Domina Conceptos Médicos

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Meningitis

La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis es la inflamación de las meninges Meninges The brain and the spinal cord are enveloped by 3 overlapping layers of connective tissue called the meninges. The layers are, from the most external layer to the most internal layer, the dura mater, arachnoid mater, and pia mater. Between these layers are 3 potential spaces called the epidural, subdural, and subarachnoid spaces. Meninges: Anatomy, las membranas protectoras del cerebro y la médula espinal. Las causas de la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis son variadas, siendo las más comunes las infecciones bacterianas o virales. La presentación clásica de la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis es una tríada de fiebre, estado mental alterado y rigidez nucal. El diagnóstico de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis se basa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum criterios clínicos mediante un examen neurológico completo. El análisis del líquido cefalorraquídeo (LCR) es una herramienta de diagnóstico importante, ya que es difícil identificar clínicamente la causa exacta. El tratamiento de la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis incluye antibióticos inmediatos de amplio espectro y terapia de soporte para prevenir complicaciones. El tratamiento específico depende de la etiología de la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis. El retraso en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el tratamiento puede provocar defectos neurológicos permanentes y la muerte.

Last updated: Dec 26, 2025

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Descripción General

Definición

La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis es la inflamación de las membranas protectoras del cerebro y la médula espinal, denominadas colectivamente meninges Meninges The brain and the spinal cord are enveloped by 3 overlapping layers of connective tissue called the meninges. The layers are, from the most external layer to the most internal layer, the dura mater, arachnoid mater, and pia mater. Between these layers are 3 potential spaces called the epidural, subdural, and subarachnoid spaces. Meninges: Anatomy, que comúnmente es causada por una infección aguda.

Epidemiología

  • Se produjo una disminución significativa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la frecuencia después de la introducción de vacunas infantiles de rutina contra Haemophilus influenzae Haemophilus Influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through viii. Haemophilus y Pneumococcus.
  • Desde 2010, la incidencia máxima de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana pasó de niños < 5 años a adultos.
  • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis meningocócica se observa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum alojamientos llenos de gente.
  • La incidencia es mayor en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria países en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum desarrollo debido a la falta de acceso a medidas preventivas.
  • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis viral alcanza su punto máximo a principios del otoño y el verano.
  • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis puede ocurrir a cualquier edad y afecta a ambos sexos por igual.

Etiología

La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis puede ser de origen infeccioso (más común) o no infeccioso. La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis infecciosa puede ser adquirida en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la comunidad o en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el hospital.

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis infecciosa

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana:

