by Paul Moss, PhD

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    Hello, Welcome to this lecture on the important topic of lymphoma. In this lecture, you will learn a number of important points. In lymphoma, the malignant lymphoid cells accumulate in the lymphoid tissue rather than blood. There are two broad sub-types of lymphoma - Hodgkin lymphoma and non-Hodgkin lymphoma. Hodgkin lymphoma is diagnosed by the presence of the Reed-Sternberg cells whereas non-Hodgkin's lymphomas are an extremely heterogeneous group of disorders. Lymphoma is a disorder of malignant lymphoid cells, but in lymphoma these cells accumulate in lymphoid tissue whereas in leukemia they are mainly in the bone marrow and blood. If you look at the slide on the right, you will see that this patient has a very large lymphoid node mass in the neck. The incidence of lymphoma is the increasing, particularly non-Hodgkin lymphoma. We really do not know the epidemiology behind this trend. The treatments of lymphoma depend on the accurate diagnosis of the disease subtype and during this lecture, we will spend time working out how to make the correct diagnosis. Let us start with Hodgkin lymphoma. This disorder was described by Thomas Hodgkin in 1832. He worked at . . . Guy's Hospital in London and on the right this very beautiful drawing shows the original description of Hodgkin lymphoma from that time and it actually shows one of the major features of Hodgkin lymphoma, which tends to spread down the lymphatic system, in this case from the neck into the axillary lymph nodes. The most common presentation of Hodgkin lymphoma is within large lymph nodes usually in the neck and as I said from the picture, it tends to spread through the lymphatic system rather than through other tissues. There may be additional symptoms, which are important in staging Hodgkin lymphoma. These are fatigue, weight loss,...

    About the Lecture

    The lecture Lymphoma by Paul Moss, PhD is from the course Hematology: Advanced. It contains the following chapters:

    • Hodgkin Lymphoma
    • Non-Hodgkin Lymphomas
    • Other Types of Lymphoma

    Included Quiz Questions

    1. It expresses CD35+
    2. It is a ‘crippled’ B cell
    3. It has very prominent nucleoli
    4. It defines the diagnosis of Hodgkin lymphoma
    5. It expresses CD15
    1. Stage A means that systemic features are present.
    2. Swelling of lymph nodes in only one region is stage I.
    3. Stage III refers to disease above and below the diaphragm.
    4. Systemic features include fever or weight loss.
    5. Involvement of the spleen or bone marrow would define stage IV.
    1. Hodgkin Lymphoma
    2. Follicular Lymphoma
    3. Mantle cell Lymphoma
    4. Lymphoplasmacytic Lymphoma
    5. Burkitt Lymphoma

    Author of lecture Lymphoma

     Paul Moss, PhD

    Paul Moss, PhD

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    Great free lectures!
    By Karen K. on 23. April 2016 for Lymphoma

    Great free lectures! Thank you !