Vasculitis (literally meaning “inflammation of vessels”) refers to a group of disorders that share clinical, laboratory, and pathophysiologic findings. The type of blood vessel affected and the site(s) of involvement are variable and influence clinical features of each specific subtype of the disorder. Vasculitis may occur as a primary process or may also be secondary to another underlying disease. Primary systemic vasculitides, in which the vasculitis is not secondary to some underlying disease, are often multisystem disorders that many different specialists need to be aware of. Recognizing the constellation of symptoms specific to various vasculitides may help save someone’s life.