  • La causa más común de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana es el Streptococcus Streptococcus Streptococcus is one of the two medically important genera of gram-positive cocci, the other being Staphylococcus. Streptococci are identified as different species on blood agar on the basis of their hemolytic pattern and sensitivity to optochin and bacitracin. There are many pathogenic species of streptococci, including S. pyogenes, S. agalactiae, S. pneumoniae, and the viridans streptococci. Streptococcus pneumoniae.
  • La frecuencia relativa de aparición varía según el grupo de edad:
    • Neonatos: Escherichia coli Escherichia coli The gram-negative bacterium Escherichia coli is a key component of the human gut microbiota. Most strains of E. coli are avirulent, but occasionally they escape the GI tract, infecting the urinary tract and other sites. Less common strains of E. coli are able to cause disease within the GI tract, most commonly presenting as abdominal pain and diarrhea. Escherichia coli, Listeria Listeria Listeria spp. are motile, flagellated, gram-positive, facultative intracellular bacilli. The major pathogenic species is Listeria monocytogenes. Listeria are part of the normal gastrointestinal flora of domestic mammals and poultry and are transmitted to humans through the ingestion of contaminated food, especially unpasteurized dairy products. Listeria Monocytogenes/Listeriosis monocytogenes, estreptococos del grupo B
    • Lactantes y niños: Neisseria meningitidis Neisseria meningitidis A species of gram-negative, aerobic bacteria. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis. It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being a, b, c, y, and w-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Neisseria, Streptococcus Streptococcus Streptococcus is one of the two medically important genera of gram-positive cocci, the other being Staphylococcus. Streptococci are identified as different species on blood agar on the basis of their hemolytic pattern and sensitivity to optochin and bacitracin. There are many pathogenic species of streptococci, including S. pyogenes, S. agalactiae, S. pneumoniae, and the viridans streptococci. Streptococcus pneumoniae
    • Adultos: S. pneumoniae, N. meningitidis N. meningitidis A species of gram-negative, aerobic bacteria. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis. It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being a, b, c, y, and w-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Neisseria (Meningococcus), L. monocytogenes L. monocytogenes A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion. Listeria Monocytogenes/Listeriosis
  • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana adquirida en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la comunidad es causada principalmente por 5 organismos:
    • S. pneumoniae (50%)
    • N. meningitidis N. meningitidis A species of gram-negative, aerobic bacteria. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis. It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being a, b, c, y, and w-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Neisseria (15%)
    • Estreptococos del grupo B (15%)
    • L. monocytogenes L. monocytogenes A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion. Listeria Monocytogenes/Listeriosis (10%)
    • H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus (10%)
  • Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis tuberculosa:
    • Causada por Mycobacterium tuberculosis Mycobacterium tuberculosis Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex bacteria. The bacteria usually attack the lungs but can also damage other parts of the body. Approximately 30% of people around the world are infected with this pathogen, with the majority harboring a latent infection. Tuberculosis spreads through the air when a person with active pulmonary infection coughs or sneezes. Tuberculosis
    • Prevaleciente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria países en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum desarrollo
    • Las condiciones predisponentes son:
      • Antecedentes de exposición previa a la tuberculosis Tuberculosis Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex bacteria. The bacteria usually attack the lungs but can also damage other parts of the body. Approximately 30% of people around the world are infected with this pathogen, with the majority harboring a latent infection. Tuberculosis spreads through the air when a person with active pulmonary infection coughs or sneezes. Tuberculosis.
      • SIDA
      • Edad joven (niños)

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis viral:

  • Enterovirus Enterovirus A genus of the family picornaviridae whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated ‘human enterovirus’. Coxsackievirus:
    • Coxsackievirus Coxsackievirus Coxsackievirus is a member of a family of viruses called Picornaviridae and the genus Enterovirus. Coxsackieviruses are single-stranded, positive-sense RNA viruses, and are divided into coxsackie group A and B viruses. Both groups of viruses cause upper respiratory infections, rashes, aseptic meningitis, or encephalitis. Coxsackievirus
    • Ecovirus
    • Enterovirus Enterovirus A genus of the family picornaviridae whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated ‘human enterovirus’. Coxsackievirus humano
  • HSV-2
  • Virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology transmitidos por artrópodos
  • VIH
  • Paperas

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis fúngica:

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis parasitaria:

  • Angiostrongylus cantonensis
  • Gnathostoma spinigerum
  • Acanthamoeba spp.
  • Naegleria fowleri
  • Taenia Taenia Taenia belong to the Cestoda class of helminths. Humans are infected with these tapeworms by eating undercooked beef (T. saginata) or pork (T. solium and T. asiatica). Taeniasis is often asymptomatic, but the ingestion of larvae can cause abdominal discomfort, nausea, and constipation or diarrhea. Taenia/Taeniasis solium
  • Strongyloides stercoralis Strongyloides stercoralis A species of parasitic nematode widely distributed in tropical and subtropical countries. The females and their larvae inhabit the mucosa of the intestinal tract, where they cause ulceration and diarrhea. Strongyloidiasis

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis no infecciosa

  • Lupus eritematoso sistémico (LES)
  • Malignidad
  • Sarcoidosis Sarcoidosis Sarcoidosis is a multisystem inflammatory disease that causes noncaseating granulomas. The exact etiology is unknown. Sarcoidosis usually affects the lungs and thoracic lymph nodes, but it can also affect almost every system in the body, including the skin, heart, and eyes, most commonly. Sarcoidosis
  • Antiinflamatorios no esteroideos (AINEs)
  • Inmunoglobulinas intravenosas (IV)
  • Enfermedad de Behçet

