Gene Regulation: Eukaryotes & Other Mechanisms

by Georgina Cornwall, PhD

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    Welcome back. Let us move on to take a look at regulation of gene expression in eukaryotic cells. By the end of this lecture, you should be able to describe the multiple levels of regulation that are possible in eukaryotes as well as diagram components of the transcription complex and discuss how DNA packing can impact gene expression as well as explain some other mechanisms of regulation. Let us begin by looking at the potential levels of regulation in eukaryotes because eukaryotic cells have a nucleus. We have separation of transcription and translation. We also have the production of messenger RNA so on and so forth. There is a lot more possibility at many levels. First of all, we have how DNA is packed in the nucleus. Is it available? So the chromatin can be modified in a number of ways that we'll discuss shortly. We have our DNA and the process of transcription naturally can have lots of different regulatory mechanisms. We will spend quite a bit of time there and then we take our RNA and that primary transcript needs to be modified to remove axons and put on a five prime cap and a poly A tail. RNA processing provides us with RNA. All of that stuff can be regulated. Once we have that primary or that immature messenger RNA it can be transported into the cytosol where it will have a number of different options. It could be degraded or it could be translated and we get a polypeptide and if everything is in place there, then the polypeptide will then go on to be modified after translation and folded and change a little bit to finally form an active protein and then that protein could be modified by being broken down and we have some...

    About the Lecture

    The lecture Gene Regulation: Eukaryotes & Other Mechanisms by Georgina Cornwall, PhD is from the course Gene Regulation. It contains the following chapters:

    • The Levels of Eukaryotic Gene Expression
    • A Closer Look on Transcriptional Control
    • The Impact of Chromatin on Transcription
    • RNA Interference
    • Alternative Splicing
    • RNA Editing
    • Other Mechanisms of Eukaryotic Gene Regulation

    Author of lecture Gene Regulation: Eukaryotes & Other Mechanisms

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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