La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types es una afección enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la que losLOSNeisseria individuos tienen niveles bajos de hemoglobina (HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange), que puede deberse a varias causas. La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and TypesvaVAVentilation: Mechanics of Breathing acompañada de un número disminuido de eritrocitos y puede manifestarse con fatiga, dificultad para respirar, palidez y debilidad. LosLOSNeisseria subtipos se clasifican por el tamaño de losLOSNeisseria eritrocitos, la cronicidad y la etiología. La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types puede producirse por pérdida de sangre, por la disminución enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la producción de eritrocitos, como enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el déficit de hierro, o por el aumento de la destrucción de eritrocitos, como enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la hemólisis. El tratamiento está dirigido a mejorar losLOSNeisseria niveles de HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange y a tratar las afecciones subyacentes.
La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types es una deficiencia cuantitativa de HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange, el componente transportador de oxígeno de losLOSNeisseria eritrocitos. La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types se observa cuando losLOSNeisseria niveles de HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange son aproximadamente:
< 13,5 g/dL enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum hombres adultos
< 12 g/dL enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum mujeres adultas
< 11 g/dL enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum niños
LosLOSNeisseria niveles normales pueden variar enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum función del rango de referencia del laboratorio.
Epidemiología
Se encuentra enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum pacientes de todas las edades, desde lactantes hasta ancianos
Más común enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las mujeres que enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria hombres
Prevalencia:
> 20% de losLOSNeisseria individuos que tienen > 85 años de edad
La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types ferropénica leve es común enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las mujeres enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum edad reproductiva.
Las hemoglobinopatías son más frecuentes enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum determinadas etnias:
Enfermedad de células falciformes: Negros o afrodescendientes
Esferocitosis hereditaria: Ascendencia europea
Talasemia: Ascendencia mediterránea y del sudeste asiático
Repaso de anatomía y fisiología
LosLOSNeisseria eritrocitos se producen enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la médula ósea.
Células madre hematopoyéticas pluripotentes → célula madre mieloide común → proeritroblasto → eritrocito
La producción de eritrocitos es estimulada por la eritropoyetina, producida enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria riñones.
LosLOSNeisseria eritrocitos se eliminan a través del bazo: losLOSNeisseria eritrocitos senescentes, rígidos o anormales que no pueden pasar a través de las estrechas hendiduras esplénicas son retenidos y eliminados.
Etiología
La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types puede ser causada por:
Pérdida de sangre
Disminución de la producción de eritrocitos
Aumento de la destrucción de eritrocitos
Clasificación de la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types según su etiología
Tabla: Clasificación de la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types según su etiología
Etiología
Categorías
Tipos de anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types
Proliferación o diferenciación anormal de las células madre
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types por insuficiencia renal (debido a ↓ de eritropoyetina)
Síntesis defectuosa de ácido desoxirribonucleico (ADN) enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria eritroblastos
Deficiencia de vitamina B12
Deficiencia de folato
Síntesis defectuosa de HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange
Síntesis defectuosa del hemo:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types ferropénica
Intoxicación por plomo
Cadenas de globina defectuosas:
Hemoglobinopatías, incluida la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de células falciformes
Talasemias
Mecanismos desconocidos o múltiples
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types sideroblástica
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types por infecciones crónicas
Aumento de la destrucción de eritrocitos
HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange anormal
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de células falciformes
Talasemias
Deficiencias enzimáticas
Glucosa-6-fosfato deshidrogenasa
Glutatión sintetasa
Piruvato quinasa
Hexoquinasa
Trastornos de la membrana
Esferocitosis
Eliptocitosis
HemoglobinuriaHemoglobinuriaThe presence of free hemoglobin in the urine, indicating hemolysis of erythrocytes within the vascular system. After saturating the hemoglobin-binding proteins (haptoglobins), free hemoglobin begins to appear in the urine.Transfusion Reactions paroxística nocturna
Inmunomediado
Enfermedad autoinmune:
Idiopática (primaria)
Lupus eritematoso sistémico
Neoplasias malignas
Asociada a medicamentos:
Antibióticos
Antiinflamatorios no esteroideos (AINE)
Agentes anticancerígenos
Reacciones a transfusión
Traumatismos mecánicos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria eritrocitos
Púrpura trombocitopénica trombótica
Coagulación intravascular diseminada (CID)
Traumatismo cardíaco
Infecciones
MalariaMalariaMalaria is an infectious parasitic disease affecting humans and other animals. Most commonly transmitted via the bite of a female Anopheles mosquito infected with microorganisms of the Plasmodium genus. Patients present with fever, chills, myalgia, headache, and diaphoresis.Plasmodium/Malaria
Anquilostomas
Clasificación
La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types se suele clasificar enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria subtipos microcítico, normocítico o macrocítico enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum función del tamaño de losLOSNeisseria eritrocitos. El volumen corpuscular medio (VCM) refleja el tamaño de losLOSNeisseria eritrocitos y se reporta enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum un hemograma.