Factores de riesgo

  • Individuos no vacunados o aquellos que se han saltado las vacunas.
  • Niños < 5 años
  • Individuos inmunocomprometidos con afecciones como SIDA, diabetes Diabetes Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and dysfunction of the regulation of glucose metabolism by insulin. Type 1 DM is diagnosed mostly in children and young adults as the result of autoimmune destruction of β cells in the pancreas and the resulting lack of insulin. Type 2 DM has a significant association with obesity and is characterized by insulin resistance. Diabetes Mellitus, LES
  • Medicamentos inmunosupresores
  • Embarazo
  • Los LOS Neisseria brotes ocurren comúnmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum entornos de alojamiento comunitario.
  • Neumococos:
    • Otras infecciones neumocócicas: neumonía, sinusitis Sinusitis Sinusitis refers to inflammation of the mucosal lining of the paranasal sinuses. The condition usually occurs concurrently with inflammation of the nasal mucosa (rhinitis), a condition known as rhinosinusitis. Acute sinusitis is due to an upper respiratory infection caused by a viral, bacterial, or fungal agent. Sinusitis, otitis media
    • Esplenectomía, asplenia Asplenia Asplenia is the absence of splenic tissue or function and can stem from several factors ranging from congenital to iatrogenic. There is a distinction between anatomic asplenia, which is due to the surgical removal of the spleen, and functional asplenia, which is due to a condition that leads to splenic atrophy, infarct, congestion, or infiltrative disease. Asplenia
    • Hipogammaglobulinemia
    • Deficiencia de complemento
  • N. meningitidis N. meningitidis A species of gram-negative, aerobic bacteria. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis. It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being a, b, c, y, and w-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Neisseria:
    • Deficiencia de complemento
    • Serotipo B
  • L. monocytogenes L. monocytogenes A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion. Listeria Monocytogenes/Listeriosis:
    • Neonatos < 1 mes
    • Mujeres embarazadas
    • Individuos > 60 años
    • Individuos inmunodeprimidos
Imagen 3D de un grupo de diplococos gramnegativos Neisseria meningitides

Imagen tridimensional (3D) de un grupo de Neisseria meningitidis diplocócicas Gram-negativas

Imagen: “A 3D image of a group of diplococcal, Gram-negative, Neisseria meningitidis, bacteria” por Centers for Disease Control and Prevention. Licencia: Dominio Público

Fisiopatología

La inoculación directa del agente infeccioso en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las meninges Meninges The brain and the spinal cord are enveloped by 3 overlapping layers of connective tissue called the meninges. The layers are, from the most external layer to the most internal layer, the dura mater, arachnoid mater, and pia mater. Between these layers are 3 potential spaces called the epidural, subdural, and subarachnoid spaces. Meninges: Anatomy es rara en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis. Por lo general, la infección en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un sitio adyacente o remoto se propaga al AL Amyloidosis cerebro.

Inicio

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis aguda:

  • Etiología: predominantemente bacteriana o viral
  • Los LOS Neisseria síntomas se desarrollan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum unas pocas horas o en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un día.

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis crónica:

  • Etiología: bacteriana, viral, parasitaria, fúngica o no infecciosa
  • Los LOS Neisseria síntomas persisten durante > 4 semanas
  • Al AL Amyloidosis realizar una historia clínica, se deben hacer preguntas sobre viajes recientes, estado inmunológico y exposición a animales.

Patogenia de la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis infecciosa

