Principles of Bioenergetics and Fuel Molecule Metabolism

To the point. Good organized pathway explanations. Pedagogical presentation skills.

Dr. Ahern is amazing at linking what he's about to teach to previous videos.

The video by Lecturio provides an excellent overview of the electron transport chain and chemiosmosis, two of the most important metabolic processes in the cell. These processes work together to produce ATP, the cell's energy currency. One of the most interesting things about the electron transport chain is that it is a highly efficient way to convert energy from food into ATP. The chain uses the energy from NADH and FADH2, two electron carriers that are produced during glycolysis and the Krebs cycle, to pump protons across the inner mitochondrial membrane. This creates a proton gradient, which is like a dam holding back a reservoir of energy. The ATP synthase enzyme then uses the energy of the proton gradient to drive the synthesis of ATP from ADP and inorganic phosphate. This process is called chemiosmosis. The video does a great job of explaining the complex steps of the electron transport chain and chemiosmosis in a clear and concise way. It also provides helpful animations and diagrams that illustrate the process.

I've reviewed the Video, and while it provides a comprehensive overview, there are a few points that need clarification. "Fatty acid synthesis doesn't occur in the mitochondrion; it occurs in the cytoplasm, sequestered from fatty acid oxidation, simplifying the regulation of the two pathways." Clarification: Fatty acid synthesis indeed occurs in the cytoplasm, separate from fatty acid oxidation that takes place in mitochondria. This separation allows for streamlined regulation, ensuring the balance between synthesis and breakdown. "Fatty acid synthesis is chemically similar to the reverse of oxidation, involving joining, reduction, loss of water, and a final reduction, making it essentially the reverse of oxidation." Clarification: Fatty acid synthesis does indeed involve joining of acetyl and malonyl units, reduction steps, and removal of water, making it similar but not exactly the reverse of oxidation. The subtle differences in the chemical steps are crucial for the controlled synthesis of fatty acids. "The enzyme acetyl-CoA carboxylase is regulated through phosphorylation by AMP-activated protein kinase and allosteric binding of citrate, ensuring the balance between synthesis and cellular energy levels." Clarification: Acetyl-CoA carboxylase, a key enzyme in fatty acid synthesis, is indeed regulated through phosphorylation and allosteric binding of citrate. This regulation allows cells to respond to energy demands, modulating fatty acid production accordingly. "Fatty acid synthesis involves a series of steps catalyzed by the multifunctional enzyme fatty acid synthase, where individual activities within the enzyme complex work together, ensuring efficient fatty acid production." Clarification: Fatty acid synthase, a multi functional enzyme complex, plays a central role in fatty acid synthesis. Its individual activities work in harmony within the complex, allowing for the sequential addition of carbon units and the creation of fatty acids up to 16 carbons in length.

The following are the errors in the information you provided: 00:24 The general formula for monosaccharides is Cx(H2O)x, where x is equal to the number of carbon atoms in the monosaccharide. For example, the structural formula for glucose is C6H12O6, which means that it has six carbon atoms and six water molecules. 01:15 The structural formula for lactose is C12H22O11. This means that it is a disaccharide made up of two monosaccharides, glucose and galactose. 01:39 Polysaccharides are polymers of monosaccharides, but they do not necessarily have to have the same repeating sugar unit throughout. For example, amylopectin is a polysaccharide made up of glucose molecules, but it has a branched structure. Here is a corrected version of the information you provided: Carbohydrates are molecules whose name literally means hydrates of carbon. This is because monosaccharides, the simplest carbohydrates, have a ratio of one carbon atom to two hydrogen atoms to one oxygen atom, the same as water. The general formula for monosaccharides is Cx(H2O)x, where x is equal to the number of carbon atoms in the monosaccharide. For example, the structural formula for glucose is C6H12O6, which means that it has six carbon atoms and six water molecules. Disaccharides are carbohydrates that are made up of two monosaccharides. They are formed by a glycosidic linkage between the two monosaccharides. Disaccharides have the general formula C12H22O11. Examples of disaccharides include sucrose (glucose + fructose), lactose (glucose + galactose), and maltose (glucose + glucose). Polysaccharides are carbohydrates that are made up of many monosaccharides. They are formed by glycosidic linkages between the monosaccharides. Polysaccharides have the general formula (C6H10O5)n, where n is the number of monosaccharides in the polysaccharide. Examples of polysaccharides include cellulose, starch, glycogen, and chitin. Polysaccharides do not necessarily have to have the same repeating sugar unit throughout. For example, amylopectin is a polysaccharide made up of glucose molecules, but it has a branched structure.

