Gut Development: Stomach, Midgut and Hindgut

by John McLachlan, PhD

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    Hello, and welcome to one of two lectures on the development of the gut. In this particular lecture, we’ll be looking at the development of the stomach, the midgut, and in particular, the midgut loop, and then the hindgut. Finally, we’ll look at some developmental abnormalities of these structures. So, we have to begin again with the process of folding of the embryo. Up above in the image, you can see the amniotic cavity on a little lower down the yolk sac. What will happen is that the embryo begins to fold, bending upwards into the amniotic cavity. Here we can see the midgut beginning to close off as the yolk sac contracts relative to the size of the overall embryo. And as this takes place, it will narrow to begin to form a yolk stalk. A little later, the embryo is bent in a C-shape and projecting up into the amniotic cavity, and the yolk sac is beginning to pinch off as seen in this view from the side. If we look at the same process seen in a cross-section, a transverse section, here we can see the amniotic cavity up above and the yolk sac down below. The folding and sweeping around process of the amniotic cavity is taking place in this plane as well. So the amniotic cavity gradually extending round the embryo. And what we can see here is that the yolk sac is beginning to be pinched off just underneath the body of the embryo. This is what will give rise to the gut. Looking at this a little later, the folding has continued and beginning to pinch off even more of the yolk sac to form the gut. In the image marked C, we can see that the gut is beginning to be pinched...

    About the Lecture

    The lecture Gut Development: Stomach, Midgut and Hindgut by John McLachlan, PhD is from the course Embryology: Advanced. It contains the following chapters:

    • Review of the Folding of the Embryo
    • The Return of the Midgut Loop
    • Development of the Hindgut
    • Abnormalities of the Development of the Gut

    Author of lecture Gut Development: Stomach, Midgut and Hindgut

     John McLachlan, PhD

    John McLachlan, PhD

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