The heart – a muscle working without exhaustion and breaks. It ensures the blood’s transport through the circulatory system. However, the conditions under which the heart is working do not always stay the same. An aortic stenosis or increased blood reflow via the veins strain the heart. In machines, the settings and scalings would have to be changed. Our organism, however, has it’s own ways of dealing with that. One of them is the so called Frank-Starling mechanism.

Are you more of a visual learner? Check out our online video lectures and start your physiology course now for free!

factors affecting venous return

Image: “Factors affecting venous return.” by Huckfinne – Own work. License: Public Domain

What is the Frank-Starling Mechanism?

The Frank-Starling mechanism is a regulatory mechanism of the heart. It gets activated when the heart needs to pump an increased blood volume that got into the right ventricle. That way, the continuity law is maintained.

If the right ventricle would pump more blood than the left ventricle, a congestion in the pulmonary circulation would be the consequence. The lung´s vessels would have to take up more and more blood, causing an pulmonary edema. Vice versa, edemas in extremities would appear if the right ventricle could not sustain its performance in relation to the left ventricle. Hence, a balance is important to maintain circulation.

Work Diagram of the Heart

Before clarifying how the mechanism works, a normal heart action without any load is shown in a volume-pressure-diagram first (see work diagram of the heart):

Point A marks the volume and the pressure at the end-diastolic volume load. In the isovolumic contraction phase, thy myocardium contracts and the pressure rises while the volume remains constant. At the end of this phase, point B is reached.

During systole, the blood is ejected. The volume decreases while the pressure keeps rising until point C.


The myocardium relaxes and the pressure decreases. The volume, however, remains constant until blood flows from the atrium into the ventricle through the atrio-ventricular valve.

The end-diastolic state is marked with point D. It is shown that the ventricle never empties completely and a residual volume remains.

After connecting points A-D, the resulting area A1 approximately indicates the work provided by the heart. Area A2 shows the diastolic work. The change in volume form point B to C is equivalent to the stroke volume.

Following curves, acquired through experimental studies, can be inserted into the work diagram:

  • Resting tension curve (grey): This curve is obtained after filling the heart with a certain amount of liquids and measuring the resulting volume. With increased volume, myocardial extensibility decreases and the pressure rises rapidly.
  • Isovolumic peak curve (green): While the volume does not change, the pressure rises to a maximum due to contraction of the heart.
  • Isotonic peak curve (yellow): At a certain constant pressure, the stroke volume is is determined by using a point on the resting tension curve.
  • Afterloaded peak curve U (red): For every point on the resting tension curve, there is an afterloaded peak curve. It is obtained by drawing a vertical line until it crosses the isovolumic peak curve and a horizontal line until it crosses the isotonic peak curve. The resulting intersection points are connected to show the afterloaded peak curve. Point C is always on that curve.

Adapdation of heart activity is necessary in change of preload and afterload.

The preload is the volume load at the end-diastolic phase. (point A). An increased preload is equivalent to a higher volume strain. In diastole, the ventricle is filled with more blood.

The afterload is the resistance, against which the blood has to be ejected during systole. It is equivalent to the pressure inside the Aorta. An increased afterload results in a higher pressure burden for the heart – it hast to pump against a higher resistance.

The Frank-Starling Mechanism in Change of Preload

No matter what, the heart has to do more work in increased volume or pressure strain to maintain a balance between blood inflow and blood ejection. The easiest way to learn that is to draw a work diagram by yourself by following these instructions:

The end-diastolic volume is increased:

  • Point A is pushed further to the right on the resting tension curve (A’).
  • Pressure remains constant: Point B changes its position only on a horizontal line (by the same amount as A; B‘).
  • According to a different starting point on the resting tension curve, a different afterloaded peak curve U 2 Point C and D are also shifted (C‘, D‘).
  • The resulting work area A3 is bigger than under normal circumstances, the raised stroke volume is also measurable (SV1 < SV2)

If more blood flows into the right ventricle in diastole, the myocardium is pre-stretched more. This enables a higher tension growth to raise stroke volumes.

The Frank-Starling Mechanism in Change of Afterload

Raised aortic pressure demands more work done by the left ventricle. Otherwise, the stroke volume could not be maintained constant.

  • Point A does not change its position, the ventricle is filled with the same amount of blood.
  • However, point B is now on a higher position on the pressure axis (increased aortic pressure, B’’)
  • Point C is shifted towards the top part (C’’) of the same afterloaded peak curve (point A remains on the same position on the resting tension curve), the afterloaded peak curve is reached earlier. Initially, the stroke volume is decreased.
  • A higher end-systolic volume is obtained: D is shifted towards right, too (D‘‘)
  • During the next stroke, the same amount of blood flows into the ventricle, causing a raised end-diastolic volume.
  • This state corresponds to an increased preload.

The pressure strain is transformed into a volume strain.

Do you want to learn even more?
Start now with 500+ free video lectures
given by award-winning educators!
Yes, let's get started!
No, thanks!

Leave a Reply

Your email address will not be published. Required fields are marked *