Nephrotic Syndrome

Nephrotic Syndrome

by Amy Sussman, MD

Nephrotic syndrome is not a histologic diagnosis; rather, it is the term for a clinical syndrome that encompasses the findings of massive proteinuria leading to hypoalbuminemia, resulting in various complications such as hyperlipidemia and edema. The underlying pathology is thought to be damage to the basement membrane in the renal glomerulus. This glomerular permeability may be due to a primary renal etiology, or it may be secondary to systemic causes or external factors, such as drug use, autoimmune disease, diabetes, or infections.

Often, a clinical history will lead the astute clinician toward a subcategory of nephrotic syndrome. For example, a child with sudden-onset nephrotic syndrome is likely to have minimal change disease, and a steroid trial might be indicated as both a diagnostic and a therapeutic maneuver. However, an HIV-infected patient is more likely to have focal segmental glomerulosclerosis (FSGS), and a biopsy would be needed to confirm the diagnosis.

Course Details

  • Videos 11
  • Duration 0:55 h
  • Quiz questions 30
  • Concept Pages 7


Your Educators of course Nephrotic Syndrome

 Amy Sussman, MD

Amy Sussman, MD

Dr. Amy Sussman is an Associate Professor of Medicine and the Vice Chair of Education in the Department of Medicine of the University of Arizona (UA), USA.
She obtained her MD from the University of Arizona in 2001 and completed residency and a Nephrology Fellowship at the University of Washington. Dr. Sussman was recruited back to the UA in 2009 and also serves as her department's clerkship director, and as the program director of the UA Nephrology Fellowship.
Because of her strong emphasis on medical student teaching, she has been distinguished with multiple teaching awards in the UA College of Medicine.
Within Lecturio, Dr. Sussman teaches courses on Nephrology.

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Nephrotic Syndrome lectures, excellent tool for ABIM renewal prep.
By Lasaundra Watson W. on 22. March 2024 for Nephrotic Syndrome

Dr. Sussman’s lecture style is calm and well paced. She is informative w/o the “drinking from a firehose” effect. Her visuals are perfect for “mind maps”. I’m using this program to prep for ABIM renewal. It’s an excellent tool. I would definitely recommend it to a colleague.

Review of Nephrotic Syndrome lectures
By Rachael K. on 19. October 2022 for Nephrotic Syndrome

Video lectures were quite informative and helpful . The presentation is clear for the intended audience

By Donald L. on 02. May 2022 for Membranous Nephropathy – Nephrotic Syndrome

Thank you. well organized. risk of progression was a good add in.

Terrific presenter, Great information.
By Dr Glenn G. on 25. January 2022 for Nephrotic Syndrome

Dr. Sussman is a premier presenter. She is enthusiastic about her specialty. I feel that she's speaking directly to me rather than lecturing to a camera. The information is critically important and up-to-date for both experienced clinicians and those preparing to pass their boards.