Connective Tissue Diseases
Connective Tissue Diseases

Connective Tissue Diseases

by Stephen Holt, MD, MS

Connective tissue diseases are a broad category that includes many familiar disorders (e.g. systemic lupus erythematosus, scleroderma) as well as others that are more obscure. They are all characterized by the production of autoantibodies and involve immune dysfunction. It is sometimes difficult to categorize patients clearly, as connective tissue diseases share clinical and laboratory findings. It is not uncommon for patients to present with multiple overlapping disorders.

Connective tissue disorders are often considered systemic and tend to involve many organ systems, thus making it extremely important for every physician to be aware of their manifestations. For example, SLE may affect the skin, CNS, heart, lungs, kidneys, and hematopoiesis, among others. Any one of these organs may be the first clinically recognizable manifestation of disease, and prompt therapy can be lifesaving. For such patients, the clinician should obtain a basic history and review of systems, conduct a basic physical examination and laboratory workup, and understand when a rheumatology referral may be appropriate.

Course Details

  • Videos 17
  • Duration 1:27 h
  • Quiz questions 43
  • Concept Pages 6


Your Educators of course Connective Tissue Diseases

 Stephen Holt, MD, MS

Stephen Holt, MD, MS

Dr. Stephen Holt is the Associate Program Director for Ambulatory Education in the Primary Care Program at the Yale School of Medicine in Connecticut, USA.
He obtained his PhD from Columbia College of Physicians and Surgeons in 2004. Currently, he is Director of the Addiction Recovery Clinic and Codirector of Clinician Educator Distinctions Pathway at Yale School of Medicine.
Because of his achievements, he earned the Faculty Teacher of the Year award from the Yale Primary Care Residency Program in 2009 and 2017.
Within Lecturio, Dr. Holt teaches courses on Physical Examination, Dermatology, and Rheumatology.

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Easy to understand this difficult medical field
By Hilda Maria P. on 11. January 2024 for Inflammatory Myopathies: Types, Diagnosis, Manifestations, Treatment

Reumathology is a very difficult matter. Profesor Holt explain it very well and make it esay. Thank you so much

By hassomi h. on 24. April 2023 for Rheuma Case: 24-year-old Woman with Pleuritic Chest Pain and Dyspnea

because its very useful lecture and the informations is very clear

Connective tissue diseases best explained with examples
By Arjit S. on 20. June 2022 for Connective Tissue Diseases

Very lucid explanation and case oriented discussion ....charts and differential diagnosis is excellent

Amazing lecture!
By Weronika W. on 24. October 2021 for Rheuma Case: 59-year-old Man with Bilateral Wrist Pain and Swelling

This is the best way of learning; To go over a case, then break down what to look for in the question stem and give reasons why an answer is incorrect. Thank you so much for these rheumatology cases.