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Tonsillitis

Image: “Tonsillitis” by Michaelbladon. License: Public Domain


Function and Location of the Tonsils

 

Throat Anatomy

Image: Tonsils and throat. By Bruce Blaus. License: CC BY 3.0.

The oral cavity is an important area for the processes involved in digestion. It contains the tonsils, which participate in defense of the body. They are located in the upper pharynx and are also commonly known as ‘almonds.’

In total, six tonsils comprise the pharyngeal lymphoid ring (Waldeyer’s tonsillar ring): the paired palatine tonsils (the tonsils located between the palatoglossal and palatopharyngeal arches), the tubal tonsil (the eustachian tonsil, associated with the pharyngeal opening of the auditory tube), the unpaired lingual tonsils (the lingual tonsils, located on the floor of the oropharyngeal passageway, at the root of the tongue), and the pharyngeal tonsils (the adenoid tonsils, located in the roof and the posterior wall of the nasopharynx, also called ‘polyps’).

Located at the entrance to the epipharynx and mesopharynx, the task of the tonsils is to act as filters for ingested or inhaled antigens and to render them harmless.

Histology of the tonsils

The tonsils are accumulations of lymphoid tissue, located just beneath the mucosal epithelial lining of the respiratory and digestive systems. Accordingly, they form part of the mucosa-associated lymphoid tissue (MALT) and are called ‘lymphoepithelial organs.’

The lymphoid tissue is located just beneath the epithelium; this ensures direct contact of lymphocytes with epithelial cells and facilitates protection against pathogens that may enter the body via the mucosa.

When using a compound microscope to study tonsil histology, a characteristic tonsillar surface structure is visible. The epithelium is characterized by invaginations, forming deep tonsillar crypts that markedly increase the surface area and thus enhance antigen uptake.

Note: MALT is a diffuse system of small concentrations of lymphoid tissue that is strategically positioned along with the epithelial mucosal linings. It consists of a T zone, which is located between B cell follicles and a reticular fiber network. In addition to the tonsils, examples of MALT are Peyer’s patches (aggregate nodules associated with the gut) and lymphoid nodules in the vermiform appendix.

The palatine tonsils and the lingual tonsil are covered by stratified squamous nonkeratinized epithelium. The palatine tonsils are located in the isthmus of the fauces, between the palatoglossal arch and the palatopharyngeal arch of the soft palate. This area is called the tonsillar fossa. The lingual tonsil is located in the lamina propria on the dorsal surface of the root of the tongue.

Approximately 20 tonsillar crypts extend through and almost reach the base of the tonsil. Excretory ducts of the mucous glands open into the bases of the tonsillar crypts. The lymphatic epithelium is diffuse and forms an open meshwork of cells interspersed with free cells (dendritic cells, lymphocytes).

The basal lamina is often disrupted, which facilitates infiltration of the epithelium by lymphocytes and macrophages and the migration of antigens to the underlying secondary lymphoid follicles (B zone). Their cap-shaped surface points toward the surface and the oral cavity. It has remained unclear how antigens enter healthy tonsils with stratified squamous epithelium.

Tonsillar invagination crypts often contain oral detritus composed of degenerating cells and deposited material. The crypts of the lingual tonsil are less deep than those of the palatine tonsil.

Pharyngeal tonsils are located in the upper posterior part of the throat, more specifically in the mucosa of the posterior wall of the nasopharynx. Their surface consists of irregular folds, and they are covered by respiratory epithelium. These tonsils are most active in schoolchildren, but this changes with increasing age. In adults, they are usually atrophic.

Diagram of the palatine tonsils

Image: Diagram of the palatine tonsils. By United States National Cancer Institute. License: Public domain.

Tubal tonsils are an accumulation of lymphoid follicles located close to the torus tubarius, posterior to where the auditory tubes open into the throat (pharyngeal opening of the auditory tube—the pharyngeal ostium).

Although all tonsils belong to the lymphatic system, they are not directly located along the routes of afferent and efferent lymphatic vessels in the body. It is important to note that tonsils have no afferent and only small efferent lymphatic vessels, which pass through the submandibular lymph nodes and drain into the superior deep cervical lymph nodes.

Tonsillar hyperplasia and tonsillitis

Tonsils and Adenoids

Image: Tonsils and adenoids. By Bruce Blaus. License: CC BY 3.0.

When tonsils are inflamed (tonsillitis), submandibular lymph nodes are palpable and sensitive to pressure. Because of their location at the back of the mouth, where they guard the entrance to the digestive and respiratory systems, many germs and food components come into contact with the tonsils.

Physiologically, tonsils are rendered harmless, but often contact with viral (in up to 60% of cases) and bacterial (in up to 15–30%) pathogens with the lymphoid tissue induces humoral and cell-mediated immune responses. This leads to inflammation accompanied by symptoms such as fever, odynophagia, swelling and redness of the tonsils, and discharge of yellow or white pus from the tonsillar crypts.

Tonsillitis

Image: Tonsillitis. By Michael Bladon. License: Public domain.

Among children younger than 3 years, the most common pathogens are viruses (adenovirus, Epstein–Barr virus, coxsackievirus, rhinovirus, coronavirus, and influenza virus). Among children older than 5 years and adults, the most frequent germs are bacteria, especially group A beta-hemolytic Streptococcus (Streptococcus pyogenes, or SBHGA) (in almost 40% of all cases).

The exposure of the immune system to pathogens, particularly in children, leads to enlargement of the tonsils (tonsillar hyperplasia or adenoids); this occurs as part of the inflammatory response. Hypertrophic tonsils are tightly packed with enlarged secondary follicles, which indicate that the immune system is ‘ready for battle.’

Swollen adenoids (adenoids are also called ‘polyps’) can cause nasal obstruction (alveolar hypoventilation) and hearing impairment, especially among children; this is caused by a lack of ventilation of the tympanic cavity via the eustachian tube. If left untreated, this obstruction may cause serious delays in speech or language development.

Treatment of tonsillar hyperplasia is based on the severity of the clinical symptoms. It may involve partial (tonsillotomy, TT) or complete (tonsillectomy (TE)) removal of the tonsils.

Treatment usually consists of antibiotic administration (penicillin or macrolides) for bacterial infections, but in some cases, surgery is indicated.

Indications for tonsillectomy are chronically inflamed tonsils with focal infection (spread of pathogens from the foci of infection); prevention of recurrent or persistent ear, nose, and throat (ENT) infections (sinusitis, etc.); abnormal craniofacial (tooth) development due to chronic airway obstruction; articulation errors; pathologic daytime sleepiness; and severe dysphagia.

According to scientific studies, in 70% of all cases, chronic tonsillitis is the main indication for a TE, followed by tonsillar hyperplasia (10.9%), peritonsillar abscess (10.9%) and other indications, e.g., cancer. Tonsilloadenoidectomy is most frequently performed in children around the age of 5.

Interesting facts about suitability for surgery and the surgical procedures of tonsillectomy and tonsillotomy

A tonsillectomy is performed under general anesthetic and takes about 20 minutes.

Surgery should be performed only when the child, adolescent, or adult is physically healthy and had no fever or cold for at least 1 week prior to surgery.

The surgical procedure in children under 1 year remains controversial, as the immune system of these children is still maturing. A decrease in certain blood cells of the immune system (agranulocytes) or cancer of the white blood cells (WBCs) (leukemia) constitute contraindications to surgery.

Before surgery, a conversation with the anesthetist and consultant takes place. If a patient is at high risk for undergoing general anesthesia, surgery is not recommended. Patients on regular medication, e.g., anticoagulants, have to discontinue their medication in consultation with the doctor before surgery. Vaccines should not be administered within about 2 weeks before surgery.

TT is frequently performed in children between 3 and 6 years of age. During this procedure, the tonsils are partially removed. A strong indication for this procedure is tonsillar hyperplasia associated with severe airway obstruction or dysphagia.

Most importantly, the main indication for a TT rather than a TE is tonsillar hyperplasia that is not a sign or consequence of acute or chronic recurrent tonsillitis. During TT, part of the tonsil is removed on an outpatient basis using a laser or by radiofrequency. Thus, the tonsil continues to be lymphatically and immunologically active, which is particularly relevant for children.

Lymphangioma

Image: Lymphangioma. By openI. License: CC BY-SA 2.5.

TE is a procedure during which the tonsils are completely removed and the scar is coagulated. The less heat is produced during surgery, the better it is for the wound and the less damage occurs in the surrounding tissue.

