Otros Medicamentos Antirresortivos

Descripción General

La osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis es un trastorno esquelético causado por el deterioro del tejido óseo, que conduce a la fragilidad de los LOS Neisseria huesos. Los LOS Neisseria medicamentos antirresortivos se utilizan comúnmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el tratamiento de la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis para prevenir la progresión de la enfermedad.

Patogénesis de la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis

• Multifactorial
• Generalmente, es causada por un desequilibrio entre la resorción ósea y la formación de hueso.
• Si la resorción ósea > la formación de hueso, puede producirse osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis.
• Papel de la deficiencia de estrógenos:
  • ↑ Número de osteoclastos
  • ↓ Número de osteoblastos
  • ↑ Citocinas críticas para el reclutamiento de osteoclastos:
    • Interleucina-1 (IL-1)
    • Interleucina-6 (IL-6)
    • Factor de necrosis Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply. Ischemic Cell Damage tumoral ( TNF TNF Tumor necrosis factor (TNF) is a major cytokine, released primarily by macrophages in response to stimuli. The presence of microbial products and dead cells and injury are among the stimulating factors. This protein belongs to the TNF superfamily, a group of ligands and receptors performing functions in inflammatory response, morphogenesis, and cell proliferation. Tumor Necrosis Factor (TNF), por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) -α
    • RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone
  • ↓ Osteoprotegerina (OPG):
    • Liberada por preosteoblastos
    • Normalmente, se une al AL Amyloidosis RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone y actúa como supresor endógeno de la función de los LOS Neisseria osteoclastos.

Medicamentos antirresortivos

• Los LOS Neisseria bifosfonatos se utilizan como terapia de 1ra línea.
• Otros medicamentos antirresortivos incluyen:
  • Moduladores selectivos de los LOS Neisseria receptores de estrógeno (p. ej., raloxifeno)
  • Inhibidor de RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone ( denosumab Denosumab A humanized monoclonal antibody and an inhibitor of the rank ligand, which regulates osteoclast differentiation and bone remodeling. It is used as a bone density conservation agent in the treatment of osteoporosis. Other Antiresorptive Drugs)
  • Terapia estrogénica para la menopausia (pacientes posmenopáusicas seleccionadas)
  • Calcitonina (usada rara vez debido a su eficacia limitada)

Hormonas

Medicamentos de esta clase

• Teriparatida
• Abaloparatida
• Calcitonina

Farmacodinamia

Teriparatida:

• Hormona PTH recombinante → se une a los LOS Neisseria receptores PTH tipo 1
• Mecanismo de acción:
  • ↑ Absorción de calcio en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria intestinos y en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria riñones (reabsorción)
  • ↑ Número y supervivencia de osteoblastos → ↑ función de osteoblastos → formación de hueso
  • ↑ Expresión del RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone → ↑ formación y función de los LOS Neisseria osteoclastos → resorción ósea
• El efecto de la PTH depende del patrón de dosificación:
  • Intermitente, dosis baja: efecto anabólico (formación de hueso > resorción)
  • Exposición continua: efecto catabólico (resorción ósea> formación)
  • El razonamiento subyacente no está del todo claro.
• Efecto fisiológico:
  • ↑ Densidad mineral ósea
  • ↑ Fuerza ósea

Abaloparatida:

• Análogo sintético del péptido relacionado con la hormona paratiroidea → se une a los LOS Neisseria receptores de la hormona paratiroidea tipo 1
• Mecanismo de acción:
  • ↑ Actividad osteoblástica → ↑ formación ósea
  • La administración intermitente produce un efecto anabólico (formación ósea > resorción ósea)
  • La exposición continua puede volverse catabólica (resorción ósea > formación ósea)
• Efecto fisiológico:
  • ↑ Densidad mineral ósea (especialmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la columna vertebral)
  • ↑ Resistencia ósea
  • ↓ Fracturas vertebrales y no vertebrales

Calcitonina:

• Normalmente, es producida por las células C en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la glándula tiroides.
• Calcitonina exógena:
  • Más comúnmente del salmón
  • Más potente que la calcitonina humana:
    • ↑ Afinidad por los LOS Neisseria receptores de calcitonina
    • Menor tasa de aclaramiento
• Mecanismo de acción:
  • ↓ Reabsorción de calcio y fosfato en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el riñón.
  • Se opone a la acción de la PTH
  • Inhibe la actividad de los LOS Neisseria osteoclastos → ↓ resorción ósea
  • Permite un ↑ neto en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la mineralización ósea (indirectamente)
• Efecto fisiológico: ↑ densidad ósea

Farmacocinética

Teriparatida:

• Absorción: ↑ biodisponibilidad cuando se administra por vía subcutánea.
• Metabolismo: hepático a través de proteólisis.
• Excreción: orina

Abaloparatida:

• Absorción: ↑ biodisponibilidad al AL Amyloidosis administrarse por vía subcutánea
• Metabolismo: Degradado principalmente por enzimas proteolíticas inespecíficas
• Excreción: orina
• Vida media: aproximadamente 1 hora después de la inyección subcutánea

Calcitonina:

• Absorción:
  • Rápida
  • Presentaciones:
    • Subcutánea
    • Intramuscular
    • Intranasal
• Metabolismo:
  • Degradada en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum:
    • Riñones (principalmente)
    • Sangre
    • Tejidos
  • Metabolitos inactivos
• Excreción: orina

Indicaciones

• La teriparatida se usa para el tratamiento de la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis.
  • Para hombres y mujeres posmenopáusicas que:
    • Tienen una enfermedad grave
    • Tienen ↑ riesgo de fractura
    • No pueden tolerar la terapia con bifosfonatos.
    • Fallan otras terapias
  • No es una terapia de primera línea debido a:
    • ↑ Costo
    • Problemas de seguridad a largo plazo
  • Se debe tener una ingesta adecuada de calcio y vitamina D
  • Beneficio: ↓ riesgo de fracturas (notablemente, tanto de cadera como vertebrales)
• Abaloparatida: se utiliza para el tratamiento de la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis.
  • Para mujeres posmenopáusicas que:
    • Presentan ↑ riesgo de fractura o son intolerantes o han fracasado con otras terapias
    • Beneficio: ↓ riesgo de fracturas vertebrales y no vertebrales
  • Para hombres con osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis que:
    • Presentan ↑ riesgo de fractura o son intolerantes o han fracasado con otras terapias
    • Beneficio: aumenta la densidad mineral ósea (no se ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia establecido la reducción del riesgo de fractura en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum hombres)
  • No es un tratamiento de primera línea debido a su alto costo, problemas de seguridad a largo plazo y no se recomienda su uso por más de 2 años.
  • Debe tener una ingesta adecuada de calcio y vitamina D.
• Calcitonina:
  • Osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis:
    • Para mujeres posmenopáusicas (> 5 años después de la menopausia)
    • No es tan eficaz como otras terapias; por lo tanto, no es comúnmente usada
    • Beneficio: ↓ riesgo de fracturas vertebrales
  • Hipercalcemia:
    • Conduce a una rápida ↓ de los LOS Neisseria niveles de calcio sérico
    • Terapia complementaria
  • Enfermedad de Paget (si es intolerante o no responde a otras terapias)

Efectos secundarios

Teriparatida y abaloparatida:

• Cefalea
• Náuseas
• Hipercalcemia
• Hipercalciuria
• Empeoramiento de la calcifilaxis
• Hipotensión
• Taquicardia
• Anafilaxia y angioedema Angioedema Angioedema is a localized, self-limited (but potentially life-threatening), nonpitting, asymmetrical edema occurring in the deep layers of the skin and mucosal tissue. The common underlying pathophysiology involves inflammatory mediators triggering significant vasodilation and increased capillary permeability. Angioedema
• ↑ Riesgo de osteosarcoma Osteosarcoma Osteosarcoma is a primary malignant tumor of the bone characterized by the production of osteoid or immature bone by the tumor cells. The disease is most common in children and young adults and most frequently affects growth plates of the long bones, although it can involve any bone. Osteosarcoma

Calcitonina:

