Warm Autoimmune Hemolytic Anemia (WAIHA): Etiology

00:00 We'll talk about warm first. This is the one that is clinical significance.

00:05 Most cases are idiopathic.

00:08 However there's some important, important associations: SLE, CLL and drugs.

00:13 Take a look at these diseases. SLE is no joke.

00:17 Autoimmune destruction, malar rash, maybe SLE in this kidney damage, heart damage, all kinds of issues.

00:24 What about CLL? One of the most common leukemias that we have in our society is chronic lymphocytic leukemia.

00:33 Occurs in older patients and this is the patient that has thousands or hundreds of thousands of WBCs.

00:41 Massive leukemia taking place, right, in this patient. These are no joke type of diseases.

00:46 So, these patients who may have anemia often times will have the warm type of autoimmune hemolytic anemia.

00:55 Would you please tell me one more time what kind of immunoglobulin you're looking for in warm? Or is it "warm"? Good. IgG. We will in this lecture series go through it in great detail.

01:07 Penicillin and how methyldopa is going to then cause warm type autoimmune hemolytic anemia.

01:14 That is important. That at this point I wish to introduce and at some point by the time we're done with the lecture series, you need to make sure that you walk away having this permanently memorized in your head.

01:25 You'll see why. You'll see why.