So what then happens
to your RBC?
It gets spiculated.
In other words, your RBC looks like it has
little needle projections from the RBC.
So you definitely know
that the RBC is misshapen.
And most likely,
something to do with the decreased
production of ATP because you’re stuck at?
Well, you’re stuck at
And whenever you have a misshapen RBC,
where does it go for destruction?
Hereditary spherocytosis, hereditary
elliptocytosis, sickle cell.
All of them are going to go
to the spleen, resulting in?
Now, this is a child.
Whenever you have an enzyme deficiency,
you’re born with a disorder.
Serum methemoglobin is elevated.
NADH is inadequate.
Almost, well, most common
error in glycolysis.
However, in terms of
a disease though,
it’s quite rare, but make sure
that you know in greater detail
all of the different points that we made
here about pyruvate kinase deficiency.
What are you going to find?
This RBC is going to
take on bizarre shape.
And this bizarre shape is
then known as an echinocyte,
most likely due to as we said,
inadequate amounts of ATP,
having some type of influence in a negative
manner on the sodium potassium pump
in which you end up finding here
on a peripheral blood smear
are these weird spiculated
type of echinocytes.