• Rinitis
• Epistaxis Epistaxis Bleeding from the nose. Granulomatosis with Polyangiitis
• Enrojecimiento
• Mareo
• ↑ Riesgo de cáncer
• Hipocalcemia
• Reacciones alérgicas:
  • Broncoespasmo
  • Anafilaxia
  • Erupción

Contraindicaciones

Teriparatida:

• Hiperparatiroidismo
• Otras afecciones hipercalcémicas, que incluyen:
  • Enfermedad granulomatosa crónica
  • Hipercalcemia maligna
• Personas con ↑ riesgo de osteosarcoma Osteosarcoma Osteosarcoma is a primary malignant tumor of the bone characterized by the production of osteoid or immature bone by the tumor cells. The disease is most common in children and young adults and most frequently affects growth plates of the long bones, although it can involve any bone. Osteosarcoma

Abaloparatida:

• Antecedentes de hipersensibilidad sistémica a la abaloparatida o a cualquier componente de la formulación del producto

Calcitonina:

• Hipocalcemia
• Se debe realizar una prueba cutánea en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum personas que puedan tener hipersensibilidad.

Moduladores Selectivos del Receptor de Estrógenos

Medicamentos de esta clase

• Raloxifeno
• Tamoxifeno (no se usa generalmente para el tratamiento de la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis)

Farmacodinamia

• Los LOS Neisseria moduladores selectivos del receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de estrógenos se unen selectivamente a los LOS Neisseria receptores de estrógeno.
• El raloxifeno puede actuar como agonista o antagonista de estrógenos (según el tejido):
  • Agonista:
    • Hueso
    • Hígado
    • Sistema cardiovascular
  • Antagonista:
    • Mamas
    • Útero
• En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el hueso:
  • ↓ Actividad de osteoclastos
  • ↓ Número de osteoclastos
  • ↓ IL-6 y TNF-α
  • Efecto fisiológico:
    • ↓ Resorción ósea
    • ↑ Densidad ósea

Farmacocinética

La farmacocinética del raloxifeno es la siguiente:

• Absorción:
  • Oral
  • Rápida
• Distribución:
  • Altamente unido a la albúmina
  • No se une a la globulina fijadora de hormonas sexuales ( SHBG SHBG A glycoprotein migrating as a beta-globulin. Its molecular weight, 52, 000 or 95, 000-115, 000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as androgen-binding protein. They differ by their sites of synthesis and post-translational oligosaccharide modifications. Gonadal Hormones, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés)
• Metabolismo:
  • Metabolismo de 1er paso en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el hígado
  • Sufre glucuronidación
• Excreción: principalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las heces.

Indicaciones

• Tratamiento y prevención de la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres posmenopáusicas:
  • Se prefiere el raloxifeno al AL Amyloidosis tamoxifeno.
  • Puede ser elegido para mujeres con:
    • ↑ Riesgo de cáncer de mama
    • Intolerancia a los LOS Neisseria bifosfonatos
  • ↓ Riesgo de fracturas vertebrales
  • No es eficaz en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres premenopáusicas.
• Tratamiento del cáncer de mama y reducción del riesgo (especialmente para el tamoxifeno)

Efectos secundarios

Los LOS Neisseria siguientes efectos secundarios están asociados con el uso de raloxifeno:

• Sofocamientos
• Calambres en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las piernas
• Artralgia
• Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema periférico
• ↑ Riesgo de eventos tromboembólicos:
  • Trombosis venosa profunda
  • Embolismo pulmonar
  • Accidente cerebrovascular
  • Trombosis de las venas retinianas

Contraindicaciones

• Embarazo
• Antecedentes de tromboembolismo

Inhibidores del RANKL

Medicamentos de esta clase

El denosumab Denosumab A humanized monoclonal antibody and an inhibitor of the rank ligand, which regulates osteoclast differentiation and bone remodeling. It is used as a bone density conservation agent in the treatment of osteoporosis. Other Antiresorptive Drugs es el único medicamento de la clase de medicamentos inhibidores del RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone.

