Musculoskeletal System Development

by John McLachlan, PhD

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    Hi there. Welcome to this lecture on the development of the musculoskeletal system, in which we’ll also look at limb abnormalities for reasons that will become clear during the course of the lecture. So, what we’re going to do is to look at why bone develops in particular places, and how it acquires particular shapes. We’ll be looking at the mechanisms of bone morphogenesis. And then as we focus on the development of the limbs, we’ll look at the major kinds of limb abnormality. And we’ll see how these abnormalities arise from particular defects in the course of development. A usual place to start is right back at early stages of development with the somites. The somites are blocks of mesodermal tissue that lie on either side of the neural tube. So in these very early human embryos, we can see that the neural tube is fusing and extending towards the head and tail, and then either side of it lie the somites. These somites will contribute to the vertebrae, but also to much more in the developing system of the embryo. They’re laid down in sequence from head to tail, and cease to form when you’ve reached the final appropriate number. Here, we’re looking at these in section. You can see in the top picture that we have an open neural tube gradually fusing, and you can see the histological view of the section through the somites on either side of the midline. Gradually, what seems to be a simple block of mesoderm becomes much more complicated, and this is hard to see in the histological section. So, we can label the major parts here. There is the dermatome which will give rise to dermis of the skin, the myotome which will give rise to striated skeletal muscle, and...

    About the Lecture

    The lecture Musculoskeletal System Development by John McLachlan, PhD is from the course Embryology: Advanced. It contains the following chapters:

    • The Somite Formation
    • Forming of the Limbs
    • Outgrowth of the Limb
    • Genes that Control Limb Development
    • Development of Complex Bones
    • Major Limb Abnormalities

    Author of lecture Musculoskeletal System Development

     John McLachlan, PhD

    John McLachlan, PhD

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