DNA Replication & DNA Repair

by Kevin Ahern, PhD

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    About the Lecture

    The lecture DNA Replication & DNA Repair by Kevin Ahern, PhD is from the course Biochemistry: Advanced. It contains the following chapters:

    • DNA Replication
    • DNA Polymerase
    • Other Replication Proteins
    • Replication Fork
    • Leading & Lagging Strand
    • Telomeres
    • DNA Repair

    Quiz for lecture

    Test your knowledge with our quiz for lecture DNA Replication & DNA Repair.

    1. ...is always made in the 5’ to 3’ direction.
    2. ...has bases on the outside and the backbone on the inside.
    3. ...has a peptide bond backbone.
    4. ...has covalent bonds between bases of the duplex.
    1. ...requires a DNA polymerase.
    2. ..starts at a promoter.
    3. ...uses a helicase to relieve tension.
    4. ...requires breaking of phosphodiester bonds on DNA strands.
    1. ...comes from the 3’ to 5’ exonuclease activity of some DNA polymerases.
    2. ...involves changes in the parent DNA strand.
    3. ...is present on all DNA polymerases.
    4. ...is due to a 5’ to 3’ exonuclease activity of a DNA polymerase.
    1. It works mostly on the leading strand.
    2. It has three enzymatic activities.
    3. It does proofreading.
    4. It has a hand-like structure.
    1. Increases when the enzyme remains on the enzyme for a longer period of time.
    2. ...refers to how fast it completes a process.
    3. ...increases when the enzyme moves to different strands rapidly.
    4. ...is destabilized by the beta clamp.
    1. It has high fidelity.
    2. It is a DNA polymerase in retroviruses.
    3. It uses RNA as a template to make DNA.
    4. It uses deoxyribonucleotides.
    1. ...operates at about 6000 rpm.
    2. ...is found behind the DNA polymerase.
    3. ...assists in re-winding of the DNA after the replication fork passes.
    4. ...helps base pairs to form.
    1. Lagging strand replication is continuous.
    2. Primase is responsible for making the primer necessary to start the process.
    3. DNA Polymerase I removes the RNA primer.
    4. DNA ligase joins together Okazaki fragments.
    1. ...occur mostly on the lagging strand.
    2. ...refer to the short RNA primers used to start DNA replication.
    3. ...are made 3’ to 5’.
    4. ...are not found in eukaryotic cells.
    1. ...are short repeated sequences at the ends of eukaryotic chromosomes.
    2. ...grow in length with each round of replication.
    3. ...are created and destroyed by the enzyme known as telomerase.
    4. ...are made by repeatedly copying a short DNA template.
    1. ...makes telomeres by repeated copying a short RNA.
    2. ...is active in almost every cell.
    3. ...makes cells cancerous when it is inhibited.
    4. ...uses an RNA primer.
    1. ...it requires unusual DNA polymerases.
    2. ...deficiencies in it are linked to human cancer.
    3. ...it can cut out damaged bases.
    4. ...it can fix thymine dimers.

    Author of lecture DNA Replication & DNA Repair

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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