Clasificación de la anemia en función del VCM
Imagen por Lecturio.
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types microcítica
La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types microcíticase caracteriza por eritrocitos pequeños con un VCM bajo. Estas características suelen deberse a una disminución del contenido de HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas ExchangeenENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria eritrocitos. Las causas incluyen:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types ferropénica:
Causa más común de anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types
Las causas incluyen:
Pérdida sanguínea gastrointestinal crónica
Sangrado menstrual abundante y crónico
Malabsorción de hierro enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum enfermedades gastrointestinales crónicas (e.g., enfermedad de Crohn o celiaquía)
Insuficiencia de hierro enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la dieta
Embarazo
Talasemia
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types por enfermedades crónicas (etapas tardías)
Intoxicación por plomo
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types sideroblástica
Mnemotecnia:
Para recordar las causas de la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types microcítica, utilice la mnemotecnia “TAILS” (enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum inglés):
T – ThalassemiaThalassemiaThalassemia is a hereditary cause of microcytic hypochromic anemia and results from a deficiency in either the α or β globin chains, resulting in hemoglobinopathy. The presentation of thalassemia depends on the number of defective chains present and can range from being asymptomatic to rendering the more severely affected patients to be transfusion dependent. Thalassemia (talasemia)
A – AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types of chronic disease (anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types por enfermedad crónica)
I –IronIronA metallic element with atomic symbol fe, atomic number 26, and atomic weight 55. 85. It is an essential constituent of hemoglobins; cytochromes; and iron-binding proteins. It plays a role in cellular redox reactions and in the transport of oxygen.Trace Elements deficiency anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types (anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types ferropénica)
L – Lead poisoningLead poisoningPoisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of lead or lead compounds.Metal Poisoning (Lead, Arsenic, Iron) (intoxicación por plomo)
S – Sideroblastic anemiaSideroblastic anemiaSideroblastic anemias are a heterogeneous group of bone marrow disorders characterized by abnormal iron accumulation in the mitochondria of erythroid precursors. The accumulated iron appears as granules in a ringlike distribution around the nucleus, giving rise to the characteristic morphological feature of a ring sideroblast. Sideroblastic Anemia (anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types sideroblástica)
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types normocítica
La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Typesnormocítica tiene un VCM normal. A menudo el recuento de reticulocitosse utiliza para ayudar a limitar losLOSNeisseria diagnósticos diferenciales. (LosLOSNeisseria reticulocitos son células sanguíneas “nuevas” enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum circulación, y su nivel refleja la tasa de producción de nuevos eritrocitos). Las causas de la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types normocítica incluyen:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica:
Tendrá un recuento de reticulocitos corregido > 3%: indica que la médula ósea funciona normalmente
Causada por defectos intrínsecos de losLOSNeisseria eritrocitos:
Enfermedad de células falciformes
Deficiencia de glucosa-6-fosfato deshidrogenasa
HemoglobinuriaHemoglobinuriaThe presence of free hemoglobin in the urine, indicating hemolysis of erythrocytes within the vascular system. After saturating the hemoglobin-binding proteins (haptoglobins), free hemoglobin begins to appear in the urine.Transfusion Reactions paroxística nocturna
Esferocitosis hereditaria
Causas debidas a defectos extrínsecos:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica autoinmune (e.g., lupus eritematoso sistémico)
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica microangiopática (e.g., púrpura trombocitopenica trombótica, síndrome urémico hemolítico, CID)
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica macroangiopática (e.g., con válvulas cardíacas protésicas o estenosis aórtica)
Infecciones (e.g., malariaMalariaMalaria is an infectious parasitic disease affecting humans and other animals. Most commonly transmitted via the bite of a female Anopheles mosquito infected with microorganisms of the Plasmodium genus. Patients present with fever, chills, myalgia, headache, and diaphoresis.Plasmodium/Malaria)
