Intracerebral hemorrhage (ICH) refers to a spontaneous or traumatic bleed into the brainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and Classification parenchyma and is the 2nd-most common cause of cerebrovascular accidents (CVAs), commonly known as stroke, after ischemic CVAs. Trauma, hypertensionHypertensionHypertension, or high blood pressure, is a common disease that manifests as elevated systemic arterial pressures. Hypertension is most often asymptomatic and is found incidentally as part of a routine physical examination or during triage for an unrelated medical encounter. Hypertension, vasculopathy, vascular malformations, tumors, coagulopathy, and hemorrhagic conversion of ischemic strokeIschemic StrokeAn ischemic stroke (also known as cerebrovascular accident) is an acute neurologic injury that occurs as a result of brain ischemia; this condition may be due to cerebral blood vessel occlusion by thrombosis or embolism, or rarely due to systemic hypoperfusion. Ischemic Stroke may all be causative factors. Clinical presentation may vary depending on the size and location of the hemorrhage and may range from headacheHeadacheThe symptom of pain in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of headache disorders.Brain Abscess, neurologic signs and symptoms, and altered level of consciousness to comaComaComa is defined as a deep state of unarousable unresponsiveness, characterized by a score of 3 points on the GCS. A comatose state can be caused by a multitude of conditions, making the precise epidemiology and prognosis of coma difficult to determine. Coma. Treatment includes stabilization, stopping or reversing of anticoagulationAnticoagulationPulmonary Hypertension Drugs, blood pressure control, monitoring in a neurologic ICUICUHospital units providing continuous surveillance and care to acutely ill patients.West Nile Virus, and possible neurosurgical intervention. Intracerebral hemorrhage is associated with significant morbidityMorbidityThe proportion of patients with a particular disease during a given year per given unit of population.Measures of Health Status and mortalityMortalityAll deaths reported in a given population.Measures of Health Status.
Intracerebral hemorrhage (ICH) refers to a spontaneous or traumatic bleed into the brainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and Classification parenchyma and is the 2nd-most common cause of cerebrovascular accidents (CVAs).
Basal gangliaBasal GangliaBasal ganglia are a group of subcortical nuclear agglomerations involved in movement, and are located deep to the cerebral hemispheres. Basal ganglia include the striatum (caudate nucleus and putamen), globus pallidus, substantia nigra, and subthalamic nucleus. Basal Ganglia: Anatomy
Internal capsuleCapsuleAn envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.Bacteroides
BrainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and Classification stem
CerebellumCerebellumThe cerebellum, Latin for “little brain,” is located in the posterior cranial fossa, dorsal to the pons and midbrain, and its principal role is in the coordination of movements. The cerebellum consists of 3 lobes on either side of its 2 hemispheres and is connected in the middle by the vermis. Cerebellum: Anatomy
Lobar ICH:
Accounts for ⅓ of the cases of ICH
Affects structures of the cerebral cortexCerebral cortexThe cerebral cortex is the largest and most developed part of the human brain and CNS. Occupying the upper part of the cranial cavity, the cerebral cortex has 4 lobes and is divided into 2 hemispheres that are joined centrally by the corpus callosum. Cerebral Cortex: Anatomy and the superficial subcortical structures
Involves 1 or more lobes of the brainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and Classification
Epidemiology
Spontaneous (atraumatic) ICH accounts for approximately 10% of CVAs.
IncidenceIncidenceThe number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from prevalence, which refers to all cases in the population at a given time.Measures of Disease Frequency:
Approximately 12–20 per 100,000 individuals
Doubles every 10 years in individuals 35 years and older
In the US, the incidenceIncidenceThe number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from prevalence, which refers to all cases in the population at a given time.Measures of Disease Frequency varies by ethnicity (highest to lowest):
(a) illustration of intracerebral hemorrhage
(b) CT of intracerebral hemorrhage
Image: “1602 The Hemorrhagic Stroke-02” by OpenStax College. License: CC BY 3.0
Etiology
Risk factors
HypertensionHypertensionHypertension, or high blood pressure, is a common disease that manifests as elevated systemic arterial pressures. Hypertension is most often asymptomatic and is found incidentally as part of a routine physical examination or during triage for an unrelated medical encounter. Hypertension:
Most important risk factor
More than doubles the risk for ICH
Vasculopathy
Advanced age
Prior CVA
Coagulopathy:
Anticoagulant therapy
Antiplatelet therapy (minor increase in risk)
ThrombolyticsThrombolyticsThrombolytics, also known as fibrinolytics, include recombinant tissue plasminogen activator (TPa) (i.e., alteplase, reteplase, and tenecteplase), urokinase, and streptokinase. The agents promote the breakdown of a blood clot by converting plasminogen to plasmin, which then degrades fibrin. Thrombolytics
Inherited bleeding disordersBleeding disordersHypocoagulable conditions, also known as bleeding disorders or bleeding diathesis, are a diverse group of diseases that result in abnormal hemostasis. Physiologic hemostasis is dependent on the integrity of endothelial cells, subendothelial matrix, platelets, and coagulation factors. The hypocoagulable states result from abnormalities in one or more of these contributors, resulting in ineffective thrombosis and bleeding.Hypocoagulable Conditions