The following methods differ in the degree of heat applied. First, the tonsil is grasped by tonsil-holding forceps and an incision is made in the mucous membrane using a surgical scalpel. In addition to the tonsil, often parts of the palatal arch are also removed from the tonsillar fossa. The following TE techniques and instruments can be used:

  1. Periosteal elevator (raspatory) or rugine
  2. Harmonic scalpel method; tissue is removed via ultrasound and subsequent obliteration.
  3. Bipolar radiofrequency dissection; the tonsil is dissected by a highly focused plasma field and the tissue is coagulated.
  4. Carbon dioxide/diode lasers; laser-assisted serial TE (LAST)

    Tonsillectomy

    Image: Lymphangioma. By openI. License: CC BY-SA 2.5.

For the removal of the vascular pedicle, which is adjacent to the lower palatopharyngeal arch, a loop is used. Hemostasis is achieved with bipolar electric tweezers. After a successful surgical procedure an approximately 2-cm wide wound area can be seen between the posterior and anterior palatine arches. In the following days, these will be covered in white scabs (fibrin).

After about a week, the initial scab is repelled and bleeding may occur. Subsequently, the process of scar healing begins.

Complications and risks of surgery

Because of the direct proximity of major blood vessels leading to the brain, the rupture of these vessels during surgery is probably one of the most feared scenarios; but it is also the least likely. The most common post-TE complication is hemorrhage, which can occur during the healing process if the scab from the wound is dislodged too soon because of the consistent physiologic act of swallowing. Therefore, a long healing period is required.

The risk of bleeding from the surgical wounds is highest in the first 24 hours after surgery, which is why a postoperative inpatient observation period is generally recommended. Extensive postoperative hemorrhage may occur, especially after a TE. In these cases, surgery or even a blood transfusion is sometimes needed, which is why a demand for an outpatient surgical procedure should be rejected.

Overall, according to the Austrian tonsil study 2009/2006, which included over 1 million patient records, post-TE hemorrhage required follow-up treatment and care in only 2.7% of cases. In a group of patients who had been treated using TT, the postsurgical risk for bleeding was 2.7%, and only 0.8% of these patients needed a another intervention.

Note:

  1. The pharyngeal tonsil is a lymphatic organ and should therefore not be removed without a strong indication.
  2. Conservative drug treatment includes a 7-day course of penicillin.
  3. The main indications for a TE currently include obstructive tonsillar hyperplasia, recurrent and chronic inflammation, and suspected malignancy.
  4. The main indication for a TT is tonsillar hyperplasia, which is not a sign or consequence of acute or chronic recurrent tonsillitis.
  5. Post-TE hemorrhage immediately after surgery or about a week later, when scabs begin sloughing off from the surgical sites, represent the highest risk of this procedure. The likelihood of bleeding after a TT is much lower.

Pharyngitis

Pharyngitis commonly presents with the abrupt onset of a sore throat, which is caused by inflammation of the pharyngeal mucosa. Additional symptoms may be fever, the general feeling of having the flu, and dysphonia. If the inflammation includes tonsillitis, it may be called pharyngotonsillitis. Pharyngitis is much more common in children than in adults.

What is the cause of pharyngitis?

Pharyngitis may be caused by bacterial or viral infections; however, most frequently it is caused by most common cold viruses (in up to 60% of cases). These include parainfluenza viruses, adenoviruses, rhinoviruses, and coronaviruses. Once the mucosa of the throat is disrupted by a virus infection, the tissue is susceptible to secondary bacterial infections, which may increase inflammation.

The most common bacteria causing oral stomatitis are streptococci belonging to serogroup A (S. pyogenes). The mechanism that causes this disease is very simple and typical for diseases occurring in winter months: mucous membranes get irritated and dry out when exposed to cold and dry air outdoors and heated air indoors, causing compromised host defense mechanisms.

Pharyngitis can also be triggered by chronic mucosal dysfunction caused by physicochemical factors, such as smoking cigarettes and contact with hazardous irritants, as well as by menopause with its hormonal changes. Transmission of the disease occurs via airborne droplets.

Approach to the diagnosis and treatment of pharyngitis

To be able to exclude other conditions and confirm the clinical diagnosis of pharyngitis, the physician should examine the patient’s vaccination records. With regular successful vaccinations against diphtheria, at least this disorder can be excluded during the differential diagnosis.