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types no hemolítica:
Tendrá un recuento de reticulocitos corregido < 3%: indica que la médula ósea no está respondiendo alALAmyloidosis factor estresante, lo que lleva a una subproducción de eritrocitos
Causas:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types por enfermedades crónicas (etapas tempranas), generalmente enfermedad renal crónica
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types por insuficiencia cardíaca
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types por deficiencia endocrina (e.g., hipotiroidismo o insuficiencia suprarrenal)
DiabetesDiabetesDiabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and dysfunction of the regulation of glucose metabolism by insulin. Type 1 DM is diagnosed mostly in children and young adults as the result of autoimmune destruction of β cells in the pancreas and the resulting lack of insulin. Type 2 DM has a significant association with obesity and is characterized by insulin resistance.Diabetes Mellitus mellitus
Obesidad
Malignidad
Anemias aplásicas
Pérdida de sangre < 1 semana atrás (la médula ósea funciona correctamente, pero aún no haHAHemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis).Hemolytic Anemia tenido tiempo suficiente para recuperar la pérdida de sangre)
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types macrocítica
La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types macrocítica tiene un VCM elevado, o eritrocitos grandes. Las causas incluyen:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica (el problema está enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la médula ósea):
Déficit de vitaminas necesarias para la correcta síntesis del ADN (debido a una ingesta dietética insuficiente o a una mala absorción):
Déficit de vitamina B12
Déficit de folato
Causas raras:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de Diamond-Blackfan: aplasiaAplasiaCranial Nerve Palsies eritroide congénita que suele presentarse enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la infancia; losLOSNeisseria leucocitos y las plaquetas suelen ser normales
Aciduria orótica:enfermedad autosómica recesiva que se presenta con retrasos físicos e intelectuales enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la infancia, resultante de defectos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el metabolismo del ácido orótico
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types no megaloblástica (el problema está fuera de la médula ósea); puede deberse a:
Enfermedades hepáticas
Trastorno por consumo de alcohol
Reticulocitosis
Medicamentos (muchos)
Otras formas de clasificar la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types
Detalles importantes a la hora de considerar un diagnóstico de anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types:
Antecedentes de trastornos de la alimentación
Antecedentes de cirugía gástrica o intestinal
Antecedentes familiares de enfermedades hematológicas
Medicamentos que causan o empeoran hemorragias
Medicamentos que pueden causar anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica
Antecedentes de viajes
Dieta especial que puede conducir a un déficit de vitaminas (e.g., vegana)
Cantidad de alcohol consumido
Síntomas y hallazgos del examen físico
LosLOSNeisseria síntomas se desarrollan enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum función de la velocidad y la gravedad de la disminución de la HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange con respecto alALAmyloidosis valor inicial. La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types también suele ser asintomática y se detecta solo enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria estudios de laboratorio.
Tabla: Presentación clínica de la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types
Región del cuerpo/sistema
Síntomas
Posibles hallazgos del examen físico
General
Fatiga
Debilidad generalizada
Pérdida de apetito
Manos o pies fríos
Piernas inquietas
PicaPicaPica is an eating disorder characterized by a desire or recurrent compulsion to eat substances that are nonnutritive and not food. These compulsions and ingested substances are inappropriate for age or culture. Pica (comer sustancias no alimentarias como hielo o arcilla)
EdemaEdemaEdema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema de tobillos
Cabeza, ojos, oídos, nariz y garganta (HEENT, enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum inglés)
HematemesisHematemesisVomiting of blood that is either fresh bright red, or older ‘coffee-ground’ in character. It generally indicates bleeding of the upper gastrointestinal tract.Mallory-Weiss Syndrome (Mallory-Weiss Tear)
El proceso diagnóstico suele comenzar con la evaluación del hemograma, el VCM y el recuento de reticulocitos, que es mejor evaluar simultáneamente para empezar a limitar losLOSNeisseria diagnósticos diferenciales. Se puede obtener estudios adicionales enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum función de la presentación clínica del paciente.