Chronic liverLiverThe liver is the largest gland in the human body. The liver is found in the superior right quadrant of the abdomen and weighs approximately 1.5 kilograms. Its main functions are detoxification, metabolism, nutrient storage (e.g., iron and vitamins), synthesis of coagulation factors, formation of bile, filtration, and storage of blood. Liver: Anatomy disease
CKDCKDChronic kidney disease (CKD) is kidney impairment that lasts for ≥ 3 months, implying that it is irreversible. Hypertension and diabetes are the most common causes; however, there are a multitude of other etiologies. In the early to moderate stages, CKD is usually asymptomatic and is primarily diagnosed by laboratory abnormalities.Chronic Kidney Disease
History of falls
ObesityObesityObesity is a condition associated with excess body weight, specifically with the deposition of excessive adipose tissue. Obesity is considered a global epidemic. Major influences come from the western diet and sedentary lifestyles, but the exact mechanisms likely include a mixture of genetic and environmental factors. Obesity
Low cholesterolCholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Cholesterol Metabolism levels (especially LDL)
Lifestyle factors:
Sedentary lifestyle
Heavy dependence on alcohol
Tobacco use
Use of stimulant drugs:
CocaineCocaineAn alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.Local Anesthetics
AmphetaminesAmphetaminesAnalogs or derivatives of amphetamine. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.Stimulants
SympathomimeticsSympathomimeticsSympathomimetic drugs, also known as adrenergic agonists, mimic the action of the stimulators (î±, β, or dopamine receptors) of the sympathetic autonomic nervous system. Sympathomimetic drugs are classified based on the type of receptors the drugs act on (some agents act on several receptors but 1 is predominate).Sympathomimetic Drugs
Leading causes
Hypertensive vasculopathy:
Most common cause
Association with deep ICH is greater than that with lobar ICH.
Affected vessels include branches of:
Basilar artery
Posterior cerebral arteriesArteriesArteries are tubular collections of cells that transport oxygenated blood and nutrients from the heart to the tissues of the body. The blood passes through the arteries in order of decreasing luminal diameter, starting in the largest artery (the aorta) and ending in the small arterioles. Arteries are classified into 3 types: large elastic arteries, medium muscular arteries, and small arteries and arterioles. Arteries: Histology
Middle cerebral arteryMiddle cerebral arteryThe largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the cerebral cortex. These are the areas involved in motor, sensory, and speech activities.Cerebrovascular System: Anatomy
Cerebellar arteriesArteriesArteries are tubular collections of cells that transport oxygenated blood and nutrients from the heart to the tissues of the body. The blood passes through the arteries in order of decreasing luminal diameter, starting in the largest artery (the aorta) and ending in the small arterioles. Arteries are classified into 3 types: large elastic arteries, medium muscular arteries, and small arteries and arterioles. Arteries: Histology
Affected vessels largely supply:
PonsPonsThe front part of the hindbrain (rhombencephalon) that lies between the medulla and the midbrain (mesencephalon) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the cerebellum to the cerebrum.Brain Stem: Anatomy
MidbrainMidbrainThe middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the pons and the diencephalon. Midbrain contains two major parts, the dorsal tectum mesencephali and the ventral tegmentum mesencephali, housing components of auditory, visual, and other sensorimotor systems.Brain Stem: Anatomy
ThalamusThalamusThe thalamus is a large, ovoid structure in the dorsal part of the diencephalon that is located between the cerebral cortex and midbrain. It consists of several interconnected nuclei of grey matter separated by the laminae of white matter. The thalamus is the main conductor of information that passes between the cerebral cortex and the periphery, spinal cord, or brain stem.Thalamus: Anatomy
Globus pallidusGlobus pallidusThe representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.Basal Ganglia: Anatomy
Putamen
Caudate nucleusNucleusWithin a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (cell nucleolus). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the endoplasmic reticulum. A cell may contain more than one nucleus.The Cell: Organelles
Cerebellar nucleiCerebellar nucleiFour clusters of neurons located deep within the white matter of the cerebellum, which are the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.Cerebellum: Anatomy
Increased risk in the setting of comorbid vasculitisVasculitisInflammation of any one of the blood vessels, including the arteries; veins; and rest of the vasculature system in the body.Systemic Lupus Erythematosus and/or coagulopathy
Cerebral amyloid angiopathyAmyloid angiopathyA heterogeneous group of sporadic or familial disorders characterized by amyloid deposits in the walls of small and medium sized blood vessels of cerebral cortex and meninges. Clinical features include multiple, small lobar cerebral hemorrhage; cerebral ischemia; and cerebral infarction. Cerebral amyloid angiopathy is unrelated to generalized amyloidosis. Amyloidogenic peptides in this condition are nearly always the same ones found in alzheimer disease.Alzheimer Disease:
2nd-most common cause
Association with lobar ICH is greater than that with deep ICH.
More common in the elderly
Amyloid accumulation in the arteriolesArteriolesThe smallest divisions of the arteries located between the muscular arteries and the capillaries.Arteries: Histology of the cortex is causative.
Affected individuals are prone to recurrent ICH.
