Diabetes Insipidus (DI)

by Carlo Raj, MD

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    Continuing our discussion on the concentration of urine. Up until now, we looked at ADH, looked at its control and then went into SIADH in great detail. Now let us take a look at diabetes insipidus, the opposite of but nonetheless an important difference to keep in mind when you have plasma and urine osmolarity at hand. So we have nephrogenic diabetic insipidus. Now what we will do here ladies and gentleman is under renal or nephrology, we will strictly only be managing nephrogenic diabetic insipidus. I want to make sure that we are clear because there is no important piece of information that is left out in your lecture series with me. The central diabetes insipidus, we will be dealing with that in endocrinology. Is that clear? So here let us keep things relevant and all that I will bring to your attention is the pathology of diabetes insipidus, nephrogenic in the category of nephrology. With that said, let us continue and before we move on, though, let us talk about the basic definition and predict as to what is going to happen in our patient with nephrogenic diabetes insipidus. Nephrogenic that means there is a problem with the kidney in which ADH is not working properly. Now just to make sure we are clear. If you have a patient that has SIADH maybe perhaps secondary to small cell lung cancer. We talked about that in great detail. Then you would purposely induce nephrogenic diabetes insipidus by giving a drug such as demeclocycline so that you can deal with SIADH. However now we will come to the actual primary disease of nephrogenic diabetes insipidus. There is not going to be your V2 receptors working properly. You are not going to be able to properly reabsorb your water. If that...

    About the Lecture

    The lecture Diabetes Insipidus (DI) by Carlo Raj, MD is from the course Renal Pathology. It contains the following chapters:

    • Nephrogenic Diabetes Insipidus
    • Etiology of Nephrogenic Diabetes Insipidus
    • Actions of ADH
    • Management of Nephrogenic Diabetes Insipidus
    • Differentials

    Author of lecture Diabetes Insipidus (DI)

     Carlo Raj, MD

    Carlo Raj, MD

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