Estudios serológicos
Hallazgos del hemograma:
Disminución de la HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange (componente de losLOSNeisseria eritrocitos)
Disminución del hematocrito (Hct)(relación entre el volumen de eritrocitos y el volumen de sangre, expresada enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum porcentaje)
VCM: ayuda a reducir losLOSNeisseria diagnósticos diferenciales
Pancitopenia: suele observarse enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica
Factores que elevan la HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange y pueden enmascarar la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types subyacente:
Tabaquismo
Hemoconcentración por hipovolemia
Gran altitud
Evaluación de reticulocitos:
Recuento de reticulocitos:
LosLOSNeisseria reticulocitos son eritrocitos inmaduros enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum circulación
Puede expresarse como un porcentaje de todos losLOSNeisseria eritrocitos o como un número absoluto
↑ Del recuento de reticulocitos indica:
Hemólisis
Recuperación de la hemorragia
Eliminación de una injuria enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la médula ósea (e.g., medicamento)
Reposición de nutrientes deficientes
Recuento de reticulocitos corregido:
Revela una respuesta adecuada frente a una inadecuada de la médula ósea
Cálculo: Recuento de reticulocitos × (Hct del paciente/Hct de referencia)
Estudios del hierro:
Incluye:
Hierro enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum suero
Transferrina y saturación de transferrina
Ferritina
Capacidad total de fijación del hierro
↓ Nivel de hierro corporal total → anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types ferropénica.
Pruebas de laboratorio cuando se sospecha de anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica:
Haptoglobina: ↓ con hemólisis
Lactato deshidrogenasa: ↑ con hemólisis
Bilirrubina indirecta: ↑ con hemólisis
Prueba de Coombs directa: detecta losLOSNeisseria anticuerpos adheridos a losLOSNeisseria eritrocitos, como enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la eritroblastosis fetal (debido a la incompatibilidad Rh)
Prueba de Coombs indirecta: detecta losLOSNeisseria anticuerpos contra losLOSNeisseria eritrocitos extraños, que están presentes enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica autoinmune
Otras pruebas serológicas:
Panel metabólico completo: para evaluar la función renal y hepática
Hormona estimulante de la tiroides (TSH, por sus siglas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum inglés)
Nivel de vitamina B12
Nivel de folato
Frotis de sangre periférica
Un frotis de sangre periférica puede ser útil para establecer la causa subyacente de una anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types.
