Nephrotic syndrome is not a histologic diagnosis; rather, it is the term for a clinical syndrome that encompasses the findings of massive proteinuria leading to hypoalbuminemia, resulting in various complications such as hyperlipidemia and edema. The underlying pathology is thought to be damage to the basement membrane in the renal glomerulus. This glomerular permeability may be due to a primary renal etiology, or it may be secondary to systemic causes or external factors, such as drug use, autoimmune disease, diabetes, or infections.
Often, a clinical history will lead the astute clinician toward a subcategory of nephrotic syndrome. For example, a child with sudden-onset nephrotic syndrome is likely to have minimal change disease, and a steroid trial might be indicated as both a diagnostic and a therapeutic maneuver. However, an HIV-infected patient is more likely to have focal segmental glomerulosclerosis (FSGS), and a biopsy would be needed to confirm the diagnosis.
Video lectures were quite informative and helpful . The presentation is clear for the intended audience
Thank you. well organized. risk of progression was a good add in.
Dr. Sussman is a premier presenter. She is enthusiastic about her specialty. I feel that she's speaking directly to me rather than lecturing to a camera. The information is critically important and up-to-date for both experienced clinicians and those preparing to pass their boards.
Very clear and structured lecture! I enjoyed the explanation of the subepithelial deposition on the diagram.