished from the tenia omentalis, which lies close to the omentum majus and the tenia mesocolica. The large intestine is also characterized by appendices epiploicae, appendages filled with adipose and connective tissue and located at the teniae.

outer shape of the colon

Image: Anatomy of the large intestine. By Phil Schatz. License: CC BY 4.0.

Segments of the large intestine at a glance

  • Cecum (blind gut) with the vermiform appendix
  • Hindgut
    • Colon: colon ascendens, colon transversum, colon descendens, colon sigmoideum
    • Rectum

Large Intestine in Relation to the Peritoneum

The relation of the large intestine to the peritoneum is an important topic for examinations. Its complexity is rooted in embryonic development and the intestinal rotation that occurs during that time. In general, the sections of the large intestine alternate between intraperitoneal and retroperitoneal locations. Thus, the cecum along with the vermiform appendix is located intraperitoneally. Blood vessels of the appendix pass through the mesoappendix, which leads to the cecum and the ileum.

Ascending and descending sections of the colon are located retroperitoneally. The colon transversum and the colon sigmoideum are, in turn, located intraperitoneally. The ligamentum gastrocolicum connects the curvature major of the stomach and the colon transversum. The surgical approach to the pancreas and other retroperitoneal organs requires resection of this ligament to locate the bursa omentalis underneath.

The Large Intestine in Relation to Adjacent Organs

Colonic relations to neighboring organs

Image: The three regions of the small intestine are the duodenum, jejunum, and ileum. By Phil Schatz. License: CC BY 4.0.

  • The colon ascendens extends from the right lower abdomen to the chest. The small intestine is usually located on its left side.
  • The flexura coli dextra borders on the liver and partially touches the right kidney.
  • The colon transversum touches both the liver and the gallbladder.
  • The flexura coli sinistra is slightly higher than the flexura coli dextra; it lies at approximately the level of the tenth rib, bordering the spleen and touching the left kidney.
  • The jejunum is often located on the right side of the colon descendens.

Vasculature of the Large Intestine

The large intestine is supplied by the colic branches of the superior mesenteric artery, namely the Arteria (A.) ileocolicathe A. colica dextra, and the A. colica media. The arterial blood supply changes at the flexura coli sinistra. The blood supply as well as the innervation change at Cannon’s point, the pelvic splanchnic nerves at segments S2–S4. The remaining parts are supplied by the A. colica sinistra, two to three A. sigmoideae, and the A. rectalis superiorthese are the main branches of the inferior mesenteric artery.

Nerve Supply of the Large Intestine

The movement of the large intestine is facilitated by its plexuses in the intestinal wall. Sympathetic fibers reduce intestinal motility, whereas parasympathetic fibers increase it. They originate in the nervus vagus and run to the flexura coli sinistra. At this point, the parasympathetic innervation is derived from Cannon’s point.

Differences between the Large and Small Intestines at a Glance

Macroscopically, the large intestine can be distinguished from the small intestine by its haustra, teniae, and appendices epiploicaeAlso, at the microscopic level, the wall of the large intestine differs significantly from that of the small intestine. The large intestine carries no villi, but rather it holds deep crypts (0.4–0.6 mm in length) containing multiple goblet cells.

Noduli lymphoidei solitarii occasionally exist in the wall of the intestines. Most of the digestion and absorption of nutrients occurs in the small intestine. By contrast, the large intestine is predominantly the site of water extraction. Simultaneously, goblet cells secrete mucus, which serves as a lubricant for stool.

Functions of the Large Intestine

The vermiform appendix is rich in lymphatic tissue and is part of the immune system.

Feces pass the colon in 12–48 hours via slow peristaltic movements and segmentation. Water is absorbed, which results in thickening of the stool. Every day, 0.5 to 2 L of fluid is absorbed. The capacity of large intestine to reabsorb 5 to 6 L of water suggests potential mechanisms to compensate for missing uptake in the small intestine.

Goblet cells that are located in deep crypts secrete mucins. The resulting mucus facilitates the passage of stool through the intestines. The epithelial cells lining the crypt secrete and reabsorb electrolytes. The epithelial sodium channel (ENaC) regulates sodium reabsorption from the stool. This process is controlled by the steroid hormone aldosterone. However, the potassium may be reabsorbed under conditions of deficiency.

The acidic pH in the large intestine ranges between 5.5 and 6.8, with the pH increasing toward the more distal segments.

