Gut Development: Liver, Gall Bladder and Pancreas

by John McLachlan, PhD

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    Hello, and welcome to this lecture on the development of the gut, the second of two lectures on gut development. In this one, we’ll be looking at some structures which grow from the gut or associated closely with it. So we’ll be looking at the liver, the gall bladder, the pancreas, the spleen and we’ll also mention some abnormalities and variations that can occur around your development. To understand the gut, of course, we have to return to folding of the embryo. So in this image, we see the amniotic cavity in the upper part of the image, and the yolk sac down below that. As the embryo sweeps round, rises up into the amniotic cavity, so it does at the fore and hind end of the embryo to begin to create the fore and hindgut. The midgut remains open to the yolk sac. Here, we’ve emphasized these in green. So we can see the formation of the fore and hindgut as the folding of the embryo takes place. As the embryo is developing into a C-shape, so the gut also will begin to develop a curve running from the mouth down to the anus. At these early stages, both the mouth and the anus were closed by membranes, and these membranes will later disappear. From the foregut, developed the lungs, and that is explored in another lecture But in this case, we’re looking particularly at the liver. So this is going to develop as a bud from the foregut. Let’s look at the relationships between the tissues in transverse section, because this will be important to understanding the relationship of the liver with the mesoderm. Here in this transverse section, we see the amniotic cavity above and the yolk sac below. As the amniotic cavity sweeps round the body...

    About the Lecture

    The lecture Gut Development: Liver, Gall Bladder and Pancreas by John McLachlan, PhD is from the course Embryology: Advanced. It contains the following chapters:

    • Review of the Folding of the Embryo
    • Development of the Liver and the Gall Bladder
    • Development of the Spleen and the Stomach
    • Development of the Pancreas
    • Abnormalities of the Development of the Gut

    Author of lecture Gut Development: Liver, Gall Bladder and Pancreas

     John McLachlan, PhD

    John McLachlan, PhD

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