Neutropenia

Descripción General

Definición

La neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia es una disminución en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la cantidad de neutrófilos circulantes en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la sangre, que generalmente se define como un recuento absoluto de neutrófilos de:

• < 1 500 células/µL en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum adultos y niños > 1 año de edad:
  • Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia leve: 1 000–1 500 células/µL
  • Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia moderada: 500–1 000 células/µL
  • Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia severa: < 500 células/µL
  • Agranulocitosis: < 100–200 células/µL
• < 1 000 células/µL en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum niños de 2 semanas a 1 año de edad
• < 5 000 células/µL en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum lactantes durante sus 1ros días de vida

Neutrófilos

Los LOS Neisseria neutrófilos son los LOS Neisseria leucocitos más comunes. Los LOS Neisseria leucocitos son glóbulos blancos y son un componente importante del sistema inmunológico.

• Los LOS Neisseria neutrófilos responden rápidamente al AL Amyloidosis sitio de la infección.
• Los LOS Neisseria neutrófilos son leucocitos granulocíticos:
  • Contienen enzimas, oxidantes y proteínas, dentro de 4 tipos de gránulos, los LOS Neisseria cuales se forman durante la diferenciación de los LOS Neisseria neutrófilos:
    • Gránulos azurófilos (primarios): contienen proteínas antibacterianas como mieloperoxidasa y CAP37; funcionan principalmente dentro de los LOS Neisseria fagolisosomas
    • Gránulos específicos: contienen proteínas antibacterianas, como lactoferrina, lipocalina asociada a gelatinasa de neutrófilos, catelicidina y lisozima, y proteasas, como colagenasa
    • Gránulos de gelatinasa: contienen proteína antibacteriana, lisozima y las proteasas gelatinasa (matriz metaloproteinasa 9) y leucolisina
    • Gránulos secretores: contienen receptores transmembranales (e.g., receptores del factor de necrosis Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply. Ischemic Cell Damage tumoral y receptores de interferón-α) que se integran en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la membrana plasmática de los LOS Neisseria neutrófilos a medida que tiene lugar la exocitosis
  • Pueden producir trampas extracelulares de neutrófilos (NETs, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés):
    • Compuestas por redes de microfibras extracelulares, conformados principalmente por ácido desoxirribonucleico (ADN) de neutrófilos alterados
    • Las trampas extracelulares de neutrófilos se unen y degradan bacterias y otros patógenos
• Otros términos:
  • A menudo denominados células polimorfonucleares
  • Neutrófilos más jóvenes e inmaduros conocidos como “bandas” o “células punzantes”
• Típicamente, se reportan como un porcentaje de los LOS Neisseria leucocitos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un hemograma
• Recuento absoluto de neutrófilos:
  • La cantidad de neutrófilos (a diferencia del porcentaje de leucocitos) que circulan por µL de sangre
  • Recuento absoluto de neutrófilos = leucocitos/µL × porcentaje (neutrófilos segmentados + bandas)
  • Ejemplo:
    • Leucocitos = 5 600 células/µL; neutrófilos = 5%; bandas = 2%
    • Recuento absoluto de neutrófilos = 5 600 × 7% = 392 células/µL
• Niveles normales de recuento absoluto de neutrófilos: varían según la edad

Importancia clínica de la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia

• La correlación entre el recuento absoluto de neutrófilos y el riesgo infeccioso solo se aplica a las afecciones en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las que la reserva de neutrófilos de la médula ósea está disminuida, como la toxicidad hematológica de la quimioterapia.
• Con la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia leve no relacionada con la quimioterapia (recuento absoluto de neutrófilos, 1 000–1 500 células/µL), no hay un aumento significativo del riesgo de infección.
• Con neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia severa (recuento absoluto de neutrófilos, < 500/µL), existe un riesgo significativo de infección; la fiebre debe tratarse con hospitalización y antibióticos parenterales, incluso con pocos signos clínicos de infección.

Epidemiología

Prevalencia:

• 1%–10% en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum individuos sanos, asintomáticos
• Mayor prevalencia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum aquellos con ciertas afecciones médicas:
  • Trastornos autoinmunes: lupus eritematoso sistémico (LES), artritis reumatoide
  • Enfermedades del tejido conectivo
• Varía según etnicidad:
  • Negros: 4,5 %–10,5%
  • Blancos: 0,79%
  • Mexicanos americanos: 0,38%

La neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia puede ocurrir como una característica aislada o en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum asociación con otras anomalías hematológicas y/o defectos de la médula ósea (e.g., anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica o leucemia).

Fisiopatología

Revisión de fisiología normal

Los LOS Neisseria neutrófilos maduros son producidos por precursores en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la médula ósea.
Los LOS Neisseria neutrófilos se pueden encontrar en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum tres compartimentos:

• Médula ósea: los LOS Neisseria neutrófilos aquí se pueden clasificar como:
  • Proliferativos: en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum desarrollo
  • Almacenados: neutrófilos maduros
• Sangre: los LOS Neisseria neutrófilos aquí se pueden clasificar como:
  • Circulantes
  • Marginados: adheridos al AL Amyloidosis endotelio vascular o ubicados dentro del bazo
• Tejidos: los LOS Neisseria neutrófilos abandonan la sangre al AL Amyloidosis azar después de aproximadamente 6–10 horas para ingresar a los LOS Neisseria tejidos, donde actúan para destruir patógenos o sufrir apoptosis Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, I.e., DNA fragmentation. It is genetically-programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Ischemic Cell Damage.

