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Image: “Drugs” by Brandon Giesbrecht. License: CC BY 2.0

Definition of Anthelmintics

Anthelmintic, or antihelminthic, are the drugs that kill or expel parasites and are used for the treatment of various diseases caused by parasites.

Helminths are categorized as follows:

  • Nematodes or roundworms.
  • Platyhelminthes or flatworms.
  • Trematodes or flukes.
  • Cestodes or tapeworms.

Overview of Helminthiasis

Helminths have a complex life cycle, involving various host species and vectors in different stages of their life cycle. In most of the parasitic infections, a human acts as а host of the parasites.

There are several major causes of helminthiasis:

  • Poor hygiene.
  • Infection occurs due to the consumption of water and food contaminated with human or animal feces or undercooked meat (pork and fish).
  • Some parasites enter the human body through the skin and insect bites (onchocerca volvulus, Wuchereria bancrofti).

Various Types of Helminths

taenia solium scolex

Image: “Taenia Solium Scolex (x400)” by 커뷰 – Own work. License: CC BY-SA 3.0


Taenia saginata, Taenia solium, Hymenolepis nana

The intermediate hosts of the tapeworms (T. saginata and T. solium) are cattle and pigs.

Taenia solium (pork tapeworm) is most commonly found in Asia and Latin America. In the US, it is present in patients migrated from these countries. It causes neurocysticercosis. Its host is the pig and it can be acquired by a human by eating poorly cooked pork. Its eggs are generally ingested by oral-fecal contamination.

Taenia saginata, also called beef tapeworm, does not cause neurocysticercosis. Usually, humans get infected with T. saginata after consumption of undercooked beef. It causes taeniasis in the intestine and it is harmless. It mostly remains asymptomatic.

Echinococcus Species

echinococcus granulosus

Image: “Echinococcus Granulosus.” by Ganímedes – Own work. License: CC BY-SA 4.0

E. granulosus, E. multilocularis, E. vogeli

The intermediate hosts for this infection are sheep and the primary host are dogs. Under certain conditions, humans can function as an intermediate host. As a consequence, the larvae develop into hydatid cysts within the tissues. They cause the hydatid cysts; the most affected part is the liver (two-thirds of the patients).


Schistosoma haematobium, Schistosoma mansoni, Schistosoma japonicum

Flukes of genus Schistosoma cause schistosomiasis. It is also called snail fever. Different types of snails act as hosts of the genus Schistosoma. Complications arise due to immunological reactions towards trapped eggs of Schistosoma parasite in various tissues. Eggs reach skin, brain, muscle, adrenal glands and eyes. Eventually, the excessive inflammatory process causes organ damage.

Tissue roundworms

Trichinella spiralis, Dracunculus medinensis (guinea worm), Wuchereria bancrofti, Loa loa, Onchocerca volvulus, Brugia malayi

wuchereria bancrofti

Image: “Wuchereria bancrofti Microfilaria of Wuchereria bancrofti, from a patient seen in Haiti.” License: Public Domain

The adult filariae of these types of worms reside mainly in the lymphatic system, connective tissues or mesentery of the host and produce live embryos or microfilariae, which travel in the bloodstream through transmission from mosquitoes or similar insects when they feed.

After development within the secondary host, the larvae pass to the mouthparts of the insect and are re-injected into humans.

Common filarial diseases are onchocerciasis (the presence of microfilariae in the eye causing ‘river blindness’), loiasis (the microfilariae causing inflammation in the skin and other tissues), trichinosis (the larvae from the viviparous female in the intestine migrate to the skeletal muscle, where they become encysted).

wuchereria-induced elephantiasis

Image: “An infection in the leg by Wuchereria bancrofti.” by Unknown. License: CC BY-SA 3.0


Ascaris Lumbricoides, Toxocara canis

Ascariasis is the most common intestinal nematode infection. It remains asymptomatic in most of the patients. However, it can cause pulmonary complications (cough, wheezing) and intestinal obstruction when a person is heavily infected. It is usually prevalent in the areas of poor sanitation and hygiene.


Ancylostoma duodenale, Necator americanus

The reason for the infection is larval penetration through the skin. After reaching the lung, the larvae migrate to the oral cavity and are swallowed, the hookworm attaches to the intestinal mucosa and feeds through the host.

Anthelmintic Drugs


The drug has a broad range of activity in neurocysticercosis, echinococcosis, ascariasis, hookworm, and trichuriasis. The drug acts by inhibiting the polymerization of helminth β-tubulin, thus interfering with microtubule-dependent functions such as glucose uptake in the helminths.

