Warm Autoimmune Hemolytic Anemia (WAIHA): Clinical Features

by Carlo Raj, MD

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    00:00 Warm type autoimmune hemolytic anemia. Clinical features.

    00:02 Signs and symptoms of anemia. What does that mean? Especially hemolytic.

    00:06 Sure. Fatigue and tiredness, anemia. In addition, what else are you gonna find with warm? What kind of hemolysis? Extravascular. So therefore jaundice this and maybe pigment stones.

    00:18 What kind of test? Direct Coomb's test. What is it going to identify? Good.

    00:23 An antibody bound to an RBC. That complex.

    00:28 What's this called that you use to bring about agglutination? Coomb's reagent. Here it is.

    00:33 The anti-IgG immunoglobulin. What temperature might you wanna use this at? At least 37 degree Celcius. Why? Warm.

    00:42 If the cells agglutinate, this indicates the presence of IgG coating the RBC membrane.

    00:48 Do you see how easy it is once you lay down the foundation? So everything that we do here, absolute clinical significance.

    00:53 But, you know, we have to have a discussion first so that all these comes to light.

    About the Lecture

    The lecture Warm Autoimmune Hemolytic Anemia (WAIHA): Clinical Features by Carlo Raj, MD is from the course Hemolytic Anemia – Red Blood Cell Pathology (RBC).

    Included Quiz Questions

    1. Hereditary spherocytosis
    2. Plasmacytoma
    3. Thalassemia
    4. Methemoglobinemia
    5. G6PD deficiency
    1. 37°C (98.6°F)
    2. 29°C (84.2°F)
    3. 30°C (86.0°F)
    4. 34°C (93.2°F)
    5. 35°C (95.0°F)
    1. Patients may present with pigmented gallstones.
    2. Patients may present with low platelets.
    3. Patients may present with fatigue.
    4. Patients may present with jaundice.
    5. Patients may present with a low hematocrit.

    Author of lecture Warm Autoimmune Hemolytic Anemia (WAIHA): Clinical Features

     Carlo Raj, MD

    Carlo Raj, MD

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