Other causes
Vascular malformations:
Arteriovenous malformations
Cavernous malformations
ThrombosisThrombosisFormation and development of a thrombus or blood clot in the blood vessel.Epidemic Typhus of the cerebral vein:
Most common in individuals with thrombophiliaThrombophiliaA disorder of hemostasis in which there is a tendency for the occurrence of thrombosis.Hypercoagulable States
ThrombosisThrombosisFormation and development of a thrombus or blood clot in the blood vessel.Epidemic Typhus increases venous pressure and leads to venous capillary rupture.
Hemorrhagic transformationTransformationChange brought about to an organism’s genetic composition by unidirectional transfer (transfection; transduction, genetic; conjugation, genetic, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell’s genome.Bacteriology of ischemic CVAs:
Common in large ischemic infarcts with significant associated cerebral edemaCerebral edemaIncreased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries. An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive hydrocephalus).Increased Intracranial Pressure (ICP)
Pituitary tumorsPituitary tumorsNeoplasms which arise from or metastasize to the pituitary gland. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties. Pituitary tumors may compress adjacent structures, including the hypothalamus, several cranial nerves, and the optic chiasm. Chiasmal compression may result in bitemporal hemianopsia.Pituitary Adenomas
MeningiomaMeningiomaMeningiomas are slow-growing tumors that arise from the meninges of the brain and spinal cord. The vast majority are benign. These tumors commonly occur in individuals with a history of high doses of skull radiation, head trauma, and neurofibromatosis 2. Meningioma
Acoustic neuromaAcoustic neuromaAcoustic neuroma, also referred to as vestibular schwannoma, is a benign tumor arising from Schwann cells of the vestibular component of the cranial nerve VIII. Acoustic neuroma forms within the internal auditory meatus and extends into the cerebellopontine angle. Acoustic Neuroma
Metastatic tumors:
MelanomaMelanomaMelanoma is a malignant tumor arising from melanocytes, the melanin-producing cells of the epidermis. These tumors are most common in fair-skinned individuals with a history of excessive sun exposure and sunburns. Melanoma
Lung carcinoma
ChoriocarcinomaChoriocarcinomaA malignant metastatic form of trophoblastic tumors. Unlike the hydatidiform mole, choriocarcinoma contains no chorionic villi but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (trophoblasts). It is characterized by the large amounts of chorionic gonadotropin produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin.Gestational Trophoblastic Disease
Renal cell carcinomaRenal cell carcinomaRenal cell carcinoma (RCC) is a tumor that arises from the lining of the renal tubular system within the renal cortex. Renal cell carcinoma is responsible for 80%-85% of all primary renal neoplasms. Most RCCs arise sporadically, but smoking, hypertension, and obesity are linked to its development. Renal Cell Carcinoma
ThyroidThyroidThe thyroid gland is one of the largest endocrine glands in the human body. The thyroid gland is a highly vascular, brownish-red gland located in the visceral compartment of the anterior region of the neck.Thyroid Gland: Anatomy carcinoma
Infection of CNS structures:
MeningitisMeningitisMeningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis
EncephalitisEncephalitisEncephalitis is inflammation of the brain parenchyma caused by an infection, usually viral. Encephalitis may present with mild symptoms such as headache, fever, fatigue, and muscle and joint pain or with severe symptoms such as seizures, altered consciousness, and paralysis.Encephalitis
BrainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and ClassificationabscessAbscessAccumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Chronic Granulomatous Disease
Mycotic aneurysms:
Originate from the emboli from infective endocarditisInfective endocarditisInfective endocarditis (IE) is caused by infection or inflammation of the inner lining of the heart (endocardium), most commonly affecting the heart valves.Endocarditis
May seed and infect the arterial wall causing weakening and aneurysmAneurysmAn aneurysm is a bulging, weakened area of a blood vessel that causes an abnormal widening of its diameter > 1.5 times the size of the native vessel. Aneurysms occur more often in arteries than in veins and are at risk of dissection and rupture, which can be life-threatening. Thoracic Aortic Aneurysms formation
Cerebral vasculitisVasculitisInflammation of any one of the blood vessels, including the arteries; veins; and rest of the vasculature system in the body.Systemic Lupus Erythematosus: from the primary CNS or systemic vasculitisVasculitisInflammation of any one of the blood vessels, including the arteries; veins; and rest of the vasculature system in the body.Systemic Lupus Erythematosus
In the absence of trauma, cerebral parenchymal bleed generally results from the rupture of small penetrating arteriesArteriesArteries are tubular collections of cells that transport oxygenated blood and nutrients from the heart to the tissues of the body. The blood passes through the arteries in order of decreasing luminal diameter, starting in the largest artery (the aorta) and ending in the small arterioles. Arteries are classified into 3 types: large elastic arteries, medium muscular arteries, and small arteries and arterioles. Arteries: Histology.