Mecanismos que conducen a la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia

• Disminución de la producción/diferenciación en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la médula ósea:
  • Precursores hematopoyéticos dañados (e.g., quimioterapia, radiación, infección)
  • Granulopoyesis ineficaz (e.g., anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica)
  • Infiltración de la médula ósea (e.g., leucemia)
• Marginación:
  • Desplazamiento de los LOS Neisseria polimorfonucleares circulantes al AL Amyloidosis endotelio vascular o al AL Amyloidosis bazo
  • Ejemplo: la endotoxina puede causar marginación → ↓ neutrófilos circulantes (a veces denominada pseudoneutropenia)
• Destrucción inmune periférica mejorada:
  • Reacciones a medicamentos
  • Proceso autoinmune

Etiología

La neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia es comúnmente adquirida, a menudo después de infecciones o como efecto secundario de varios medicamentos diferentes. En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum raras ocasiones, la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia puede ser “primaria” o heredada congénitamente como parte de un síndrome menos común.

Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia adquirida: no inducida por medicamentos

• Infecciones (forma más común de neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia adquirida):
  • Virales, incluyendo:
    • Citomegalovirus (CMV)
    • Virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology del Ebstein-Barr ( EBV EBV Epstein-barr virus (EBV) is a linear, double-stranded DNA virus belonging to the herpesviridae family. This highly prevalent virus is mostly transmitted through contact with oropharyngeal secretions from an infected individual. The virus can infect epithelial cells and B lymphocytes, where it can undergo lytic replication or latency. Epstein-Barr Virus, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés)
    • Influenza Influenza Influenza viruses are members of the Orthomyxoviridae family and the causative organisms of influenza, a highly contagious febrile respiratory disease. There are 3 primary influenza viruses (A, B, and C) and various subtypes, which are classified based on their virulent surface antigens, hemagglutinin (HA) and neuraminidase (NA). Influenza typically presents with a fever, myalgia, headache, and symptoms of an upper respiratory infection. Influenza Viruses/Influenza
    • Hepatitis viral
    • Virus Virus Viruses are infectious, obligate intracellular parasites composed of a nucleic acid core surrounded by a protein capsid. Viruses can be either naked (non-enveloped) or enveloped. The classification of viruses is complex and based on many factors, including type and structure of the nucleoid and capsid, the presence of an envelope, the replication cycle, and the host range. Virology de inmunodeficiencia humana (VIH)
  • Bacterianas, incluyendo:
    • Sepsis Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by hypotension despite adequate fluid infusion, it is called septic shock. Sepsis and Septic Shock bacteriana
    • Tuberculosis Tuberculosis Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis complex bacteria. The bacteria usually attack the lungs but can also damage other parts of the body. Approximately 30% of people around the world are infected with this pathogen, with the majority harboring a latent infection. Tuberculosis spreads through the air when a person with active pulmonary infection coughs or sneezes. Tuberculosis
    • Infecciones por rickettsias
  • Parásitos:
    • Toxoplasmosis Toxoplasmosis Toxoplasmosis is an infectious disease caused by Toxoplasma gondii, an obligate intracellular protozoan parasite. Felines are the definitive host, but transmission to humans can occur through contact with cat feces or the consumption of contaminated foods. The clinical presentation and complications depend on the host’s immune status. Toxoplasma/Toxoplasmosis
    • Malaria Malaria Malaria is an infectious parasitic disease affecting humans and other animals. Most commonly transmitted via the bite of a female Anopheles mosquito infected with microorganisms of the Plasmodium genus. Patients present with fever, chills, myalgia, headache, and diaphoresis. Plasmodium/Malaria
• Neoplasias malignas hematológicas (típicamente presentan pancitopenia):
  • Leucemias
  • Otros trastornos linfoproliferativos
  • Síndrome mielodisplásico
  • Mielofibrosis
• Supresión de la médula ósea:
  • Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types aplásica
  • Radiación ionizante
  • Infiltración maligna
  • Medicamentos (ver más abajo)
• Hiperesplenismo
• Causas nutricionales:
  • Deficiencia de vitamina B₁₂ o folato ( anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica; puede verse en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el alcoholismo)
  • Deficiencia de cobre
• Proceso autoinmune y/o asociado a trastornos reumatológicos:
  • LES
  • Artritis reumatoide
  • Síndrome de Sjögren
  • Enfermedad de Crohn
  • Granulomatosis con poliangeitis
  • Reacciones transfusionales
• Activación del complemento:
  • Hemodiálisis con membranas no biocompatibles
  • Síndrome de dificultad respiratoria aguda
• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia idiopática crónica

Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia adquirida: inducida por medicamentos

Algunos medicamentos, incluidos muchos agentes de quimioterapia, producen mielosupresión predecible dependiente de la dosis. Muchos otros medicamentos están asociados con neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia aislada grave (conocida como reacción idiosincrásica a medicamentos), que generalmente ocurre dentro de los LOS Neisseria 3 meses posteriores al AL Amyloidosis inicio del medicamento.

Medicamentos asociados con mielosupresión (lista parcial, incluye muchos agentes de quimioterapia e inmunosupresores):

• Metotrexato
• