Thrombosis and anti-thrombotic therapy

by Paul Moss, PhD

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    Hello, Welcome to this lecture on thrombosis and antithrombotic therapy. We will see in this lecture thrombosis is one of the most important problems in medicine at the current time. Some people carry an inherited predisposition to venous thrombosis and environmental risk factors include bed rest or surgery. Arterial thrombosis is primarily the result of atherosclerosis and heparin and warfarin have been mainstays of anti-thrombotic therapy, but a range of new oral agents are now available. Let us introduce thrombosis. Thrombi are plugs consisting primarily of platelets and fibrin and, of course, the main clinical problem that arises from this is ischemia, lack of blood supply that happens beyond the clot. Now thrombi may occur in either the arterial or the venous circulation and an important is thrombophilia that refers to the inherited predisposition to thrombosis. On the right, you will see a very large thrombus in the pulmonary veins. Let us start by discussing arterial thrombosis. These arise on areas of atherosclerosis particularly when there is plaque rupture. When the plaques formed enough respiratory break and platelet adhere to that site. A platelet adhesion, aggregation and release may actually serve to promote the development of atherosclerotic lesions and that might be one reason why aspirin is so effective in reducing the risk of atherosclerotic events. But as well as ischemia, thrombosis may also lead to the release of emboli, the flow to downstream vessels sometimes seen from atherosclerotic plaques in the neck leading to emboli into the brain. Atherosclerosis is being one of the major problems in human health over the last few decades and we know a lots about the risk factors cholesterol, hypertension and smoking. There is some good news here because the incidence and also the mortality from atherosclerotic disorders has increased markedly in recent years...

    About the Lecture

    The lecture Thrombosis and anti-thrombotic therapy by Paul Moss, PhD is from the course Hematology: Advanced. It contains the following chapters:

    • Thrombosis
    • Anticoagulant Drugs

    Quiz for lecture

    Test your knowledge with our quiz for lecture Thrombosis and anti-thrombotic therapy.

    1. Swelling, tenderness and warmth in the lower leg
    2. Angina
    3. Decreased D-dimer concentrations in blood
    4. Sudden onset of cold and blue toes in the foot
    5. Purpura on the limbs
    1. Low molecular weight heparin
    2. Warfarin
    3. Streptokinase
    4. Rivaroxaban
    5. Aspirin
    1. Factor V Leiden makes the protein easier to cleave by activated protein C.
    2. Up to 30% of patients with venous thrombosis have a genetic predisposition to thrombosis.
    3. Activated protein C inactivates the activated forms of factors V and VIII.
    4. Homozygotes for factor V Leiden have a 30-140 increased risk of thrombosis.
    5. Protein S is a co-factor for protein C.

    Author of lecture Thrombosis and anti-thrombotic therapy

     Paul Moss, PhD

    Paul Moss, PhD

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