Genomics: Mapping and Sequencing Genomes

by Georgina Cornwall, PhD

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    In these next two lectures, we will be embarking on the study of genomics, which is the study of what the genome does. What does it code for? Before we can really think about what the parts do, we need to map the genome and sequence the genome. In this first lecture, we will learn to distinguish between genetic and physical maps as well as describe the process of DNA sequencing and finally you will be able to characterize two different methods for sequencing genomes, the clone-by-clone method versus the shotgun method. Let us begin by thinking about genetic versus physical maps. Previously we have examined genetic mapping by looking at recombination frequencies and predicting the relative distance of genes. How far genes are apart on a chromosome? This is okay, but it does not give us a very close map. Physical mapping allows us to find the actual physical location of genes on the chromosomes like all the way down such a granular level. We know precisely at what letter a gene begins. Much like we would have a map if you were trying to go to a strange place, you have a map with a fairly broad spectrum and we are going to increase resolution. You are looking at google maps say and you will look at the whole state and you decide that you want to go to Denver and so you can see Denver relative to where you are. And you drive into Denver and you want to get a little bit more granular. We zoom in further and zoom in further and eventually you are down there on downtown Denver and you are looking for a specific restaurant. We have a very fine resolution map now showing you specifically where you are and where the...

    About the Lecture

    The lecture Genomics: Mapping and Sequencing Genomes by Georgina Cornwall, PhD is from the course Genomics. It contains the following chapters:

    • Restriction Mapping
    • Cytological Maps
    • Sequence Tagged Sites
    • The Sanger Sequencing
    • Sequencing Larger Genomes

    Author of lecture Genomics: Mapping and Sequencing Genomes

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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