Farmacodinamia

• Fisiología normal:
  • RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone (un miembro de la superfamilia TNF TNF Tumor necrosis factor (TNF) is a major cytokine, released primarily by macrophages in response to stimuli. The presence of microbial products and dead cells and injury are among the stimulating factors. This protein belongs to the TNF superfamily, a group of ligands and receptors performing functions in inflammatory response, morphogenesis, and cell proliferation. Tumor Necrosis Factor (TNF)) regula la remodelación ósea.
  • Los LOS Neisseria preosteoclastos expresan el receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors activador de los LOS Neisseria receptores del factor nuclear kappa-B (RANK, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) → activados por RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone → maduración en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum osteoclastos
• El denosumab Denosumab A humanized monoclonal antibody and an inhibitor of the rank ligand, which regulates osteoclast differentiation and bone remodeling. It is used as a bone density conservation agent in the treatment of osteoporosis. Other Antiresorptive Drugs es un anticuerpo monoclonal humano → se une al AL Amyloidosis RANKL RANKL A tumor necrosis factor receptor family member that is specific for rank ligand and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on dendritic cells where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with tnf receptor-associated factors. Paget Disease of Bone → previene la unión al AL Amyloidosis RANK
• Imita el efecto de la OPG
• Resulta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la ↓ la formación y función de los LOS Neisseria osteoclastos
  • ↓ Resorción ósea
  • ↑ Densidad ósea

Farmacocinética

• Administrado como inyección subcutánea.
• Vida media: 25‒28 días
• Lo más probable es que se someta a una depuración del sistema reticuloendotelial.

Indicaciones

• Tratamiento de la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis:
  • Una opción para mujeres posmenopáusicas y para algunos grupos de hombres, incluidos aquellos con pérdida ósea debido a:
    • Glucocorticoides
    • Inhibidores de la aromatasa
    • Terapia de privación de andrógenos
  • Se utilizan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum individuos que:
    • No pueden tolerar los LOS Neisseria bifosfonatos.
    • Están en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum ↑ riesgo de fracturas
    • Tienen deterioro renal
  • No son utilizados en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum:
    • Terapia de primera línea
    • Mujeres premenopáusicas
    • Prevención
• Indicaciones relacionadas con malignidad:
  • Metástasis óseas (para prevenir fracturas patológicas)
  • Tumor Tumor Inflammation óseo de células gigantes (para personas que no pueden someterse a una cirugía)
  • Mieloma múltiple (para prevenir fracturas patológicas)
  • Hipercalcemia maligna (refractaria a la terapia con bifosfonatos)

Efectos secundarios

• ↑ Riesgo de infecciones, incluyendo:
  • Nasofaringitis
  • Sinusitis Sinusitis Sinusitis refers to inflammation of the mucosal lining of the paranasal sinuses. The condition usually occurs concurrently with inflammation of the nasal mucosa (rhinitis), a condition known as rhinosinusitis. Acute sinusitis is due to an upper respiratory infection caused by a viral, bacterial, or fungal agent. Sinusitis
  • Otitis
  • Gastroenteritis Gastroenteritis Gastroenteritis is inflammation of the stomach and intestines, commonly caused by infections from bacteria, viruses, or parasites. Transmission may be foodborne, fecal-oral, or through animal contact. Common clinical features include abdominal pain, diarrhea, vomiting, fever, and dehydration. Gastroenteritis
  • Cistitis
• Dolor Dolor Inflammation musculoesquelético
• Metabólicos:
  • Hipercolesterolemia
  • Hipofosfatemia
  • Hipocalcemia (particularmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la enfermedad renal crónica)
• Hueso:
  • Osteonecrosis de la mandíbula.
  • Fractura atípica de fémur
  • ↑ Riesgo de fractura vertebral tras la interrupción

Contraindicaciones

• Embarazo
• Hipocalcemia

Interacciones medicamentosas

• Calcimiméticos: ↑ riesgo de hipocalcemia
• Inmunosupresores: ↑ riesgo de infección grave

Comparación de las Clases de Medicamentos Antirresortivos

La siguiente tabla compara los LOS Neisseria mecanismos de acción y los LOS Neisseria efectos secundarios de las clases de medicamentos utilizados para controlar y/o prevenir la osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis: