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Gene Mapping

by Georgina Cornwall, PhD
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    So now that we know that Mendel's factors are on chromosomes and we know about chromosomal theory, let us start to explore how we understand where things are on those chromosomes. In this lecture, we will be exploring genetic mapping. By the end of the lecture, you should be able to describe the nature of linkage groups as well as differentiate between linked and unlinked genes. In addition, you will be able to calculate distances by frequency of recombination. First it is really important for us to recall what recombination is if you remember meiosis I. We had crossing over during prophase or synapsis. To review that process, we have a set of alleles here, we will look at A and B. The F1 generation ends up being a heterozygote as we have seen previously. If we look at meiosis in our F1 cross produced the F2 gametes, we see if there is no crossing over then all we end up with is the parental gametes. However, if there is a crossing over event during prophase I. After meiosis II, we end up with some recombinant gametes. So parenteral gametes looks just like the parental types and those there had a crossing over event or synapses, will be the recombinant chromosomes. Those will go on to form the next generation. So really important to understand what recombinant chromosomes are so that we can get into gene mapping. Now each chromosome is a linkage group. All the genes that are on one chromosome are linked together in that group. If we have recombination, then we will see they become unlinked and so we can use those linkage groups to establish mapped distances. And I will show you how shortly. First of all, we know crossing over and synapses allow genetic recombination...

    About the Lecture

    The lecture Gene Mapping by Georgina Cornwall, PhD is from the course Understanding Genetics. It contains the following chapters:

    • Recombination of Chromosomes
    • Genetic Mapping
    • How to Create a Genetic Map
    • How to Avoid Missed Double Crossovers
    • The Usage of Physical Maps

    Author of lecture Gene Mapping

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD


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