Warm type autoimmune hemolytic anemia. Clinical features.
Signs and symptoms of anemia. What does that mean? Especially hemolytic.
Sure. Fatigue and tiredness, anemia. In addition, what else are you gonna find with warm?
What kind of hemolysis? Extravascular. So therefore jaundice this and maybe pigment stones.
What kind of test? Direct Coomb's test. What is it going to identify? Good.
An antibody bound to an RBC. That complex.
What's this called that you use to bring about agglutination? Coomb's reagent. Here it is.
The anti-IgG immunoglobulin. What temperature might you wanna use this at?
At least 37 degree Celcius. Why? Warm.
If the cells agglutinate, this indicates the presence of IgG coating the RBC membrane.
Do you see how easy it is once you lay down the foundation?
So everything that we do here, absolute clinical significance.
But, you know, we have to have a discussion first so that all these comes to light.