The identification of the bacterial pathogen involves swabbing the throat (to obtain pharyngeal exudate), and then targeted antibiotic treatment is administered. Causal treatment of pharyngitis is not possible and also not necessary because the disease subsides in most cases within a week if the patient rests sufficiently and follows medical advice.

Squamous Cell Carcinoma of the Floor of the Mouth

Squamous cell carcinoma (SCC) of the floor of the mouth is a malignant disease that develops in the squamous epithelium of the base of the tongue and affects the cells of the oral mucosa. It includes up to 90% of all cases of oral cancer. It is four times more common in women than men, reaching a peak prevalence between 50 and 59 years. The size of the affected tissue area varies, depending on the time of diagnosis.

In advanced stages, even the muscles forming the floor of the oral cavity, and later also the cervical lymph nodes, may be affected. In 8 of 10 cases, affected patients regularly use alcohol and tobacco (smoking cigarettes, chewing tobacco, and using snuff tobacco).

The effect of smoking on this carcinogenic disease is easily explained: carcinogenic components of cigarette smoke accumulate under the tongue in the saliva. There, they have enough time to exert their harmful effect on the cells. In addition, regular, heavy alcohol consumption increases the risk of oral cancer even further. Poor oral hygiene and a diet low in vitamins, particularly a lack of vitamins A and C, can be harmful as well.

On average, men are three times more likely to be affected than women. Cancer of the floor of the mouth accounts for 6% of all cancers and ranks as the sixth most prevalent malignancy worldwide.

In most cases, cancers of the floor of the mouth are associated with a preceding oral precancerous lesion, which means that even before the malignant transformation, stages of precancerous oral epithelial changes are detectable. So-called facultative precancerous lesions rarely lead to cancer, while obligate precancerous lesions have a high probability of turning into early-stage carcinoma.

Oral leukoplakia, a small, predominantly white patch, is the most common facultative precancerous lesion of the oral mucosa and can be easily overlooked, as it can be quite small. Dentists should remain vigilant for signs of potentially malignant disorders and oral cancer while performing routine oral examinations of patients from the age of 50 onward.

Leukoplakia is often localized in the buccal mucosa or the corners of the mouth. Obligate precancerous lesions, e.g., Bowen’s disease, can occur on the oral mucosa or the sides of the tongue. Frequently, at the time of discovery, these lesions have undergone malignant transformation.

Morphology and prognosis of squamous cell carcinoma of the oral floor

Oral cancer

Image: Oral cancer. By openI. License: CC BY-SA 2.5.

Different histopathologic variants of squamous cell carcinoma have been identified. Each of them has a different prognosis: The conventional, ulcerated form is characterized by invasive growth and occurs in 99% of the cases affected by this cancer. Cancers originating in the tissue that lines the lips have a better prognosis as compared with other oral locations, e.g., the root of the tongue.

Cancer of the tongue

Image: Cancer of the tongue. By wellcomeinages.org. License: CC BY 4.0.

The uncommon, verrucous variant of squamous cell carcinoma is an exophytic, clinically slow-growing lesion that has the potential to metastasize only in an advanced stage of the disease. The spread of cancer to other parts of the body is called ‘metastasis.’ Metastasis of squamous cell carcinoma of the oral floor occurs via the lymphatic route to the submandibular and, less commonly, to the submental lymph nodes. Cancer cells are not disseminated via the bloodstream (hematogenous spread). Cancer of the oral mucosa affects both parotid and pharyngeal lymph nodes. The diagnosis is based on the results of a punch or excisional biopsy.

Clinical symptoms and treatment options

The diagnosis of SCC of the oral floor is challenging, because patients in the initial stages of this disease frequently present with only vague symptoms (i.e. painless lesions) and minimal physical findings. However, if cancer of the oral floor is detected in the early stages, patients have a good chance of recovery. Many nonspecific symptoms, such as halitosis or the presence of phonetic speech disorders, may be indicative of early-stage oral floor cancer.

Diagnostic tests to confirm or exclude the diagnosis of oral cancer include computed tomography (CT) or magnetic resonance imaging of the suspected area. At an advanced stage of oral cancer (from T3), organs potentially affected by metastasis of the primary tumor (e.g., the liver or the kidneys) must be examined.

