Chromosome Theory & Sex Linkage

by Georgina Cornwall, PhD

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    Previously we have been examining Mendel series of inheritance, but recall Mendel had no idea about chromosomes, genes or DNA and he termed these things factors. In this lecture, we will explore chromosome theory, how we understood the existence of chromosomes as well as sex linkage. By the end of the lecture, you should be able to explain the chromosomal theory of inheritance as well as describe the nature of sex linkage and discuss how chromosomes are linked to sex determination as well as evaluate the impact of X inactivation and explain exceptions to the chromosomal theory of inheritance. Let us begin by taking a look at the chromosomal theory of inheritance. Basically, it says before we get into the background that chromosomes are the basis of all genetic inheritance. Genes are located on chromosomes in short. How do we come to this explanation? Well it was about a hundred years beyond Mendel's description of factors, that Sutton and Boveri independently researched chromosomes and their movement during meiosis. They were looking at sea urchins and grasshoppers and they noticed that chromosomes were necessary for an embryo to grow. If they removed them, they didn't work and that you could actually observe those chromosomes pairing and shuffling on the metaphase plate. So there's evidence that in physical evidence of chromosomes segregating and independent assortment, each set of chromosomes assorting independently of other sex. So there is sufficient evidence linking Mendel's factors to chromosomes. The next piece of the puzzle is to determine that this is really what is going on. It was a little bit sketchy in the beginning, people really didn't believe that that is what it happened and it took about ten years for the idea to sink in. And it was culminated with the findings of Thomas Hunt...

    About the Lecture

    The lecture Chromosome Theory & Sex Linkage by Georgina Cornwall, PhD is from the course Understanding Genetics. It contains the following chapters:

    • Linking Mendel and Chromosomes
    • Sex Chromosomes
    • Genetic Disorders That Are Sex Linked
    • Exceptions to Chromosome Theory
    • Epigenetic Factors

    Author of lecture Chromosome Theory & Sex Linkage

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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