Lung Development

by John McLachlan, PhD

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    Hello, and welcome to this lecture on the lungs and common abnormalities that occur during the course of lung development. So we’re going to look at how the lungs develop, and particularly important, is understanding the maturation of the lungs. Then we’ll look at the major abnormalities and clinical problems of lung development, and then we’ll know how to recognize them. Finally, that will lead us to their clinical significance. So, let’s explore the early stages of lung development. We’ve going to go back to this stage where we’re looking at a cross-transverse section through the embryo, the amniotic cavity up above and the yolk sac down below. We can see that the amniotic cavity is going to sweep around as the embryo begins to fold and rise up into the amniotic cavity. So a little later on, we can see that the foregut and the hindgut are beginning to develop, and it’s from the foregut that the lung is going to develop in its turn. We’ve marked in this one roundabout where the lung will begin to develop, as the yolk sac is beginning to diminish and form a narrow stalk. What we can see is that this is in the ventral part or the lower part of the foregut. At a slightly later stage, the embryo has completed this process of curving into a C-shape. And roundabout where the neck region is where the lung bud is formed in relation to the rest of the foregut. In this view, what we’ve done is to imagine that we’ve taken the foregut and filled it with some solid substance. We’re looking at all the different components of the foregut itself. So coming around from the neck, we can see where the oesophagus is, and then growing off eventually from that,...

    About the Lecture

    The lecture Lung Development by John McLachlan, PhD is from the course Embryology: Advanced. It contains the following chapters:

    • Development of the Lungs
    • Histological Differentiation during the Development of the Lungs
    • Development of the Lungs in a Transverse View
    • Respiratory Distress Syndrome
    • Tracheo-oesophageal Fistulas
    • VATER Syndrome
    • Lung Hypoplasia
    • Lung Agenesis

    Author of lecture Lung Development

     John McLachlan, PhD

    John McLachlan, PhD

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