Nephrotic syndrome (NS) is a clinical syndrome defined by massive proteinuria responsible for hypoalbuminemia, with resulting hyperlipidemia, edema, and various complications. It is caused by increased permeability through the damaged basement membrane in the renal glomerulus. It results from an abnormality of glomerular permeability that may be primary with a disease specific to the kidneys or secondary to congenital infections, diabetes, systemic lupus erythematosus, neoplasia, or certain drug use.
Often, a clinical history will lead the astute clinician toward a subcategory of nephrotic syndrome. For example, a child with sudden-onset nephrotic syndrome is likely to have minimal change disease, and a steroid trial might be indicated as both a diagnostic and a therapeutic maneuver. However, an HIV-infected patient is more likely to have FSGS, and a biopsy would be needed to confirm the diagnosis.
Video lectures were quite informative and helpful . The presentation is clear for the intended audience
Thank you. well organized. risk of progression was a good add in.
Dr. Sussman is a premier presenter. She is enthusiastic about her specialty. I feel that she's speaking directly to me rather than lecturing to a camera. The information is critically important and up-to-date for both experienced clinicians and those preparing to pass their boards.
Very clear and structured lecture! I enjoyed the explanation of the subepithelial deposition on the diagram.