Tumors induce changes throughout the body, such as an increase in coagulability, electrolyte dysregulation, and antibody formation leading to paraneoplastic syndromes. In paraneoplastic syndromes, the malignant cells do not directly cause symptoms related to metastasis; rather, they generate autoantibodies, cytokines, hormones, or peptides that affect multiple organ systems. In addition, the treatment of cancer often targets rapidly dividing cells or, in some cases, the immune system, which can lead to significant morbidity from unintended side effects. All of these factors contribute to why cancer is such a devastating diagnosis with often poor outcomes.
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