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Hemolytic Anemia: Overview – Red Blood Cell Pathology

by Carlo Raj, MD
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    Here, we’ll take a look at normocytic anemia and under normocytic, this time, it’s hemolytic anemia. What does that mean to you? It means that the bone marrow is now compensating, the bone marrow is trying to now compensate for the increased destruction of that RBC. So therefore, you call this increased reticulocytosis. Clinically, we refer to this being reticulocyte production index. The magic number then you’ll have to memorize is greater than 3%. Now, that would be in two categories here. And the reason that we have two categories with hemolytic anemia is because your RBC can be destroyed – Well, there’s a problem within the cell itself. So we will first go through intrinsic defects, but ladies and gentlemen, this is not going to picture – Or the picture that you’re going to get here is not the clinical picture, it’s just the pathogenesis of the disease. So what you’re paying attention to as you go through each one of these intrinsic and extrinsic differentials well, is the destruction of RBC taking place within the blood vessel, hence intravascular, or is it destruction of the RBC, hemolysis, taking place outside of the blood vessel primarily at the spleen and that would be extravascular, is that clear? So the way that this is divide into intrinsic and extrinsic doesn’t mean that it’s only intravascular or extravascular. I will sound like a broken record over and over again until this point gets hammered home, so without further ado, let’s get into our issues here. We’ll walk through membrane defects. These membrane defects include hereditary spherocytosis, elliptocytosis, and PNH. Next, under intrinsic, remember this would mean that the RBC itself, there’s a pathology inside the cell itself intrinsically. But what I wish to point out to you is, for example,...

    About the Lecture

    The lecture Hemolytic Anemia: Overview – Red Blood Cell Pathology by Carlo Raj, MD is from the course Hemolytic Anemia – Red Blood Cell Pathology (RBC). It contains the following chapters:

    • Overview of Hemolytic Anemias
    • Classification of Hemolytic Anemias
    • Extravascular Hemolysis
    • Intravascular Hemolysis
    • Clinical Features of Hemolytic Anemias

    Included Quiz Questions

    1. Hereditary spherocytosis
    2. Paroxysmal nocturnal hemoglobinuria
    3. Immune hemolytic anemia
    4. G6PD deficiency
    5. Hemoglobin C disease
    1. Beta thalassemia
    2. Hemoglobin C disease
    3. Pyruvate kinase deficiency
    4. Microangiopathic hemolytic anemia
    5. Sickle cell disease
    1. Malaria
    2. Hemolytic uremic syndrome
    3. None of these
    4. Thrombotic thrombocytopenic purpura
    5. Disseminated intravascular coagulation
    1. Pigment gallstones
    2. Cholesterol gallstones
    3. Methemoglobinuria
    4. Methemoglobinemia
    5. Hemoglobinuria
    1. Hemoglobinuria
    2. Pigment gallstones
    3. Methemoglobinuria
    4. Methemoglobinemia
    5. Cholesterol gallstones
    1. 120 days
    2. 60 days
    3. 180 days
    4. 160 days
    5. 80 days
    1. Unconjugated bilirubin
    2. Conjugated bilirubin
    3. Direct bilirubin
    4. Biliverdin
    5. Albumin
    1. LDH
    2. Unconjugated bilirubin
    3. Biliverdin
    4. Hemoglobinuria
    5. Conjugated bilirubin
    1. Decreased amount of free haptoglobin in intravascular hemolysis
    2. Decreased amount of free haptoglobin in extravascular hemolysis
    3. Increased amount of free haptoglobin in intravascular hemolysis
    4. Decreased amount of LDH in intravascular hemolysis
    5. Increased amount of free haptoglobin in extravascular hemolysis

    Author of lecture Hemolytic Anemia: Overview – Red Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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    thorough but succinct
    By david r. on 22. April 2017 for Hemolytic Anemia: Overview – Red Blood Cell Pathology

    clear, concise, unencumbered, helpful, good and thank you very much