  • El 1er paso suele ser la colonización de la mucosa.
  • Sitios de colonización:
    • Piel
    • Nasofaringe
    • Tracto respiratorio
    • Tracto gastrointestinal
    • Tracto genitourinario
  • Los LOS Neisseria mecanismos de unión a la mucosa varían según el organismo:
    • N. meningitidis N. meningitidis A species of gram-negative, aerobic bacteria. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis. It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being a, b, c, y, and w-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Neisseria: pili Pili Filamentous or elongated proteinaceous structures which extend from the cell surface in gram-negative bacteria that contain certain types of conjugative plasmid. These pili are the organs associated with genetic transfer and have essential roles in conjugation. Normally, only one or a few pili occur on a given donor cell. This preferred use of ‘pili’ refers to the sexual appendage, to be distinguished from bacterial fimbriae, also known as common pili, which are usually concerned with adhesion. Salmonella tipo 4
    • S. pneumoniae: receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors del factor activador de plaquetas, laminina, receptores poliméricos de inmunoglobulina
  • La secreción de proteasa inmunoglobulina A ( IgA IgA Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory iga is the main immunoglobulin in secretions. Immunoglobulins: Types and Functions) por patógenos inactiva la IgA IgA Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory iga is the main immunoglobulin in secretions. Immunoglobulins: Types and Functions de la mucosa y también ayuda a la unión epitelial.
  • El organismo invade la submucosa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el sitio de colonización y altera las defensas del huésped. La cápsula es un importante factor de virulencia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum este proceso.
  • Los LOS Neisseria patógenos virales generalmente se multiplican en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria ganglios linfáticos regionales antes de invadir el torrente sanguíneo.
  • La invasión del torrente sanguíneo y la diseminación hematógena al AL Amyloidosis sistema nervioso central (SNC) es la vía más común:
    • La cápsula de polisacáridos de los LOS Neisseria principales patógenos inhibe la unión del complemento y la fagocitosis.
    • La cápsula es el principal factor de supervivencia intravascular.
  • Otras vías de acceso al AL Amyloidosis SNC:
    • Transmisión neuronal retrógrada a través de nervios olfatorios o periféricos
    • Propagación contigua directa (debido a otitis, sinusitis Sinusitis Sinusitis refers to inflammation of the mucosal lining of the paranasal sinuses. The condition usually occurs concurrently with inflammation of the nasal mucosa (rhinitis), a condition known as rhinosinusitis. Acute sinusitis is due to an upper respiratory infection caused by a viral, bacterial, or fungal agent. Sinusitis)
    • Inoculación directa (raro)
    • Transmisión vertical en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum recién nacidos (desde la madre)
  • El organismo se siembra en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las meninges Meninges The brain and the spinal cord are enveloped by 3 overlapping layers of connective tissue called the meninges. The layers are, from the most external layer to the most internal layer, the dura mater, arachnoid mater, and pia mater. Between these layers are 3 potential spaces called the epidural, subdural, and subarachnoid spaces. Meninges: Anatomy.
  • Las defensas del cuerpo actúan contra el patógeno para inducir la inflamación, provocando una cascada de eventos, incluido el edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema de las meninges Meninges The brain and the spinal cord are enveloped by 3 overlapping layers of connective tissue called the meninges. The layers are, from the most external layer to the most internal layer, the dura mater, arachnoid mater, and pia mater. Between these layers are 3 potential spaces called the epidural, subdural, and subarachnoid spaces. Meninges: Anatomy y el parénquima cerebral.
  • El edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema parenquimatoso aumenta la presión intracraneal, lo que empeora los LOS Neisseria síntomas.

Presentación Clínica

Adultos

  • La tríada clásica de síntomas:
    1. Alteración del estado mental (puntuación en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la escala de coma Coma Coma is defined as a deep state of unarousable unresponsiveness, characterized by a score of 3 points on the GCS. A comatose state can be caused by a multitude of conditions, making the precise epidemiology and prognosis of coma difficult to determine. Coma de Glasgow, < 14)
    2. Fiebre > 38℃
    3. Rigidez de nuca
  • Cefalea intensa
  • Letargo y somnolencia
  • Náusea y vómito
  • Fotofobia
  • Afasia
  • Hemiparesia o monoparesia
  • Convulsiones
  • Ataxia Ataxia Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or peripheral nerve diseases. Motor ataxia may be associated with cerebellar diseases; cerebral cortex diseases; thalamic diseases; basal ganglia diseases; injury to the red nucleus; and other conditions. Ataxia-telangiectasia
  • Parálisis de los LOS Neisseria pares craneales
  • Nistagmo
  • Erupción
  • Papiledema (inflamación del disco óptico)
  • Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis por L. monocytogenes L. monocytogenes A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion. Listeria Monocytogenes/Listeriosis:
    • Mayor tendencia a tener convulsiones.
    • Defectos neurológicos focales al AL Amyloidosis comienzo de la infección.
  • Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis por N. meningitidis N. meningitidis A species of gram-negative, aerobic bacteria. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis. It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being a, b, c, y, and w-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Neisseria:
    • Manifestaciones cutáneas: petequias, púrpura palpable
    • Artritis
Síntomas de la meningitis

Presentación clínica de la meningitis

Imagen: “Main symptoms of Meningitis” por Mikael Häggström. Licencia: Dominio Público

Recién nacidos

  • Fiebre alta
  • Irritabilidad (llanto constante)
  • Somnolencia excesiva
  • Dificultad para despertar
  • Letargo
  • Mala alimentación
  • Vómito
  • Abultamiento en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la fontanela anterior
  • Cuerpo y cuello rígidos

Diagnóstico

Historia clínica

  • Aguda:
    • Enfermedad respiratoria anterior
    • Otitis/ sinusitis Sinusitis Sinusitis refers to inflammation of the mucosal lining of the paranasal sinuses. The condition usually occurs concurrently with inflammation of the nasal mucosa (rhinitis), a condition known as rhinosinusitis. Acute sinusitis is due to an upper respiratory infection caused by a viral, bacterial, or fungal agent. Sinusitis
    • Inmunodeficiencia/VIH
    • Inicio agudo con desarrollo rápido de síntomas (a menudo < 24 horas)
  • Crónica:
    • Viajes recientes
    • Residencia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum ciertas áreas endémicas (e.g., coccidioidomicosis)
    • Exposición a animales
    • Tuberculosis Tuberculosis Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex bacteria. The bacteria usually attack the lungs but can also damage other parts of the body. Approximately 30% of people around the world are infected with this pathogen, with the majority harboring a latent infection. Tuberculosis spreads through the air when a person with active pulmonary infection coughs or sneezes. Tuberculosis o prueba cutánea de tuberculina positiva
    • Sarcoidosis Sarcoidosis Sarcoidosis is a multisystem inflammatory disease that causes noncaseating granulomas. The exact etiology is unknown. Sarcoidosis usually affects the lungs and thoracic lymph nodes, but it can also affect almost every system in the body, including the skin, heart, and eyes, most commonly. Sarcoidosis

Examen físico

  • Fiebre
  • Los LOS Neisseria pacientes parecen enfermos.
  • Signos de irritación meníngea (baja sensibilidad para meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis aguda):
    • Signo de Kerning:
      • El paciente se coloca en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum decúbito supino o se sienta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum una silla.
      • La cadera y las rodillas se flexionan a 90 grados y se intenta extender la rodilla.
      • La maniobra provoca dolor Dolor Inflammation en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el cuello o la espalda.
    • Rigidez nucal:
      • El paciente se coloca en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum posición supina.
      • El tórax del paciente se sostiene con una mano mientras que la otra se mantiene debajo del occipucio.
      • El mentón se mueve hacia el esternón.
      • La contracción refleja del músculo del cuello evita que la barbilla del paciente toque el tórax.
    • Signo de Brudzinski:
      • El paciente se coloca en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum posición supina.
      • La flexión del cuello provoca la flexión involuntaria de la cadera y las rodillas.
  • Reflejo de Cushing:
    • Aumento de la presión del pulso, bradicardia y respiraciones irregulares
    • Indicativo de aumento de la presión intracraneal
  • Papiledema
  • Parálisis del músculo abducens (6to nervio)

Análisis de laboratorio

  • Hemograma
    • Recuento elevado de leucocitos
    • El diagnóstico diferencial puede ayudar a determinar la etiología:
      • Proliferación de neutrófilos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana
      • Aumento de linfocitos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis viral o fúngica
  • Hemocultivo: para identificar la causa de la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis y probar la sensibilidad a los LOS Neisseria antibióticos
  • Panel metabólico completo:
    • Compare la glucosa sérica con los LOS Neisseria niveles de glucosa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum LCR.
    • Evaluar alteraciones metabólicas.
    • Evaluar la disfunción de órganos.
  • Prueba de VIH: Prueba para el estado inmunológico si no hay antecedentes de otras afecciones inmunocomprometidas.
  • Perfil de coagulación (tiempo de protrombina, tiempo parcial de tromboplastina) previo a la punción lumbar:
    • Consumo crónico de alcohol
    • Enfermedad crónica del hígado
    • Sospecha de coagulación intravascular diseminada (CID)

Análisis del LCR

  • La punción lumbar se realiza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum todos los LOS Neisseria pacientes con sospecha de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis a menos que esté contraindicada, como por ejemplo, con aumento de la presión intracraneal o sospecha de una lesión tipo masa.
  • El análisis del LCR establece un diagnóstico definitivo y ayuda a proporcionar el tratamiento adecuado. El LCR se analiza para:
    • Presión de apertura
    • Recuento de leucocitos
    • Recuento diferencial de leucocitos
    • Niveles de glucosa
    • Proteína
    • Eritrocitos
    • Cultivo y sensibilidad

Imagenología

La imagenología no es necesaria para el diagnóstico, pero por lo general está indicadas antes de realizar una punción lumbar si existe preocupación acerca de la presión intracraneal alta y para detectar complicaciones.

  • Se puede realizar una RC o TC.
  • Suele indicarse en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum:
    • Estado inmunocomprometido
    • Antecedentes de enfermedad neurológica (lesión/accidente cerebrovascular/infección focal)
    • Convulsión dentro de 1 semana de la presentación
    • Papiledema
    • Conciencia alterada
    • Déficit neurológico focal: pupila dilatada, no reactiva/parálisis de la mirada/derivación de brazos o piernas
    • Para detectar complicaciones:
      • Hidrocefalia
      • Infarto cerebral
      • Absceso cerebral
      • Empiema subdural
      • Trombosis del seno venoso
Irritación meníngea evidente en la RM con contraste

Irritación meníngea evidente en la RM con contraste

Imagen: “Damaged Meninges” por National Institutes of Health (NIH). Licencia: Dominio Público

Tratamiento y Prevención

Tratamiento

El tratamiento se basa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el tipo de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis. La atención de soporte es común para la mayoría de los LOS Neisseria pacientes. Los LOS Neisseria antibióticos de amplio espectro generalmente se administran como una medida inmediata mientras se determina la causa.

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana:

  • Los LOS Neisseria antibióticos no deben retrasarse mientras se esperan los LOS Neisseria resultados de la TC o la punción lumbar.
  • Inicialmente, se administran antibióticos de amplio espectro.
  • Posteriormente, se ajustan los LOS Neisseria antibióticos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum función del cultivo y la sensibilidad:
    • S. pneumoniae: vancomicina + ceftriaxona
    • N. meningitidis N. meningitidis A species of gram-negative, aerobic bacteria. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis. It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being a, b, c, y, and w-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Neisseria: cefalosporina de tercera generación; penicilina G o ampicilina si es susceptible
    • H. influenzae H. influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Haemophilus: cefalosporina de tercera generación; penicilina G o ampicilina si es susceptible
    • L. monocytogenes L. monocytogenes A species of gram-positive, rod-shaped bacteria widely distributed in nature. It has been isolated from sewage, soil, silage, and from feces of healthy animals and man. Infection with this bacterium leads to encephalitis, meningitis, endocarditis, and abortion. Listeria Monocytogenes/Listeriosis: ampicilina o penicilina G + gentamicina
    • Bacilos Gram-negativos (generalmente nosocomiales): cefalosporina de tercera generación
  • La administración IV se utiliza para lograr la máxima eficacia.
  • La penetración de la barrera hematoencefálica se ve VE Ventilation: Mechanics of Breathing facilitada por la inflamación meníngea activa.
  • Se considera la administración intratecal de antibióticos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes que no responden a los LOS Neisseria antibióticos IV o en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis nosocomial.
  • La duración depende de la respuesta del paciente y del patógeno.
  • Administración de esteroides:
    • Los LOS Neisseria corticosteroides, especialmente la dexametasona, se usan como tratamiento adyuvante para la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis bacteriana.
    • Disminuye la mortalidad
    • Disminuye la tasa de complicaciones neurológicas (e.g., pérdida de la audición)
  • Tratamiento de soporte:
    • Administración de fluidos IV
    • Reposo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cama
    • Analgésicos
    • Antipiréticos
    • Anticonvulsivos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el cuidado de las convulsiones
    • Administración de inmunoglobulinas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes inmunodeficientes

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis viral:

La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis viral suele ser autolimitada y solo requiere tratamiento de soporte. La terapia antiviral Antiviral Antivirals for Hepatitis B está indicada solo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum casos seleccionados y/o severos.