Bioavailability of albendazole is less than 5 % when taken on an empty stomach. Absorption of the drug is enhanced by administering it with fatty foods.

Side effects include abdominal pain, nausea, vomiting, and increased hepatic transaminases; these are generally transient and usually do not require discontinuation of the drug. LFT’s should be monitored during therapy with albendazole.


The drug is effective against a spectrum of intestinal and tissue nematode infections, including ascariasis, hookworm, enterobiasis, and trichuriasis. Mebendazole is the preferred drug for the treatment of multiple infestations and is more efficacious than albendazole in trichuriasis.

The site of action of the drug is the microtubular protein β-tubulin of the parasite. It binds to β-tubulin of the worm with high affinity and inhibits its polymerization. It also blocks glucose uptake in the helminths.

Albendazole and mebendazole are effective against the following parasites:

trichinella spiralis in muscle tissue

Image: “Trichinella Spiralis in Muscle Tissue.” by Doc. RNDr. Josef Reischig, CSc. – Author’s archive. License: CC BY-SA 3.0

  • Ascaris lumbricoides
  • Necator americanus
  • Trichinella spiralis
  • Enterobius vermicularis
  • Trichuris trichiura
  • Echinococcus
  • Strongyloides stercoralis
  • Taenia solium
  • Microsporidia


Thiabendazole is an older benzimidazole derivative and, apart from the therapeutic response against various helminths, it has symptomatic relief in cutaneous larva migrans and skeletal muscle symptoms produced by the migration of Trichinella spiralis larvae to muscles.

The mechanism of action of thiabendazole is similar to albendazole. Thiabendazole has anti-inflammatory, analgesic and antipyretic actions. Adverse reactions include dizziness, nausea, vomiting, drowsiness, pruritus, headache, neuropsychiatric disturbances, hepatitis and hypersensitivity reactions including Stevens-Johnson syndrome. A topical suspension of thiabendazole is used for cutaneous larva migrans.

Diethylcarbamazine (DEC)

It is a piperazine derivative that is effective against lymphatic filariasis, loiasis, and visceral larva migrans. Diethylcarbamazine is only effective on the microfilaria (larvae) stage of various parasites. It does not kill the adult parasite (microfilaria).

It may act by changing the parasite such that it becomes susceptible to the host’s normal immune responses (phagocytosis). However, the exact mechanism of action is unclear. It may also interfere with helminth arachidonate metabolism.

It is a drug of choice for loiasis. It is also the drug of choice for filariasis caused by Wuchereria bancrofti and Brugia malayi. Nausea, loss of appetite, headache, weakness, and dizziness are common side effects.


It has activity against schistosomes, cestodes, and their larval forms, but not nematodes. It acts by causing leakage of intracellular calcium from the cell membranes of parasites producing contracture and paralysis. The paralyzed tapeworms are dislodged from the attached intestinal mucosa and are expelled from the intestine. Flukes and schistosomes are also cleared in tissues and veins.

Common side-effects are appetite loss, dizziness, drowsiness, headache, malaise, abdominal pain, nausea, vomiting, and diaphoresis. Undesirable effects are usually transitory and rarely of clinical importance.

It is a drug of choice to treat the cysticercosis caused by T. solium. Side effects are prominent in patients with a heavy parasite load because of products released from the dead worms.

Praziquantel is contraindicated in the treatment of ocular cysticercosis, as the destruction of the organism can cause permanent damage to the eyes. Praziquantel is considered safe for pregnant and lactating women (category B drug).


It is highly active against Ascaris and Enterobius infections with cure rates of 90—100 %. It causes hyperpolarization of worm muscle by opening chloride channels that cause relaxation and depresses responsiveness to the contractile action of ACh. Flaccid paralysis occurs and worms are expelled alive. Piperazine is safe and well tolerated. Nausea, vomiting, abdominal discomfort and urticaria are occasional.

Pyrantel pamoate

It is effective against the following helminths:

  • Ascaris lumbricoides
  • Necator americanus
  • Enterobius vermicularis

It is a depolarizing neuromuscular blocking agent and it causes paralysis in the parasite. It also inhibits the cholinesterase. It is poorly absorbed by the GI tract.

Important: It is most effective against intestinal parasites. Caution should be taken while treating the patient with liver dysfunctions.


