The inflammatory response following tissue injury plays important roles in both normal and pathological healing. Immediately after injury, the innate immune system is activated, setting in motion a local inflammatory response that includes the recruitment of inflammatory cells from the circulation. This rapid response begins with the degranulation of platelets that arrive at the site as well as the injury-induced degranulation of resident mast cells. Local immune cells, including resident macrophages, are activated by proinflammatory mediators released in response to injury. The hypoxic environment of the wound also promotes inflammation, as hypoxia stimulates numerous cell types, including macrophages, to produce mediators important to inflammation.
Wound-healing is occasionally classified as either primary healing or secondary healing. Uncomplicated healing of a noninfected, well-approximated wound would be primary healing, of which surgical wounds are the best example. If the wound-healing course is disrupted by infection, dehiscence, hypoxia, or immune dysfunction, the secondary healing stage begins. During secondary healing, granulation tissue formation and epithelization over the new tissue take place. This latter type of wound are more susceptible to infections and poor healing.
Learnt so much, the explanations are clear and understandable. The lecturer's explanations was easy to follow
I really enjoy Dr Raj’s delivery of the course content ; I will happily listen to more of his lectures
Great teacher Dr Raj. Thank you a lot! Worth it
This course is very helpful to learn about the cell and it's pathology.