Tabla: Hallazgos anormales de eritrocitos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum un frotis de sangre periférica
Anomalía
Descripción
Patología asociada
Células falciformes
Células con forma de hoz
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types falciforme
Cuerpos de Howell-Jolly
Cuerpos púrpura situados enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la periferia que representan restos nucleares de losLOSNeisseria eritrocitos
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types falciforme
AspleniaAspleniaAsplenia is the absence of splenic tissue or function and can stem from several factors ranging from congenital to iatrogenic. There is a distinction between anatomic asplenia, which is due to the surgical removal of the spleen, and functional asplenia, which is due to a condition that leads to splenic atrophy, infarct, congestion, or infiltrative disease. Asplenia
Células mordidas (degmacitos)
Eritrocitos con pérdida de porciones semicirculares
Glucosa-6-fosfato deshidrogenasa
Cuerpos de Heinz
Inclusiones rojo-rosadas dentro de losLOSNeisseria eritrocitos que representan agregados de HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange anormal
Glucosa-6-fosfato deshidrogenasa
Talasemias
Esferocitos
Células densas, pequeñas y esféricas, sin palidez central
Esferocitosis hereditaria
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica autoinmune
Esquistocitos
Fragmentos de eritrocitos de forma irregular
Debido a daños mecánicos:
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica microangiopática
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica macroangiopática
Normoblastos
Eritrocitos nucleados
Hemólisis severa
Células diana (codocitos)
Aspecto de ojo de buey (zona central de hemoglobinización)
Hemoglobinopatías:
Talasemia
Enfermedad de la HbC
Enfermedades hepáticas
AspleniaAspleniaAsplenia is the absence of splenic tissue or function and can stem from several factors ranging from congenital to iatrogenic. There is a distinction between anatomic asplenia, which is due to the surgical removal of the spleen, and functional asplenia, which is due to a condition that leads to splenic atrophy, infarct, congestion, or infiltrative disease. Asplenia
Punteado basófilo
Puntos de color azul púrpura dentro de losLOSNeisseria eritrocitos que representan precipitados ribosómicos
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types sideroblástica
Intoxicación por plomo
Talasemias
Dacriocitos (células enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum forma de lágrima)
Eritrocitos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum forma de lágrima
Debido a infiltración de la médula ósea:
Mielofibrosis
Síndrome mielodisplásico
Macroovalocitos
Eritrocitos grandes y ovalados
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica
Frotis de sangre periférica de un paciente con anemia megaloblástica: La flecha roja señala un neutrófilo hipersegmentado.
Image: “Hypersegmented neutrophil” por Paul Weisz Carrington, M.D. Licencia: Dominio Público
Frotis de sangre que muestra células falciformes (flechas rojas) y células diana (flechas azules)
Image: “Target cells” por Prof. Osaro Erhabor. Licencia: CC0
Cuerpos de Howell-Jolly (flechas rojas) en los glóbulos rojos circulantes de un individuo con infección abrumadora post-esplenectomía
Imagen: “f2-tm_6p02” por Serio B., Pezzullo L. et al. Licencia: CC BY 2.5
Frotis de sangre que muestra esferocitos
Image: “Spherocytes” por Ed Uthman. Licencia: CC BY 2.0Poiquilocitos en frotis de sangre de conejos:
Izquierda: esquistocitos (puntas de flecha oscuras) Derecha: esferocitos (puntas de flecha blancas) y esquistocitos (flechas blancas)
Image: “Poikilocytes in blood smears from rabbits” por Department of Pathology, Immunology and Microbiology, University of California Davis, Davis, CA, 95616, United States of America. Licencia: CC BY 4.0, recortado por Lecturio.
Punteado basófilo de eritrocitos (flechas)
Image: “Lead poisoning – blood film” por Herbert L. Fred, MD and Hendrik A. van Dijk. Licencia: CC BY 2.0
Cuerpos de Heinz en sangre periférica (como se observa en la deficiencia de glucosa-6-fosfato deshidrogenasa)
Pruebas adicionales basadas enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la presentación clínica
Nivel de cobre para deficiencia
Electroforesis de HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange
Electroforesis de proteínas séricas
Esofagogastroduodenoscopia y colonoscopia: para detectar hemorragia digestiva oculta, especialmente enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum > 50 años de edad
Biopsia de médula ósea:
Es importante tener enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum cuenta si otras líneas celulares son anormales
Leucopenia
Trombocitopenia
Hallazgos anormales
Sideroblastos anillados: anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types sideroblástica o intoxicación por plomo
Médula ósea hipocelular (punción de médula ósea seca): anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica
Permitir que el cuerpo reponga sus propios eritrocitos:
Suplemento de losLOSNeisseria nutrientes que faltan
Detener hemorragias patológicas.
Tratar la enfermedad subyacente.
Transfusión de eritrocitos para mantener la HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange
> 7 g/dL enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la mayoría de losLOSNeisseria pacientes
> 8 g/dL enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum pacientes con enfermedades cardiovasculares
Educar alALAmyloidosis paciente sobre el estilo de vida
Si se cree que losLOSNeisseria factores del estilo de vida contribuyen a la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types, se puede proporcionar educación alALAmyloidosis respecto:
Consumo de alcohol
Tabaquismo
Ingesta dietética adecuada y suplementos
Tratar la causa subyacente
Sustitución de nutrientes por vía oral para las carencias nutricionales:
Hierro
Vitamina B12
Folato
Tratar losLOSNeisseria problemas de malabsorción (e.g., enfermedad celíaca).