  • Tratamiento de soporte:
    • Administración de fluidos IV
    • Reposo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cama
    • Analgésicos
    • Antipiréticos
    • Anticonvulsivos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el cuidado de las convulsiones
    • Administración de inmunoglobulinas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes inmunodeficientes
  • Indicaciones de la terapia antiviral Antiviral Antivirals for Hepatitis B:
    • Pacientes con VIH
    • Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis por herpes simple: aciclovir
    • Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis por citomegalovirus: ganciclovir Ganciclovir An acyclovir analog that is a potent inhibitor of the herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from aids-associated cytomegalovirus infections. Antivirals for Herpes Virus, foscarnet Foscarnet An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. Antivirals for Herpes Virus
    • Casos asociados a encefalitis

Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis fúngica:

  • El tipo más común es la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis criptocócica.
  • Los LOS Neisseria medicamentos antimicóticos administrados son:
    • Amfotericina B
    • Flucitosina
    • Fluconazol
    • Itraconazol
  • El aumento de la presión intracraneal es una complicación común de la meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis fúngica y se trata mediante:
    • Punciones lumbares regulares para drenar el exceso de líquido.
    • Colocación de un drenaje lumbar

Otros tipos de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis:

  • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis tuberculosa se trata con terapia antituberculosa:
    • Isoniazida, rifampicina, pirazinamida, etambutol, estreptomicina
    • La duración recomendada del tratamiento es de 9–12 meses.
  • Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis parasitaria:
    • Antimicrobianos: amfotericina B, miconazol, rifampicina, miltefosina
    • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis parasitaria es fatal y el tratamiento inmediato es esencial.
    • Los LOS Neisseria fármacos se administran en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum dosis altas y algunos se administran por vía intratecal.
  • Meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis no infecciosa:
    • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis alérgica o autoinmune se trata con corticoides.
    • La meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis debida al AL Amyloidosis cáncer se controla mediante el tratamiento de la afección subyacente.

Pronóstico

  • La mortalidad aumenta con la edad:
    • 18–34 años: la letalidad es del 8,9%.
    • > 65 años: La letalidad es del 22,7%.
  • Las complicaciones neurológicas (pérdida de audición, deterioro intelectual, déficits focales) afectan hasta al AL Amyloidosis 28% de los LOS Neisseria pacientes.

Prevención

Las vacunas pueden proteger contra ciertos tipos de meningitis Meningitis Meningitis is inflammation of the meninges, the protective membranes of the brain, and spinal cord. The causes of meningitis are varied, with the most common being bacterial or viral infection. The classic presentation of meningitis is a triad of fever, altered mental status, and nuchal rigidity. Meningitis:

  • Vacuna contra Haemophilus influenzae Haemophilus Influenzae A species of Haemophilus found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through viii. Haemophilus tipo B (Hib)
  • Vacuna antineumocócica conjugada
  • Vacuna meningocócica

