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lung diseases

Range of lung diseases

The Big 4 Lung Diseases

  1. COPD — the most common cause of acute medical admissions
  2. Asthma — the most common chronic respiratory disease
  3. Lung cancer — the most common fatal cancer in the Western world for both men and women
  4. Pneumonia — the most common serious infectious disease

Other common respiratory diseases

Range of Lung Diseases

Diseases of the airways

Upper airway obstruction
Lower airway obstruction
Airway infection
Airway tumors
  • Lung cancer: squamous and small cell
  • Rarer tumors, e.g., carcinoid, metastases
lung diseases-range

Range of lung diseases

Lung parenchyma (alveoli and interstitium)

Interstitial Lung Diseases
Adult respiratory distress syndrome
Parenchymal tumors
  • Lung cancer: adenocarcinoma
  • Pulmonary metastases


Pulmonary emboli (PE)
Pulmonary hypertension
  • Cor pulmonale
  • Chronic PEs
  • Other causes

Range of lung diseases

Pleural diseases

Pleural infection
Pleural malignancy
  • Primary: mesothelioma
  • Secondary: metastases


Diseases of physiology
Iatrogenic lung disease
  • Procedure-related
  • Caused by drugs
  • Associated with radiotherapy

Investigation of Lung Disease

Different Causes of Large Airway Obstruction

Acute upper airway obstruction

Speed of onset Cause Clinical presentation
Sudden Aspiration of foreign body Mucous plug Very acute dyspnea and stridor
Acute Epiglottis/ tonsillar abscess


Smoke inhalation

Deteriorations of subacute/ chronic causes

Acute dyspnea and stridor

Saliva drooling

Fever (infective cause)

Chronic upper airway obstruction

Speed of onset Cause Clinical symptoms and signs
Subacute/ progressive Cancer: lung/ larynx/ thyroid

Benign tracheal tumors

Massive mediastinal nodes

Vocal cord paralysis

Progressive/ positional dyspnea



Stridor (can be intermittent)

Post obstructive bronchiectasis

Dysphagia (esophageal invasion)

Pain (malignant causes)

Chronic/ non-progressive Post-intubation tracheal stenosis

Post-infective, e.g., tuberculosis


Previous upper airway surgery



Large Airway Obstructions: Clues

  1. ‘Squared off’ flow volume loop of tracheal obstruction

    Minimal variability in peak flow/ spirometry

  2. Positional symptoms rather than diurnal
  3. Inspiratory wheeze (Stridor)
  4. Past history of intubation/ tracheal disease
  5. Characteristic flow-volume loop
  6. Fall in PEFR relatively greater than fall in FEV1


  • Visual confirmation
  • Biopsies to confirm the cause (but can bleed…)
  • Treatment as well

Treatment of acute presentation

  1. Sit the patient up
  2. High flow oxygen or heliox (a mixture of oxygen and helium) via a mask
  3. Intravenous high-dose corticosteroids (reduce edema around obstruction)
  4. Nebulized salbutamol and adrenaline
  5. Intravenous fluid replacement
  6. Potentially urgent intubation or tracheostomy or bronchoscopy intervention

Treatment of chronic obstruction

Chronic—relieve the obstruction by

  1. Treat underlying cause if possible
  2. Bronchoscopic interventions e.g.
    • Stents
    • Laser ablation
  3. Surgical interventions
    • Remove cause
    • Tracheostomy
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