It is active against T. saginata, T. solium, Diphyllobothrium latum, and Hymenolepis nana, as well as threadworm. The drug acts by inhibiting oxidative phosphorylation in mitochondria and interfering with the anaerobic generation of ATP in the tapeworm; thus, organisms are killed due to the unavailability of ATP. It does not kill ova/larva.

It is minimally absorbed from the GI tract and no systemic toxicity occurs. It is well tolerated; minor abdominal symptoms are produced occasionally. Malaise, pruritus, and lightheadedness are rare. Niclosamide is safe during pregnancy and in patients with poor health.


Levamisole is effective in common roundworm (A. lumbricoides). It has a nicotine-like action stimulating and blocking the neuromuscular junctions. Consequently, it causes the paralysis of parasites and they are expelled from the body through feces. Low incidences of side effects are nausea, abdominal pain, giddiness, fatigue, drowsiness or insomnia.


It is obtained from Streptomyces avermitilis. Ivermectin acts on the glutamate-gated chloride channels (GluCls) present in the protostome invertebrates. They control the locomotion and feeding in the parasites. Ivermectin causes the hyperpolarization of the GluCls, resulting in the paralysis and death of the parasite.

Important: Ivermectin is only effective on the larvae stage of various parasites. It does not kill the adult parasite.
life cycle of onchocerca volvulus

Image: “The life cycle of O. volvulus.” by Giovanni Maki, derived from a CDC image at – Basáñez M-G, Pion SDS, Churcher TS, Breitling LP, Little MP, et al. (2006) River Blindness: A Success Story under Threat? PLoS Med 3(9): e371. doi:10.1371/journal.pmed.0030371 (image link). License: CC BY 2.5

Ivermectin is active on the following parasites:

  • Onchocerca volvulus
  • Strongyloides stercoralis
  • Ascaris lumbricoides
  • Trichuris trichiura
  • Enterobius vermicularis
  • Filariasis

Onchocerciasis is caused by Onchocerca volvulus – the vector is a black fly (Simulium genus). Humans are the hosts of Onchocerca volvulus. The disease is also called river blindness. It is most common in West African savanna areas and it usually causes blindness by the age of 40—50 years in the affected individuals.

Ivermectin (150 mcg/kg, OD oral route) kills 90 % of the microfilaria within 1 week of treatment. However, the therapy needs to be continued for 10—12 years (throughout the lifespan of the parasite) to kill the parasite. It has a long half-life of 48—60 hours.

Adverse effects are usually the result of the death of the parasites. These include fever, headache, mild-pruritus, giddiness, weakness, rash, nausea, abdominal pain, constipation, lethargy joint/muscle pain, hypotension, tachycardia, and edema. These reactions are mild and last for two days after treatment.

In some patients (1—3 %), the reaction could be severe due to high fever, hypotension, and bronchospasm. Corticosteroids are given in such cases for the management of adverse effects. Ivermectin is contraindicated in pregnant and lactating women.


It is given with triclabendazole to treat the infections (fascioliasis) caused by sheep fluke. Mechanism of action is unknown. Fascioliasis is caused by Fasciola hepatica.

Drug of Choice for the Treatment of Helminthic Infections

Roundworms (Nematodes)

  • Ascaris lumbricoides: (mnemonics: PAM) Pyrantel pamoate, Albendazole, Mebendazole
  • Necator americanus: (PAM) Pyrantel pamoate, Albendazole, Mebendazole
  • Trichuris trichiuria: Albendazole, Mebendazole
  • Strongyloides stercoralis: Ivermectin
  • Enterobius vermicularis: Pyrantel pamoate, Mebendazole
  • Trichinella spiralis: Mebendazole or Albendazole
  • Cutaneous larva migrans: Albendazole, Ivermectin
  • Wucheria bancrofti and Brugia malayi: DEC (Diethylcarbamazine)
  • Onchocerca volvulus: Ivermectin

Flukes (Trematodes)

  • Schistosoma haematobium: Praziquantel
  • Schistosoma mansoni: Praziquantel
  • Schistosoma japonicum: Praziquantel
  • Paragonimus westermani: Praziquantel
  • Fasciola hepatica: Bithionol or Triclalbendazole
  • Fasciolopsis buski: Praziquantel or Niclosamide

Tapeworms (Cestodes)

  • Taenia saginata: Praziquantel or Niclosamide
  • Taenia solium: Praziquantel or Niclosamide
  • Cysticercosis: Albendazole
  • Diphyllobothrium latum: Praziquantel or Niclosamide
  • Echinococcus granulosus: Albendazole
  • Loa loa: DEC
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