Gene Expression

by Georgina Cornwall, PhD

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    In this next sequence of lectures, we will be digging into gene expression and regulation of gene expression. What better place to start than by giving you an overview and introducing you to the genetic code? By the end of this lecture, you should be able to distinguish between transcription and translation as well as discuss the one gene one polypeptide hypothesis as well as list the roles of RNA in gene expression and describe what the genetic code is. Let us move into looking at the central dogma for gene expression. Important information comes from DNA and flows through RNA and eventually to protein. A short way to say this really is that we will take DNA and we will transcribe the message into messenger RNA and then we will translate that message into proteins or polypeptides. I have a little analogy here that sort of helps with why we do at this way, but the DNA let us say is the laptop and it is best to keep your laptop in the office, not the kitchen. I generally go to my laptop in my office and I will print out a copy of my recipe so that I don't spill stuff all over my laptop. I can use that recipe and I can translate it into some delicious food. The messenger RNA is okay. That is the copy. It can get messy. We don't though want to damage the DNA. Messenger RNA helps keep your computer clean, helps keep the original copy clean. DNA to RNA to protein works out great, but then we learned about the enzyme reverse transcriptase, which actually can make a copy of RNA and go back to DNA so that sort of puts a little bit of a hole in the central dogma,...

    About the Lecture

    The lecture Gene Expression by Georgina Cornwall, PhD is from the course Genetics. It contains the following chapters:

    • One Gene One Polypeptide Hypothesis
    • A Closer Look on Transcription and Translation
    • The Gene Expression in Prokaryotes and Eukaryotes
    • The Different Types of RNA
    • How to Translate the Genetic Code

    Author of lecture Gene Expression

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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