In the rectum, the stool is stored and is excreted only after the accumulation of large amounts. Otherwise, the stool would be excreted continuously.

histology of the small intestine

Image: (a) The histologies of the large intestine and small intestine (not shown) are adapted for the digestive functions of each organ. (b) This micrograph shows the colon’s simple columnar epithelium and goblet cells; the inset is magnified ×464. (Micrograph provided by the Regents of the University of Michigan Medical School © 2012.) (c) Xxxxx xxxxx xxxxx. (d) Xxxxx xxxxx xxxxx. By Phil Schatz. License: CC BY 4.0.

Intestinal Flora

Another unique feature of the large intestine is the variety of colonizing bacteria. The presence of approximately 100 trillion mainly anaerobic bacteria ensures for the appropriate digestion of otherwise indigestible food components. Furthermore, the intestinal bacteria secrete compounds that are essential for humans, such as vitamin K.

The sensitive intestinal flora may be disrupted as a result of repeated antibiotic therapies, which, in turn, may cause diarrheal disorders.

Pathology of the Large Intestine

Appendicitis in the large intestine

Over the course of a lifetime, approximately 10% of the population suffers from appendicitis. The inflammation is generally caused by an obstruction of the lumen due to calcified feces, tumors, or foreign bodies.

Acute appendicitis may manifest within hours. Initially, pain typically arises in the umbilical area and later in the right lower abdomenIn addition to pain, clinical manifestations include nausea, vomiting, and fever.

McBurney’s point 

McBurney’s point exists in the right abdomen at a distance of one-third on the connecting line between the right spina iliaca anterior superior and the umbilicus. Pressure applied to this area may trigger pain in patients with appendicitis.

Perforation into the peritoneal cavity is a potential complication associated with untreated appendicitis. The subsequent peritonitis can be a life-threatening complication. Generally, appendectomy is indicated for appendicitis.

Irritable bowel syndrome

Irritable bowel syndrome is a group of intestinal diseases with unclear etiology and absence of organic findings. The symptoms include pain, diarrhea, or constipation. Gluten sensitivity and psychologic factors are associated with irritable bowel syndrome.

Diverticulosis of the colon

An intestinal diverticulum is a sac-like bulge of the intestinal wall or even of the intestinal mucosaDiverticulosis is a civilization disorder (a disorder that could be considered to be a production of civilization) that is associated with a diet low in fiber that results in a slow intestinal peristalsis. Forceful contraction of the large intestine increases the pressure on the walls of the colon, resulting in protuberances, usually in the sigmoideum of the colon. Diverticulosis rarely occurs before the age of 30, but the probability after the age of 30 increases by 6–8% annually. Because of the lack of symptoms, this disorder is often detected only incidentally. Possible complications may include diverticulitis, bleeding, perforation, fistula, and stenoses.

Intestinal inflammation

Inflammation in the large intestine is called ‘colitis.’ Intestinal inflammation includes acute and chronic inflammatory bowel diseases.

Acute intestinal inflammation is also called ‘enteritis.’ Colitis ulcerosa is one of the chronic inflammatory diseases characterized by recurrent inflammation of the intestinal tract over decades. This disorder is limited to the colon and rectum.

Polyps in the colon

A polyp is an accumulation of tissue in the large intestine, either wide and flat, branched, or polypoid. They are usually smaller than 1 cm and usually do not cause any symptoms. Possible symptoms, however, are constipation, pain, or blood in the stool. Especially larger polyps may become malignant tumors or colorectal carcinomas (adenoma–carcinoma sequence).

Intestinal cancer

A malignant tumor of the colon is known as ‘colon carcinoma,’ which most often develops via stepwise progression starting with benign polyps and evolving sequentially as adenoma and then carcinoma. Intestinal cancer most frequently occurs in the age group of 60 to 70 years.

A possibly undiagnosed chronic inflammatory bowel disease may exist in younger patients.

Risk factors include advanced age, intestinal polyposis, genetic factors, and colitis ulcerosa. Diet plays a particularly important role. A diet rich in fats increases the risk of cancer, which is reduced by a high-fiber dietary intake. Therefore, intestinal cancer is more common in industrialized countries.

Symptoms such as occult bleeding typically develop late. The prognosis usually depends on the stage of cancer based on the tumor–node–metastasis (TNM) classification. Lymphogenic metastasis occurs early, spreading to the regional lymphatic nodes. Hematogenously, the colon carcinoma metastasizes predominantly to the liver, lungs, and skeleton.

Colon resection

Colon resection entails partial removal of the colonIndications include diverticulosis, polyps of the colon, colon carcinoma, or chronic inflammatory bowel diseases such as colitis ulcerosa.

Examination of the colon

Percussion You may hear a tympanic resonance.
X-ray Contrast enema of the colon
Colonoscopy Performed with a flexible endoscope. Prior to the procedure, the patient receives laxatives and a salt solution in order to cleanse the intestine.
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