Great Lecturer..well explained. Every section of lectures are meticulously explained. Clearly understood.

it's very easy and simply explained and I loved it It was very helpful

Clear and understandable concept with actual molecules shown aswell which is very helpful.

not explned wel as the topic is difficult and you made it a lot much boring

I have really learned. Before, I was wondering why study, or cram all those pathways and enzymes. How Professor Kevin Ahern explains and bring out concepts, Oh my God so great. He was born a teacher and just polished by learning! He never leaves behind any one, even the slow learners can pick, because once one understands the basic, the necessary complex facts can be understood quite faster! I am now thinking of mastering in Biochemistry, besides my goal of Internal medicine. To be the best Physician, Biochemistry I have understood is one of the vital tools! In my Nursing practice, we lost a 10 yr old male with Liver Cirrhosis from a liver disease, which was diagnosed in early age. Now, I am thinking of a Deficiency of the Transaldolase enzyme!! Ahh save for my little knowledge! Kind regards!

Really a great and elaborate presentation. Thanks Prof. Kevin. Now I no longer struggle in cramming Biochemistry but rather find the subject interesting. I wish I started using your lecture guide early in Medical school, but any way not yet late! Thank you once again.

very new insight to explain macronutrient and fruit for thought

Very dense lecture. Maybe a bit too in-depth in some places, but excellent discussion about the importance of carbohydrates and the key enzymes and reactions that underly the process.

Awesome lectures by Sir. he explain every step and every single reaction with detail thank u.

I can easily follow the sequence of information. The important details are also emphasized, making it easier for recall.

I really like the explanations and detailed structures used. The structures make it easier to understand.

Very clear and easy to understand. I enjoyed the visuals.

The explanation about the carbs are very clear and detail. Which make easier for any student and professor to better understand the carbs, their pathway, and the enzymes that work in those pathways.

Concepts are very good and explanation is amazing. I'm in love with it

Amazing Dr. Kevin! Thank you very much for this course!

They give clear explanations on all topics in such a way that it is easier to grasp. I personally enjoy learning more about a particular topic and Lecturio is the perfect platform to do that as well. I highly recommend Lecturio to all students for better understanding of relevant topics.

I honestly had a lot of fun listening to Professor Ahern. You can tell he is really passionate about Biochem. I learned a lot. Great course if you're interested in understanding aspects of the metabolic pathways conceptually while appreciating the details/context that enrich your understanding of them and how they are interrelated.

Comprehensive course with exemplary format & teaching style to explain core concepts.

fast confusing order of explaining Its not like it simlifies anything the way its explained is quite fast and confusing very mono tone

I love her course. She explains in a very understandable way.

I am no longer scared of metabolic pathways. thank you so much.

Its excellent because there is more physical and clinical correlation and enzyme mechanism simplified

I noticed that there weren't any lectures on mineral metabolism in the library. I think students would really appreciate it if you made a module on this topic as it has a lot of biomedical importance and some relevant diseases are associated with it.

Each and every concept is explained with each lecture it has helped me in getting to know things well rather than just learning.

Dr. Ahern pointed out very interesting aspects like heat generation/high energy of PEP and the 2,3-BPG production. Maybe I wasn't paying attention the first time I learned about glycolysis, but this extra integrative information it makes this step easier to remember. Actually, in generally, these human focused biochemistry lectures, are easier to digest, since when I learned it originally, it was mixed with plant and microbial biochem.

Prof Ahern explains very well & makes the key steps/enzymes memorable (eg PEP is full of pep!)

So good explications with a nice and simple way . I really appreciate your effort .

Magnificent lecture about polysaccharides and their functions for storage and release

It's unfathomable how much this lecture has saved my time. Though I would appreciate a quick-summary of the products turning into intermediates for other cycles. Like with how g-1-p turns into g-6-p

The lecture simplified glycogenesis to extreme simplicity. It truly helped save around 30 minutes from my lecture, by providing adequate information

very clear explanations and the questions helped me understand the content

It's good, informative not as detailed as I need it to be but it's a good framework to build on

Concise and clear; exactly what I needed for this topic, thank you.

This lecture is amazing and I loved the explanation regarding the conformational change of hexocinase during the reaction.

Teacher speak slowly to help me understand Glucose in my body

me gusto muchísimo lo recomiendo a todo el mundo que quiera saber mas

Dr. Cornwall did a very great job with this.. The big picture simplified everything and made studying into little details easy.

Whenever I get confused about a pathway, I come to watch these videos and it helps tremendously. Thank you for what you do.

Great lecture! Very simplified and friendly explained. Thanks so much !

I find the teaching style to be effective and well planned. I use lecturio for supplimenting the topics taught in my classes

Very insightful and brilliant explanation. I learned very much in this lecture! School professor just skip much of the importance in PPP!

I believe the term is entropy is misused in this lecture.

Excellent lecture. Understood Bohr effect better than ever. I love these lectures.

This videos are amazing, the professor is excellent and his explications are clear

He is a very Good Teacher as he teaches as if he was narrating a story.

Awesome analogy great lecture! Very nice lectures overall I really enjoyed them. even though I have taught this topics and I know them fairly well. I enjoy little gems of information I received through these lectures, and new understanding

Amazing explanation made me understand the concept clearly in a short time

I like how Dr. Cornwall recaps chemistry and relation to energy to cells. Her hand motions help with my learning and understanding. Thank you.

Great professor. Has almost everything needed for my course in Biochemistry.

I like the practical comparisons used for better understanding and remembering the topic, makes it much easier and more entertaining!

Muy buen docente, se nota que le apasiona su profesion y la ejerce con entusiasmo.

A huge thank you to Prof Ahern! You explanations are very easy to understand and your lectures are a huge help to get a better understanding of biochemistry topics. Thank you very much!

Really good discussion. I would love Dr. Ahern to by my mentor

its good and thorough, also covers minor lipid types! good to learn

A+ teaching style and delivery thank you Dr Ahern for making a difficult topic easier to digest

This lecture was explained super clear and to the point. Thank you!

amazing ! thank you so much dear dr.Ahern , i was always scared of biochemistry ,but its the first time i finally get to understand it and i owe it all to you. My committee exam will be in two weeks and im hoping to finish this course plus few more lectures from fat metabolism course. also special thanks to lecturio for preparing such a great learning system opportunity for us.

I'll just say thank you very very very very much!!!

Love him so far, clear concise and to the point and also very enlightening

As much as your stories are interesting for the ETC gradient It does not fit my learning style. It would be nice to have clear scientific language about what's happening. I can't write a story on my exam paper. Perhaps this is just me.

Easy to understand and very complete. Thank you for your time, helped me a lot

Very nice and informative lecture, easy to understand and remember

I have followed Dr Ahern through all the basics of biochem lectures and he has never failed to deliver.

You make it much more easier. However, I still understand all important points. Thank you!

This entire series is the most eloquent and beautiful explanation of a terrible terrible subject like biochemistry I have ever seen to attended

Really great explanations of the whole process. Was not happy that I had to relearn Krebs and ETC but actually found these videos enjoyable and valuable.

Great enzyme analogy! Enzyme is the friend who puts his two other friends in contact with each other so that they can start talking and dating ;)

Had so much difficulty learning the enzymes on the pathways. This way was easy to understand it!!

He explains it very well and at a good speed. He doesn't use to many difficult words so if your first language isn't english it's still possible to understand. Also whenever you have a question he answers quickly en thouroughly.

Great lecturer very knowledgeable of subject matter at an admirable pace. Needed this in depth type of lecture in med sch. Good job

Gooood job LoL and really a good story-maker????Thank you very much! Amazing, very impressive!

I do not think there can be any simpler explanation of these concepts. Dr. Cornwall takes her time to explain these concepts in a way that they stick with you, and the analogies she uses engrave them into the medulla so that you can relate to the concept. You can't beat this! This is exceptional!!!! Thank you so much!!

This guy just knows his stuff, on point even with the speed of his speech he has mastered his slides. I almost got scared with the previous lecture in genetics but he managed to bring me back home. Very knowledgeable keep up the good work and add more clinical correlations.

It was simply amazing. The knowledge I got exposed to was simply clear cut and delivered by an expert in layman's literature. I am keen to absorb more of Mr. Kevin Ahern's lectures.

Batalle mucho para entnder mis clases pero con estén curso tengo un mejor dominio de el metabolismo y me permitió realizar una presentacion del tema ????

Recommend this course to any medical students doing pre/clinical Helps with pathways and understanding breakdown.

Excellent! Well delivered and full of quality information. Totally recommend this course.

I don't waste my time going to any biochemistry lectures at my medical school because I know that Dr Cornwall explains all of the content more clearly, in more depth, in less time. I always finish her lectures excited for the next one!

The subject is really hard... but the professor is excellent!

A great lecture. I am a high school student and i struggle with biology. I get a better explanation from your lectures and I am not even a native English speaker. Thank you so much!

Thank you Dr Ahern! Thanks to your clear and nice explanations With integrations I am finally starting to understand Biochem! You make difficult things look so simple and enhances the importance and intelligence of mother nature in our human bodies

Incredibly good! I have spent hours studying from the book and this is by far the most helpful in terms of deep,meaningful understanding of the subject.

Professor Dr. Kevin Ahern is very clear in presenting. Love the short but very informative lectures. Would recommend to everyone, those with or without biochemistry understanding. Thank you very much Professor and Thanks to the maker of Lecturio.

Very clear summary. Would like to see more clinical correlations made.

Awesome job, I wish you were my teacher at my university! So clear!

I subscribe because of this professor. Great lectures and explanation. Nice job

What I loved the most about this lecture was how Dr. Cornwall actually took her time to explain the concepts discussed, and even used simple analogies to ensure that the information was easier to digest. This is something you find lacking in many professional lectures. Thanks again Dr. Cornwall!

Great professor, great explanations. This video was like a summary of important parts.

Exactly what I needed. Straightforward and to the point. Linearly organized.

Hello though I learnt new things by the good explanation of the pathway but I will be happy if there could be mnemonics to remember then easily. Thanks