Tratar la fuente de la hemorragia si es patológica, por ejemplo:
Malignidad:
Cáncer de endometrio
Neoplasia de colonColonThe large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy, gástrica u otra gastrointestinal
Úlcera péptica
Enfermedad inflamatoria intestinal (e.g., colitisColitisInflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever.Pseudomembranous Colitis ulcerosa)
Enfermedad diverticular severa
Tratar las enfermedades crónicas subyacentes, enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la medida de lo posible (e.g., considerar la inyección de eritropoyetina para la enfermedad renal crónica).
Tratar las endocrinopatías si están presentes (e.g., levotiroxina para el hipotiroidismo).
Evaluar losLOSNeisseria beneficios y riesgos de losLOSNeisseria medicamentos a largo plazo que pueden empeorar la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types.
Comparación de los Tipos Comunes de Anemia
Anemias no hemolíticas
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types ferropénica: tipo de anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types más común enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum todo el mundo. La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types ferropénica se debe a una disminución del suministro de hierro, a un aumento de la pérdida de hierro (e.g., a través de una hemorragia digestiva desconocida) o a un aumento de la demanda de hierro (e.g., embarazo). El tratamiento consiste enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la administración de suplementos y/o el control de la enfermedad subyacente.
Talasemia: causa hereditaria de anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types microcítica e hipocrómica. La talasemia es una deficiencia de las cadenas de globina alfa (⍺) o beta (𝛽) que provoca una eritropoyesis ineficaz y hemólisis. Las presentaciones clínicas van desde losLOSNeisseria portadores asintomáticos hasta la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types grave con una esperanza de vida reducida.
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica: subgrupo de anemias macrocíticas debidas a una síntesis de ácido nucleico alterada enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema NodosumlosLOSNeisseria precursores eritroides. Esta alteración de la síntesis conduce a una producción ineficaz de eritrocitos y a hemólisis intramedular. Las causas más comunes son las deficiencias de vitamina B12 y de ácido fólico, que pueden deberse a una baja ingesta dietética, a afecciones subyacentes de malabsorción y a medicamentos. La presentación clínica incluye anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types, síntomas gastrointestinales y manifestaciones neurológicas.
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica: enfermedad rara que pone enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum peligro la vida y que se caracteriza por la pancitopenia y la hipocelularidad de la médula ósea enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum ausencia de células anormales, lo que refleja un daño enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las células madre hematopoyéticas. La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica puede ser adquirida o heredada. Se conocen múltiples causas, como el daño autoinmune a las células madre hematopoyéticas, medicamentos, sustancias químicas, radiación de todo el cuerpo, infecciones virales, enfermedades inmunológicas, embarazo, la anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de Fanconi y el síndrome de Down.
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types sideroblástica: este grupo heterogéneo de trastornos de la médula ósea se caracteriza por la acumulación anormal de hierro enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum las mitocondrias de losLOSNeisseria precursores eritroides. El hierro acumulado aparece como gránulos distribuidos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum forma de anillo alrededor del núcleo (sideroblastos enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum anillo). Las anemias sideroblásticas pueden deberse a defectos hereditarios enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la síntesis del hemo o pueden adquirirse a través del alcoholismo, intoxicación por plomo, medicamentos y deficiencias vitamínicas. LosLOSNeisseria niveles de hierro enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum suero suelen ser elevados.
Anemias hemolíticas
Las anemias hemolíticas son el resultado de la destrucción o eliminación prematura de losLOSNeisseria eritrocitos. EnENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum concreto, pueden deberse a un daño causado por un estrechamiento de la luz vascular (hemólisis intravascular) o a un aumento del aclaramiento esplénico (hemólisis extravascular). El aclaramiento esplénico puede ser el resultado de anomalías intrínsecas de losLOSNeisseria eritrocitos (e.g., membranas, enzimas o HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange anormales) o de un recubrimiento extrínseco de anticuerpos por parte del sistema inmunitario (e.g., incompatibilidad ABO).