Vascular rupture
Vascular rupture often occurs at or near the bifurcation of the affected arteriolesArteriolesThe smallest divisions of the arteries located between the muscular arteries and the capillaries.Arteries: Histology and is attributed to degenerative vascular changes associated with:
Common vascular risk factors:
Advancing age
HypertensionHypertensionHypertension, or high blood pressure, is a common disease that manifests as elevated systemic arterial pressures. Hypertension is most often asymptomatic and is found incidentally as part of a routine physical examination or during triage for an unrelated medical encounter. Hypertension
DiabetesDiabetesDiabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and dysfunction of the regulation of glucose metabolism by insulin. Type 1 DM is diagnosed mostly in children and young adults as the result of autoimmune destruction of β cells in the pancreas and the resulting lack of insulin. Type 2 DM has a significant association with obesity and is characterized by insulin resistance.Diabetes Mellitus
SmokingSmokingWillful or deliberate act of inhaling and exhaling smoke from burning substances or agents held by hand.Interstitial Lung Diseases
Hypertensive vasculopathy:
Cumulative effect of aging and vascular shear forces
HyperplasiaHyperplasiaAn increase in the number of cells in a tissue or organ without tumor formation. It differs from hypertrophy, which is an increase in bulk without an increase in the number of cells.Cellular Adaptation of the intimal layer
Hyaline deposition in the vessel wall
Focal vessel wall necrosisNecrosisThe death of cells in an organ or tissue due to disease, injury or failure of the blood supply.Ischemic Cell Damage
Cerebrovascular amyloid deposition:
Deposition of amyloid proteinsProteinsLinear polypeptides that are synthesized on ribosomes and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of amino acids determines the shape the polypeptide will take, during protein folding, and the function of the protein.Energy Homeostasis between the media and adventitia
Affects small arteriesSmall arteriesArteries: Histology, arteriolesArteriolesThe smallest divisions of the arteries located between the muscular arteries and the capillaries.Arteries: Histology, and capillariesCapillariesCapillaries are the primary structures in the circulatory system that allow the exchange of gas, nutrients, and other materials between the blood and the extracellular fluid (ECF). Capillaries are the smallest of the blood vessels. Because a capillary diameter is so small, only 1 RBC may pass through at a time.Capillaries: Histology
Manifestations include perivascular inflammationInflammationInflammation is a complex set of responses to infection and injury involving leukocytes as the principal cellular mediators in the body’s defense against pathogenic organisms. Inflammation is also seen as a response to tissue injury in the process of wound healing. The 5 cardinal signs of inflammation are pain, heat, redness, swelling, and loss of function. Inflammation, microaneurysms, and fibrinoid necrosisFibrinoid NecrosisCell Injury and Death.
HematomaHematomaA collection of blood outside the blood vessels. Hematoma can be localized in an organ, space, or tissue.Intussusception expansion
Causes a massMassThree-dimensional lesion that occupies a space within the breastImaging of the Breast effect leading to:
Increased intracranial pressureIntracranial PressureIdiopathic Intracranial Hypertension (ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP))
Perilesional edemaEdemaEdema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema
Multiple contributing factors:
MassMassThree-dimensional lesion that occupies a space within the breastImaging of the Breast effect
Perilesional neuronal ischemiaIschemiaA hypoperfusion of the blood through an organ or tissue caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation.Ischemic Cell Damage
CytotoxicCytotoxicParvovirus B19 mediators (i.e., cytokinesCytokinesNon-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Adaptive Immune Response)
May persist for days to weeks after the initial bleeding insult
Decreased perfusion to the perilesional cerebral parenchyma causes a secondary ischemic insult.
Promotes edemaEdemaEdema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema adjacent to the hematomaHematomaA collection of blood outside the blood vessels. Hematoma can be localized in an organ, space, or tissue.Intussusception
Impaired/delayed by the presence of coagulopathy (iatrogenicIatrogenicAny adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.Anterior Cord Syndrome or pathologic)
Impaired/delayed by the presence of severely elevated blood pressure
The signs and symptoms of ICH depend on the anatomical location and size of the hemorrhage.
General symptoms and signs
Symptoms:
Higher likelihood of occurrence and in presenting severely in larger hemorrhages compared with smaller hemorrhages:
HeadacheHeadacheThe symptom of pain in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of headache disorders.Brain Abscess
NauseaNauseaAn unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Antiemetics/vomitingVomitingThe forcible expulsion of the contents of the stomach through the mouth.Hypokalemia
Altered level of consciousness
NeckNeckThe part of a human or animal body connecting the head to the rest of the body.Peritonsillar AbscesspainPainAn unpleasant sensation induced by noxious stimuli which are detected by nerve endings of nociceptive neurons.Pain: Types and Pathways/stiffness
Onset is most common at routine levels of exertion.
Hypertensive bleed: emotional or physical stress/exertion
Smaller/slower bleed: insidious onset of symptoms over minutes
The following findings suggest rapidly progressive neurological impairment due to elevated ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP):
Pupillary palsyPalsyparalysis of an area of the body, thus incapable of voluntary movementCranial Nerve Palsies
Extraocular movement palsyPalsyparalysis of an area of the body, thus incapable of voluntary movementCranial Nerve Palsies
Progressive drowsiness
Cushing triad:
BradycardiaBradycardiaBradyarrhythmia is a rhythm in which the heart rate is less than 60/min. Bradyarrhythmia can be physiologic, without symptoms or hemodynamic change. Pathologic bradyarrhythmia results in reduced cardiac output and hemodynamic instability causing syncope, dizziness, or dyspnea.Bradyarrhythmias
Respiratory depression
HypertensionHypertensionHypertension, or high blood pressure, is a common disease that manifests as elevated systemic arterial pressures. Hypertension is most often asymptomatic and is found incidentally as part of a routine physical examination or during triage for an unrelated medical encounter. Hypertension
Cardiac manifestations
ECGECGAn electrocardiogram (ECG) is a graphic representation of the electrical activity of the heart plotted against time. Adhesive electrodes are affixed to the skin surface allowing measurement of cardiac impulses from many angles. The ECG provides 3-dimensional information about the conduction system of the heart, the myocardium, and other cardiac structures. Electrocardiogram (ECG) abnormalities:
Cardiac enzymesEnzymesEnzymes are complex protein biocatalysts that accelerate chemical reactions without being consumed by them. Due to the body’s constant metabolic needs, the absence of enzymes would make life unsustainable, as reactions would occur too slowly without these molecules. Basics of Enzymes:
CreatineCreatineAn amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine.Acute Kidney Injury kinase-MB (CKMB)
Troponin-I
Troponin-T
Troponin-C
Diagnosis
Intracerebral hemorrhage should be suspected in any individual presenting with neurologic signs or symptoms suggestive of a CVA. Prompt diagnosis is critical, as ICH is associated with significant morbidityMorbidityThe proportion of patients with a particular disease during a given year per given unit of population.Measures of Health Status and mortalityMortalityAll deaths reported in a given population.Measures of Health Status.
Imaging
Noncontrast head CT:
Should be performed emergently
To distinguish between ischemic CVAs and ICH
Findings suggesting rapidly progressive neurological impairment due to elevated ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP):
Ventricular obstruction leading to hydrocephalusHydrocephalusExcessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, intracranial.Subarachnoid Hemorrhage
Intraventricular hemorrhage:
Ventricular enlargement indicating hydrocephalusHydrocephalusExcessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, intracranial.Subarachnoid Hemorrhage
Neurologic deterioration
Supratentorial (hemispheric) hemorrhage:
Neurological deterioration
BrainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and ClassificationcompressionCompressionBlunt Chest Trauma
HydrocephalusHydrocephalusExcessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, intracranial.Subarachnoid Hemorrhage
Follow-up imaging:
Repeat CT/MRI appropriate for:
Evaluation of neurologic deterioration
Confirmation of hematomaHematomaA collection of blood outside the blood vessels. Hematoma can be localized in an organ, space, or tissue.Intussusception stabilization
BrainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and Classification MRI with contrast is the modality of choice to evaluate the underlying cause of ICH.
Digital subtraction angiographyAngiographyRadiography of blood vessels after injection of a contrast medium.Cardiac Surgery (DSA), CTACTAA non-invasive method that uses a ct scanner for capturing images of blood vessels and tissues. A contrast material is injected, which helps produce detailed images that aid in diagnosing vascular diseases.Pulmonary Function Tests, or MRAMRAImaging of the Heart and Great Vessels to evaluate for vascular abnormalities
ElectrolytesElectrolytesElectrolytes are mineral salts that dissolve in water and dissociate into charged particles called ions, which can be either be positively (cations) or negatively (anions) charged. Electrolytes are distributed in the extracellular and intracellular compartments in different concentrations. Electrolytes are essential for various basic life-sustaining functions.Electrolytes
BUN/creatinine
Hepatic transaminasesTransaminasesA subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins.Autoimmune Hepatitis
GlucoseGlucoseA primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Lactose Intolerance
Coagulation studiesCoagulation studiesCoagulation studies are a group of hematologic laboratory studies that reflect the function of blood vessels, platelets, and coagulation factors, which all interact with one another to achieve hemostasis. Coagulation studies are usually ordered to evaluate patients with bleeding or hypercoagulation disorders.Coagulation Studies:
PT and INR
PTT
UrinalysisUrinalysisExamination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.Urinary Tract Infections (UTIs) in Children
Urine toxicology screen
Cardiac evaluation
Baseline ECGECGAn electrocardiogram (ECG) is a graphic representation of the electrical activity of the heart plotted against time. Adhesive electrodes are affixed to the skin surface allowing measurement of cardiac impulses from many angles. The ECG provides 3-dimensional information about the conduction system of the heart, the myocardium, and other cardiac structures. Electrocardiogram (ECG)
Cardiac enzymesEnzymesEnzymes are complex protein biocatalysts that accelerate chemical reactions without being consumed by them. Due to the body’s constant metabolic needs, the absence of enzymes would make life unsustainable, as reactions would occur too slowly without these molecules. Basics of Enzymes to evaluate for myocardial ischemiaMyocardial ischemiaA disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart.Coronary Heart Disease
ElectroencephalographyElectroencephalographySeizures is indicated to evaluate seizuresSeizuresA seizure is abnormal electrical activity of the neurons in the cerebral cortex that can manifest in numerous ways depending on the region of the brain affected. Seizures consist of a sudden imbalance that occurs between the excitatory and inhibitory signals in cortical neurons, creating a net excitation. The 2 major classes of seizures are focal and generalized. Seizures and unexplained encephalopathyEncephalopathyHyper-IgM Syndrome.
A CT scan showing intracerebral hemorrhage with intraventricular extension
Image: “Intracerebral hemorrhage (CT scan). This image shows an intracerebral and intraventricular hemorrhage of a young woman. The woman was one week post partum, with no known trauma involved.” by Glitzy queen00. License: Public Domain
A CT scan showing intracerebral hemorrhage of the basal ganglia with surrounding edema and midline shift
Image: “CT of basal ganglionic hemorrhage” by Shazia Mirza and Sankalp Gokhale. License: CC BY 4.0
Acute ICH is an emergent neurologic situation that may sometimes require surgical intervention. Affected individuals should be managed in the ICUICUHospital units providing continuous surveillance and care to acutely ill patients.West Nile Virus or a dedicated stroke unit. Failure of prompt treatment could result in hemorrhagic expansion, parenchymal brainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and Classification injury, elevated ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP), brainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and ClassificationherniationHerniationOmphalocele, and ultimately death.
Stabilization
Evaluate and stabilize the affected individual using advanced trauma life support (ATLS) or advanced cardiac life support (ACLS) protocols.
Stop/reverse all anticoagulantsAnticoagulantsAnticoagulants are drugs that retard or interrupt the coagulation cascade. The primary classes of available anticoagulants include heparins, vitamin K-dependent antagonists (e.g., warfarin), direct thrombin inhibitors, and factor Xa inhibitors. Anticoagulants/antiplatelet agentsAntiplatelet agentsAntiplatelet agents are medications that inhibit platelet aggregation, a critical step in the formation of the initial platelet plug. Abnormal, or inappropriate, platelet aggregation is a key step in the pathophysiology of arterial ischemic events. The primary categories of antiplatelet agents include aspirin, ADP inhibitors, phosphodiesterase/adenosine uptake inhibitors, and glycoprotein IIb/IIIa inhibitors. Antiplatelet Drugs.
Line placement (peripheral IV, central venous catheterCentral Venous CatheterCentral venous catheters are IV lines placed into the large central veins for monitoring of central venous pressure (CVP), prolonged drug administration, or administration of parenteral nutrition. The most common sites of insertion are the internal jugular and subclavian veins. Central Venous Catheter, arterial line)
Emergent neurosurgical consultation:
Surgical clinical decision-making
Placement of an ICP-monitoring device
Emergent CSF drainage for:
Severely elevated ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP)
Repeat noncontrast CT immediately if deterioration is detected.
Cessation of bleeding:
Stop/reverse anticoagulantsAnticoagulantsAnticoagulants are drugs that retard or interrupt the coagulation cascade. The primary classes of available anticoagulants include heparins, vitamin K-dependent antagonists (e.g., warfarin), direct thrombin inhibitors, and factor Xa inhibitors. Anticoagulants/antiplatelet agentsAntiplatelet agentsAntiplatelet agents are medications that inhibit platelet aggregation, a critical step in the formation of the initial platelet plug. Abnormal, or inappropriate, platelet aggregation is a key step in the pathophysiology of arterial ischemic events. The primary categories of antiplatelet agents include aspirin, ADP inhibitors, phosphodiesterase/adenosine uptake inhibitors, and glycoprotein IIb/IIIa inhibitors. Antiplatelet Drugs.
Order baseline coagulation studiesCoagulation studiesCoagulation studies are a group of hematologic laboratory studies that reflect the function of blood vessels, platelets, and coagulation factors, which all interact with one another to achieve hemostasis. Coagulation studies are usually ordered to evaluate patients with bleeding or hypercoagulation disorders.Coagulation Studies.
Prophylactic measures (to reduce increased ICPIncreased ICPExcessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, intracranial.Subarachnoid Hemorrhage):
Elevate the head of the bed.
Sedate agitated individuals.
Treat feverFeverFever is defined as a measured body temperature of at least 38°C (100.4°F). Fever is caused by circulating endogenous and/or exogenous pyrogens that increase levels of prostaglandin E2 in the hypothalamus. Fever is commonly associated with chills, rigors, sweating, and flushing of the skin. Fever.
Maintain eunatremia (AVOID hypotonicHypotonicSolutions that have a lesser osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.Renal Sodium and Water Regulation fluids).
Osmotic therapy in increased ICPIncreased ICPExcessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, intracranial.Subarachnoid Hemorrhage:
Administration of hypertonic salineHypertonic salineHypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0. 9 g NaCl in 100 ml purified water).Hyponatremia and/or mannitolMannitolA diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.Osmotic Diuretics
Administer prophylactic osmotic therapy:
If severe neurologic impairment on presentation
If rapid neurologic deterioration is detected
If there is a delay in imaging
If neurosurgical evaluation is delayed
HyperventilationHyperventilationA pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.Respiratory Alkalosis:
Induced by manipulation of ventilator settings
Induces cerebral vasoconstrictionVasoconstrictionThe physiological narrowing of blood vessels by contraction of the vascular smooth muscle.Vascular Resistance, Flow, and Mean Arterial Pressure → reduced cerebral blood volume (↓ ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP))
HyperventilationHyperventilationA pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.Respiratory Alkalosis is a temporizing measure reserved for:
Individuals with acute brainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and ClassificationherniationHerniationOmphalocele (until better definitive therapy is available)
Individuals with neurologic deterioration awaiting either urgent surgery or central venous access for osmotherapy
Neurosurgical interventions
Placement of an invasive ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP) monitor:
Intraventricular monitor (gold standard)
Intraparenchymal device
Subarachnoid bolts
Neurosurgical consultation (to consider emergent surgery) for the following:
Hemispheric ICH with brainBrainThe part of central nervous system that is contained within the skull (cranium). Arising from the neural tube, the embryonic brain is comprised of three major parts including prosencephalon (the forebrain); mesencephalon (the midbrain); and rhombencephalon (the hindbrain). The developed brain consists of cerebrum; cerebellum; and other structures in the brain stem.Nervous System: Anatomy, Structure, and ClassificationcompressionCompressionBlunt Chest Trauma or obstructive hydrocephalusObstructive HydrocephalusHydrocephalus in Children
Craniectomy with hematomaHematomaA collection of blood outside the blood vessels. Hematoma can be localized in an organ, space, or tissue.Intussusception evacuation
Other potential interventions:
CraniotomyCraniotomySurgical incision into the cranium.Neurosurgery with endoscopic hemorrhage aspiration
CT-guided stereotactic aspiration
Blood pressure control
Blood pressure elevation may be the cause of hemorrhage.
Conversely, increased ICPIncreased ICPExcessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, intracranial.Subarachnoid Hemorrhage may cause blood pressure elevation.
Elevated blood pressure may be necessary to maintain cerebral perfusionCerebral PerfusionSyncope in the setting of cerebral edemaCerebral edemaIncreased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries. An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive hydrocephalus).Increased Intracranial Pressure (ICP).
PainPainAn unpleasant sensation induced by noxious stimuli which are detected by nerve endings of nociceptive neurons.Pain: Types and Pathways due to ICH may also contribute to blood pressure elevation.
BP goals (when clinically stable):
Acute ICH with systolic BP (SBPSBPAscites) of 150–220 mm Hg: Lower to a target of 140 mm Hg.
Systolic blood pressure ≥ 160 mm Hg: nicardipineNicardipineA potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.Class 4 Antiarrhythmic Drugs (Calcium Channel Blockers)
Systolic blood pressure < 160 mm Hg: labetalolLabetalolA salicylamide derivative that is a non-cardioselective blocker of beta-adrenergic receptors and alpha-1 adrenergic receptors.Subarachnoid Hemorrhage
Seizure management
Individuals with ICH often experience seizuresSeizuresA seizure is abnormal electrical activity of the neurons in the cerebral cortex that can manifest in numerous ways depending on the region of the brain affected. Seizures consist of a sudden imbalance that occurs between the excitatory and inhibitory signals in cortical neurons, creating a net excitation. The 2 major classes of seizures are focal and generalized. Seizures:
Early seizuresSeizuresA seizure is abnormal electrical activity of the neurons in the cerebral cortex that can manifest in numerous ways depending on the region of the brain affected. Seizures consist of a sudden imbalance that occurs between the excitatory and inhibitory signals in cortical neurons, creating a net excitation. The 2 major classes of seizures are focal and generalized. Seizures in the course of management:
Attributed to acute neurochemical changes associated with ICH
Status epilepticusStatus EpilepticusA prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition. Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity.Seizures during the course of management
Late seizuresSeizuresA seizure is abnormal electrical activity of the neurons in the cerebral cortex that can manifest in numerous ways depending on the region of the brain affected. Seizures consist of a sudden imbalance that occurs between the excitatory and inhibitory signals in cortical neurons, creating a net excitation. The 2 major classes of seizures are focal and generalized. Seizures after ICH stabilization:
Usually recurrent and also known as “post-stroke epilepsyEpilepsyEpilepsy is a chronic brain disorder marked by recurrent and unprovoked seizures. These seizures can be classified as focal or generalized and idiopathic or secondary to another condition. Clinical presentation correlates to the classification of the epileptic disorder. Epilepsy”
Acute (early) ICH-related seizuresSeizuresA seizure is abnormal electrical activity of the neurons in the cerebral cortex that can manifest in numerous ways depending on the region of the brain affected. Seizures consist of a sudden imbalance that occurs between the excitatory and inhibitory signals in cortical neurons, creating a net excitation. The 2 major classes of seizures are focal and generalized. Seizures: immediate IV administration of antiepileptics