Diagnóstico Diferencial

  • Accidente cerebrovascular: daño al AL Amyloidosis cerebro debido a la interrupción de la irrigación: el accidente cerebrovascular se presenta con defectos neurológicos, visión borrosa, dificultad para hablar y parestesia. El accidente cerebrovascular se diagnostica mediante la historia clínica, el examen neurológico e imagenología. El tratamiento depende del tipo de accidente cerebrovascular.
  • Absceso cerebral: acumulación de pus en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum respuesta a una infección o trauma: el absceso cerebral se presenta con fiebre, cefalea, convulsiones, náuseas y vómitos. Se diagnostica mediante la evaluación de signos y síntomas, análisis de sangre e imagenología. El tratamiento incluye terapia con antibióticos y cirugía para drenar el absceso.
  • Encefalitis: inflamación del parénquima cerebral por infección: la encefalitis se presenta con fiebre, cefalea, dolor Dolor Inflammation en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum músculos y articulaciones y fatiga. Se diagnostica mediante imágenes, análisis de LCR, pruebas de laboratorio y electroencefalografía. La encefalitis rara vez se presenta con rigidez de nuca y fotofobia. Las convulsiones son comunes. El tratamiento de apoyo, los LOS Neisseria medicamentos antiinflamatorios y los LOS Neisseria medicamentos antivirales se usan para controlar la encefalitis.
  • Empiema subdural: colección de pus entre la duramadre y la aracnoides: el empiema subdural se presenta con fiebre, cefalea, letargo, déficits neurológicos focales y convulsiones. Esta afección se diagnostica mediante imagenología, más comúnmente RM con contraste. El empiema subdural se trata quirúrgicamente y con antibióticos.
  • Delirium Delirium Delirium is a medical condition characterized by acute disturbances in attention and awareness. Symptoms may fluctuate during the course of a day and involve memory deficits and disorientation. Delirium tremens: forma grave de abstinencia de etanol que se presenta clínicamente con confusión global, agitación, alucinaciones, fiebre y diaforesis. El diagnóstico de delirium Delirium Delirium is a medical condition characterized by acute disturbances in attention and awareness. Symptoms may fluctuate during the course of a day and involve memory deficits and disorientation. Delirium tremens se realiza por medio de la historia y los LOS Neisseria signos y síntomas. El tratamiento se realiza con terapia de soporte y tiamina.
  • Hemorragia subaracnoidea: sangrado dentro del espacio subaracnoideo que ocurre espontáneamente o después de un traumatismo craneal: la hemorragia subaracnoidea se presenta con dolor Dolor Inflammation de cuello y hombro, entumecimiento en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum todo el cuerpo, convulsiones, confusión e irritabilidad, diplopía y cefalea repentina. El diagnóstico se basa en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la historia, signos y síntomas, y la imagenología y angiografía cerebral. La hemorragia subaracnoidea se trata quirúrgicamente. Se recomiendan agentes antihipertensivos.

Referencias

  1. Padda, I. S., & Parmar, M. (2024, February 28). Flucytosine. In StatPearls [Internet]. National Center for Biotechnology Information. Retrieved December 26, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK557607/
  2. Weinberg, G. F. (2025). Meningitis in Children. In MSD Manual Consumer Version. Retrieved December 26, 2025, from https://www.msdmanuals.com/home/children-s-health-issues/bacterial-infections-in-infants-and-children/meningitis-in-children
  3. Hasbun R. (2024). Pathogenesis and pathophysiology of bacterial meningitis. UpToDate. Retrieved December 26, 2025, from https://www.uptodate.com/contents/pathogenesis-and-pathophysiology-of-bacterial-meningitis
  4. Seed, S. (2024). Meningitis. WebMD. Retrieved December 26, 2025, from https://www.webmd.com/children/understanding-meningitis-basics#2-7
  5. Vasudeva, S. S. (2025). Meningitis. Medscape. Retrieved December 26, 2025, from https://emedicine.medscape.com/article/232915-overview#a3
  6. Mayo Clinic Staff. (2024). Meningitis – Symptoms and causes. Mayo Clinic. Retrieved December 26, 2025, from https://www.mayoclinic.org/diseases-conditions/meningitis/symptoms-causes/syc-20350508
  7. Lights, V. (2025). Everything You Need to Know About Meningitis. Healthline. Retrieved December 26, 2025, from https://www.healthline.com/health/meningitis
  8. Armas-Tarrillo, A., et al. (2025). Bacterial Meningitis in Adults: A Narrative Review. Salud Integral y Comunitaria, 3, 186. https://doi.org/10.62486/agsalud2025186
  9. Hasbun R. (2025). Clinical features and diagnosis of bacterial meningitis in adults. UpToDate. Retrieved December 26, 2025, from https://www.uptodate.com/contents/clinical-features-and-diagnosis-of-acute-bacterial-meningitis-in-adults

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