Quickly walk through trait and disease. Let's set this out for you.
This is still hemoglobin electrophoresis. On top, well, take a look at the following.
What is normal hemoglobin A? A whopping 97%. It's dropped down to 52%.
But you still have hemoglobin A. Take a look at hemoglobin S. It's at 45%.
So you tell me, which type of sickle pattern? Good. Sickle cell trait. One S.
So, it causes spontaneous sickling in peripheral blood.
And then it's still all normocytic hemolytic.
In the bottom picture, oh my goodness, no hemoglobin A.
Most of it is in the form of hemoglobin S. This is? Good.
Sickle cell disease homozygous. No hemoglobin A.
This is dangerous. Right? Really, really dangerous.
The spleen will be damaged. Hydroxyurea is what you're thinking about.
Because what does it do? It increases fetal hemoglobin. Fetal hemoglobin.
And that's what you wanna do in this condition because in sickle cell disease you have no hemoglobin A.
Maybe bone marrow transplantation if necessary because of reticulocytosis
and at some point maybe parvovirus B19 kicks in. Fluid. Fluid. Fluid.
Analgesics. All part of your treatment regimen overall for sickle cell disease.