The skin is one of the largest immunologic organs. Because of its placement between our external environment and the inside of our bodies, it can be affected by both internal and external factors. It is also a primary line of defense for our bodies, so it only makes sense that it is the site of activity of both innate and adaptive immune responses. Many skin disorders—including dermatitis, urticaria, angioedema, atopic dermatitis, and blistering disorders—are immune mediated. Most of these diseases have chronic courses and fluctuating progression in which genetic and environmental factors are implicated.
Skin disorders are important for any clinician to recognize, as they account for a large percentage of primary care and emergency department visits. Although the morphology of rashes is often difficult to differentiate, it is important to be able to do so, as treatments can vary, and these diseases can result in significant patient morbidity.
Moreover, it is of paramount importance to understand that skin disease can be a window to internal manifestations. Understanding associations between skin diseases—such as psoriasis and its link to cardiovascular disease, or bullous pemphigoid and its link to cancer—can help to guide clinical histories, physical examinations, and management.
Dr. Holt is a very effective teacher and I learned so much from him.
Loved the concise and crisp approach. Very informative lectures. Helps to get an idea about the topic in a small time
he didn´t specify where the desmosomes are exactly located
I cannot give less than five, Stephen! You merit it!