Hypothalamus is an almond-sized structure located below the thalamus. Anatomically, it is divided into three regions, each consisting of a numerous nuclei. Hypothalamus plays a major role in the homeostasis of the body. The different regions and their respective nuclei along with their functions are as outlined below.
Anterior region of hypothalamus
The pre-optic area consists of four nuclei namely median pre-optic nucleus, medial pre-optic nucleus, ventrolateral pre-optic nucleus and pre-optic periventricular nucleus. This area of the hypothalamus is responsible for thermoregulation and receives sensory signals from the thermo receptors. It is also thought to influence parenting and sexual behavior and release of gonadotropic hormones. It shows sexual dimorphism.
The medial area comprises of the following nuclei:
- The supra-optic nucleus releases vasopressin and oxytocin.
- The paraventricular nucleus causes release of thyrotropin releasing hormone, corticotropin releasing hormone and somatostatin hormone.
- The anterior hypothalamic nucleus inhibits thyrotropin. It also plays a role in thermoregulation and controls sweating and panting reactions.
- The suprachiasmatic nucleus is responsible for the circadian rhythms.
The lateral area consists of orexinergic nucleus. The orexin neurons control the feeding behavior as well as the arousal reaction. It also controls visceral functions such as respiration, micturition, blood pressure, in collaboration with other structures of the brain.
Tuberal region of hypothalamus
The tuberal region may be divided into the medial and lateral area. The medial area comprises of the following three nuclei:
- The dorsomedial hypothalamic nucleus, which controls the blood pressure, heart rate and gastrointestinal motility.
- The ventromedial nucleus controls satiety.
- The arcuate nucleus releases growth hormone releasing hormone (GHRH). It also controls feeding mechanism and causes prolactin inhibition via dopamine secretion.
The lateral area of the tuberal region performs similar functions as the lateral area of the anterior region.
Posterior region of hypothalamus
It is also divided into medial and lateral area. The medial area consists of:
- The mammillary nuclei, which control the memory.
- The posterior nucleus, which increases blood pressure, causes pupillary dilatation and shivering.
The lateral area comprises of the tuberomamillary nucleus, which controls learning, memory, sleep, arousal, feeding and energy balance.
Brain stem is the posterior part of the brain which connects the superior brain structures above to the spinal cord below. It consists of midbrain, pons and medulla oblongata. The figure shows the components of the brain stem.
The midbrain is divided into three parts: tectum, tegmentum and ventral tegmentum. Tectum is responsible for auditory and visual reflexes. Tegmentum controls the voluntary movements of the body and is the site of origin of cranial nerve III and IV nuclei. The ventral tegmental area is responsible for reward, cognition and motivation. Several psychiatric disorders occur due to malfunctioning of this area of the midbrain.
Pons connects the midbrain to the medulla oblongata. It lies in front of the cerebellum. The nuclei of cranial nerves V-VIII originate from the pons.
Pons has its physiological role in hearing and equilibrium, taste, sensory sensation over the face, secretion of saliva and tear production, eye movements, chewing, facial expressions.
It carries motor signals from the cerebrum to the medulla oblongata and cerebellum and also the sensory signals to the thalamus. The figure beside illustrates the site of origin of the cranial nerves.
The medulla oblongata is the lowermost part of the brain stem, which is in connection with the spinal cord. It consists of the cardiovascular center, which controls the sympathetic and parasympathetic stimulation of the blood vessels and the heart.
The control of ventilation through chemoreceptors maintains an adequate level of oxygen and carbon dioxide in the blood. The vasomotor center controls the blood pressure through sensory signals from the baroreceptor. The vomiting, sneezing, coughing and swallowing reflexes are controlled by it.
Circumventricular Organs (CVOs)
The circumventricular organs are the structures of the brain characterized by an extensive vasculature and lack of blood–brain barrier (BBB). This allows the exchange of substances between the central nervous system (CNS) and the peripheral circulation. The CVOs are broadly classified into two categories: the sensory organs and the secretory organs.
The sensory organs have the ability to detect the plasma composition. They send the sensed information to higher brain centers for the appropriate response. There are four sensory organs in this category:
- Area postrema senses the presence of noxious stimulus and triggers vomiting.
- Vascular organ of the lamina terminalis senses the tonocity of the plasma and helps in the maintenance of body fluid homeostasis.
- Subfornical organ has a role in the maintenance of blood pressure and the energy balance of the body.
These organs respond by feedback mechanism and secrete various hormones and other molecules directly into peripheral blood circulation.
- The subcommissural organ (SCO) helps in maintaining the patency of sylvian duct by secretion of SCO-spondin. It is also hypothesized that it regulates the secretion of aldosterone, detoxification of cerebrospinal fluid (CSF) and osmoregulation.
- Posterior pituitary stores oxytocin and anti-diuretic hormone (ADH) synthesized by the hypothalamus. It plays a role in homeostasis.
- Median eminence is classified as circumventricular organ, though this is still controversial. Due to a rich network of capillaries it allows the transport of neurohormones between CSF and the peripheral blood.
- Pineal gland shows circadian rhythm in its activity. It secretes melatonin under the command of supra-chiasmatic nuclei (SCN). The secretion of melatonin is suppressed in light. Pineal gland is also thought to play a role in sexual development as melatonin has been found in the pre-ovulatory follicles, semen, breast milk and amniotic fluid.
Cerebrospinal Fluid (CSF)
Cerebrospinal fluid is a clear, colorless liquid that flows in the brain and the spinal cord. It is produced by the choroid plexus in the brain and flows in:
- Subarachnoid space between the arachnoid and pia mater
- Ventricular system
- Spinal cord.
Composition of CSF
The pH of CSF is around 7.33 with osmolarity of 295 mOsm/l. It is mainly composed of:
- Water (99%)
- Protein (35 mg/dl)
- Glucose (60 mg/dl)
- Sodium (138 meq/l)
- Potassium (2.8 meq/l)
- Calcium (2.1 meq/l)
- Magnesium (0.3 meq/l)
- Chloride (119 meq/l).
Functions of CSF
- When the brain is suspended in CSF, its mass is changed from 1,400 g to 25 g. This is the neutral buoyancy, which allows the brain to perform its functions without compressing the lower parts. The blood supply to different areas of the brain is not affected by the light weight of the brain.
- It protects the structure of the brain from coming in direct contact with the skull. However, in severe head injuries, the CSF moves to the opposite site of impaction causing brain damage which may lead to death.
- The CSF is drained into peripheral vasculature. This prevents the accumulation of harmful substances around the brain.
- The CSF fluid may decrease in volume in certain areas of the brain to relieve the pressure effects thereby improving the blood supply to that part of the brain.
Clinical correlation of CSF
CSF analysis is the investigative technique performed to know the constituents of CSF. It may be different in many clinical conditions and therefore helps in making the right clinical diagnosis. The procedure performed to obtain CSF is known as the lumbar puncture.
The abnormal accumulation of extra CSF in the ventricles of the brain is called hydrocephalus. It leads to increased intracranial pressure. If this occurs during the mental development of the fetus it leads to an enlarged cranium and the condition is termed as congenital hydrocephalus. It results in mental disability and convulsions and therefore needs prompt intervention. If left untreated it can be fatal.
Baricity is the density of a certain drug compared to the density of the cerebrospinal fluid. It is of particular importance in anesthesiology where the duration of anesthesia depends upon the rate of spread of a certain drug in the intrathecal space. The figure above shows the distribution of CSF in the brain areas.