The treatment of oral cancer usually requires a combination of surgery and radiotherapy. To adequately remove a tumor from the floor of the mouth, approximately 1 cm of normal tissue should surround the tumor. Resection of the floor of the mouth is usually the treatment of choice. If the cancer is more advanced, segmental mandibular resection is necessary.

Also, removal of involved lymph nodes in the neck (neck dissection), which can be performed as a prophylactic measure, is a treatment option. Radiation therapy can be used in the treatment of small tumors. If the cancer is very aggressive, a combination of surgical and radiologic therapy is also possible.

Carcinoma of the Tongue

Cancer of the Tongue

Image: Cancer of the tongue. By openI. License: CC BY-Sa 2.5.

How do I recognize carcinoma of the tongue?

Carcinomas of the tongue and the oral floor are equally difficult to diagnose on the basis of clinical signs and symptoms. Early signs of tongue cancer may be a sore throat, dysphagia, excessive salivation, or in an advanced stage, slurred pronunciation and sensation of a foreign body in the neck and throat. White to yellow plaques on the oral mucosa, which cannot be wiped or scraped off, may be indicative of oral cancer. Symptoms of advanced-stage tongue cancer include different degrees of impairment of tongue movement, depending on the location and extent of the tumor.

Cancer of the Tongue

Image: Cancer of the tongue. By openI. License: CC BY-Sa 2.5.

Movement disorders of the tongue occur only in advanced stages of cancer and have different strengths depending on the location and extent of the tumor. A definitive diagnosis can be obtained by taking a biopsy sample or performing CT scanning or magnetic resonance tomography.

Tongue cancer treatment

Lesions are treated surgically when possible. If the cancer is so severe that a large part of the muscles of the tongue has to be removed, surgery may be performed on only a small portion, complemented by radiotherapy. Otherwise, moving the muscles of the tongue and mouth properly to produce speech would no longer be possible.

Chemotherapy is also recommended if cancer has spread. Abstaining from smoking tobacco and excessive alcohol consumption reduces the risk of recurrent cancer of the tongue or, indeed, the risk of contracting carcinogenesis in the first place.

Note: In histopathology the three S’s of smoking—spirits, syphilis, and septic teeth—have been associated with the emergence of squamous cell cancer of the head and neck. In addition to the known causes of oral cancer, such as smoking, alcohol consumption, and poor oral hygiene, risky sexual practices, and associated infections with high-risk types of human papillomavirus have also been linked to oral cancer.

Dentures: a cause for cancer of the tongue?

Determining the cause of tongue cancer in nonsmoking patients is difficult. This type of cancer usually develops most commonly after the fifth decade of life, when many patients have been fitted with bridges, dentures, or crowns. This leads to the assumption that dentures, particularly ill-fitting dentures, may predispose tissues to malignant changes. However, so far a significant relationship between the use of dentures and the incidence of cancer of the tongue has not been established.

Hypopharyngeal cancer

Anatomy of Nose, Pharynx, Mouth & Larynx

Image: Anatomy of nose pharynx mouth larynx. By Phil Schatz. License: CC BY 4.0.

Hypopharyngeal cancer is a term used for tumors characterized by the malignant degeneration of epithelial cells in the lower part of the throat. The most important risk factors include smoking, heavy use of alcohol, poor dental hygiene affecting the composition of saliva, and work-related contact with metal dust. Cancers of the hypopharynx usually are, like cancers of the tongue and the oral floor, squamous cell carcinomas (SCC).

Hypopharyngeal cancer constitutes 12–15% of SCCs of the head and neck and is characterized as being one of the cancers with a bad prognosis, with overall survival of 10–35% at 5 years after diagnosis.

Localization and symptoms

The three most common sites of origin of hypopharyngeal carcinoma include the pyriform sinus, the postcricoid pharynx, and the posterior pharyngeal wall. The most common symptoms include dysphagia (difficulty swallowing), the sensation of a foreign body in the throat, and stabbing pain radiating toward the ear.

If the tumor has spread to the larynx, it will cause symptoms such as hoarseness and hyperventilation due to shortness of breath (dyspnea). Enlarged lymph nodes behind the ear and below the angle of the jaw are palpable.

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