Post-stroke (late) seizuresSeizuresA seizure is abnormal electrical activity of the neurons in the cerebral cortex that can manifest in numerous ways depending on the region of the brain affected. Seizures consist of a sudden imbalance that occurs between the excitatory and inhibitory signals in cortical neurons, creating a net excitation. The 2 major classes of seizures are focal and generalized. Seizures: long-term antiepileptic therapy
PrognosisPrognosisA prediction of the probable outcome of a disease based on a individual’s condition and the usual course of the disease as seen in similar situations.Non-Hodgkin Lymphomas
MorbidityMorbidityThe proportion of patients with a particular disease during a given year per given unit of population.Measures of Health Status:
Residual neurologic impairment and associated disabilityDisabilityDetermination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for social security and workman’s compensation benefits.ABCDE Assessment
Cognitive impairment
Risk factors for poor outcomes:
Advanced age
Severe baseline neurologic impairment
Early neurologic deterioration
PrematurePrematureChildbirth before 37 weeks of pregnancy (259 days from the first day of the mother’s last menstrual period, or 245 days after fertilization).Necrotizing Enterocolitis or early withdrawal of support
Use of anticoagulantsAnticoagulantsAnticoagulants are drugs that retard or interrupt the coagulation cascade. The primary classes of available anticoagulants include heparins, vitamin K-dependent antagonists (e.g., warfarin), direct thrombin inhibitors, and factor Xa inhibitors. Anticoagulants/antiplatelet agentsAntiplatelet agentsAntiplatelet agents are medications that inhibit platelet aggregation, a critical step in the formation of the initial platelet plug. Abnormal, or inappropriate, platelet aggregation is a key step in the pathophysiology of arterial ischemic events. The primary categories of antiplatelet agents include aspirin, ADP inhibitors, phosphodiesterase/adenosine uptake inhibitors, and glycoprotein IIb/IIIa inhibitors. Antiplatelet Drugs
HematomaHematomaA collection of blood outside the blood vessels. Hematoma can be localized in an organ, space, or tissue.Intussusception characteristics:
Ischemic strokeIschemic StrokeAn ischemic stroke (also known as cerebrovascular accident) is an acute neurologic injury that occurs as a result of brain ischemia; this condition may be due to cerebral blood vessel occlusion by thrombosis or embolism, or rarely due to systemic hypoperfusion. Ischemic Stroke: an ischemic infarctInfarctArea of necrotic cells in an organ, arising mainly from hypoxia and ischemiaIschemic Cell Damage of the cerebral parenchyma caused by the occlusion of a cerebral artery by atherosclerotic lesions or cardioembolic emboli. Ischemic strokeIschemic StrokeAn ischemic stroke (also known as cerebrovascular accident) is an acute neurologic injury that occurs as a result of brain ischemia; this condition may be due to cerebral blood vessel occlusion by thrombosis or embolism, or rarely due to systemic hypoperfusion. Ischemic Stroke presents with neurologic deficitsNeurologic DeficitsHigh-Risk Headaches and/or altered mental statusAltered Mental StatusSepsis in Children/altered level of consciousness that depends on the size and location of the infarctInfarctArea of necrotic cells in an organ, arising mainly from hypoxia and ischemiaIschemic Cell Damage. Diagnosis is clinical and confirmed by neuroimagingNeuroimagingNon-invasive methods of visualizing the central nervous system, especially the brain, by various imaging modalities.Febrile Infant. Management includes initial stabilization, possible cerebrovascular intervention, and addressing identifiable underlying etiologies (severe hypertensionSevere hypertensionA confirmed blood pressure ≥ 180 mm Hg systolic and/or ≥ 120 mm Hg diastolic.Uncontrolled Hypertension, embolus), and cardiovascular risk factors.
Other hemorrhagic cerebral conditions: Carotid/cerebral artery dissection, epidural hemorrhageEpidural HemorrhageEpidural hemorrhage (EDH) is an event characterized by bleeding into the epidural space between the dural layers of the meninges and the skull. The primary mechanism triggering bleeding is trauma (i.e., closed head injury), which causes arterial injury, most commonly middle meningeal artery injury. Epidural Hemorrhage, intraparenchymal hemorrhage, and subdural hemorrhageSubdural HemorrhageSubdural hemorrhage (SDH) is bleeding into the space between the dural and arachnoid meningeal layers surrounding the brain. The most common mechanism triggering the bleeding event is trauma (e.g., closed head injury) causing a tearing injury to the extracerebral “bridging” veins.Subdural Hemorrhage are other hemorrhagic manifestations of the cerebral vasculature that can present with neurologic deficitsNeurologic DeficitsHigh-Risk Headaches and/or altered mental statusAltered Mental StatusSepsis in Children/altered level of consciousness. Diagnosis is clinical and confirmed by neuroimagingNeuroimagingNon-invasive methods of visualizing the central nervous system, especially the brain, by various imaging modalities.Febrile Infant. Management depends on the hemorrhagic etiology and includes initial stabilization, neurosurgical/endovascular consultation, management of ICPICPNormal intracranial pressure (ICP) is defined as < 15 mm Hg, whereas pathologically increased ICP is any pressure ≥ 20 mm Hg. Increased ICP may result from several etiologies, including trauma, intracranial hemorrhage, mass lesions, cerebral edema, increased CSF production, and decreased CSF absorption.Increased Intracranial Pressure (ICP), and monitoring in a neurologic ICUICUHospital units providing continuous surveillance and care to acutely ill patients.West Nile Virus.
Aguilar, M.I., Brott, T.G. (2011). Update in intracerebral hemorrhage. The Neurohospitalist, 1, pp. 148–159. Retrieved September 22, 2021, from https://doi.org/10.1177/1941875211409050
Greenberg, S.M., et al. (2022). 2022 guideline for the management of patients with spontaneous intracerebral hemorrhage: A guideline from the American Heart Association/American Stroke Association. Stroke, 53: e282-e361. https://www.ahajournals.org/doi/full/10.1161/STR.0000000000000407
Create your free account or log in to continue reading!