Algunos ejemplos de anemias hemolíticas son:
Esferocitosis hereditaria: causada por una deficiencia de la proteína del citoesqueleto enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la membrana de losLOSNeisseria eritrocitos. Esta deficiencia da lugar a la pérdida de estabilidad de la membrana y a la deformabilidad de losLOSNeisseria eritrocitos, lo que provoca su forma esférica (esferocitos). Estas células están predispuestas a la degradación esplénica, lo que conduce a la hemólisis extravascular. LosLOSNeisseria hallazgos físicos incluyen ictericia y esplenomegalia, mientras que las pruebas de laboratorio son consistentes con anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica. El tratamiento definitivo de la esferocitosis hereditaria es la esplenectomía.
Deficiencia de glucosa-6-fosfato deshidrogenasa: esta anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica intravascular recesiva ligada alALAmyloidosis cromosoma X se debe a una anomalía heredada enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum la enzima glucosa-6-fosfato deshidrogenasa de losLOSNeisseria eritrocitos, que genera nicotinamida adenosina dinucleótido fosfato, que protege a losLOSNeisseria eritrocitos de las lesiones oxidativas. LosLOSNeisseria pacientes tienen hemólisis episódica cuando las células se encuentran con factores de estrés oxidativo.
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types de células falciformes:HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange hereditaria autosómica recesiva debida a una mutación puntual enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el gen de la beta-globina. La HbHbThe oxygen-carrying proteins of erythrocytes. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Gas Exchange anormal se polimeriza cuando se desoxigena, dando lugar a la deformación enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum forma de hoz de losLOSNeisseria eritrocitos. Estos eritrocitos enquistados se hemolizan con facilidad y provocan una obstrucción microvascular con isquemia de órganos asociada, crisis de dolorDolorInflammation grave y complicaciones sistémicas. Las células falciformes suelen verse enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum un frotis de sangre periférica.
AnemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica autoinmune: tipo raro de anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica que se caracteriza por la producción de autoanticuerpos dirigidos contra losLOSNeisseria eritrocitos, lo que provoca la destrucción de estas células enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum el bazo. La anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica autoinmune se clasifica como “caliente” o “fría”, dependiendo de la reactividad térmica de losLOSNeisseria autoanticuerpos. La etiología es diversa e incluye infecciones, enfermedades autoinmunes, trastornos linfoproliferativos y medicamentos.
HemoglobinuriaHemoglobinuriaThe presence of free hemoglobin in the urine, indicating hemolysis of erythrocytes within the vascular system. After saturating the hemoglobin-binding proteins (haptoglobins), free hemoglobin begins to appear in the urine.Transfusion Reactions paroxística nocturna:anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types hemolítica crónica adquirida, rara y grave, con exacerbaciones periódicas. La hemoglobinuriaHemoglobinuriaThe presence of free hemoglobin in the urine, indicating hemolysis of erythrocytes within the vascular system. After saturating the hemoglobin-binding proteins (haptoglobins), free hemoglobin begins to appear in the urine.Transfusion Reactions paroxística nocturna suele surgir luego de un diagnóstico de insuficiencia de la médula ósea/anemiaAnemiaAnemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica, pero también puede surgir de novo. El defecto subyacente es una mutación somática enENErythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins.Erythema Nodosum una célula madre hematopoyética multipotente del gen PIGA ligado alALAmyloidosis cromosoma X, seguida de una expansión clonal de las células madre mutadas. Estos eritrocitos anormales sufren principalmente hemólisis intravascular y pueden formar parte de una tríada clínica única que también incluye pancitopenia y trombosis venosa.
Aster, J.C. (2005). Red blood cell and bleeding disorders. In Kumar, V., Abbas, A.K., Fausto, N. (Eds). Robbins and Cotran Pathologic Basis of Disease, 7th ed., pp. 622–649.
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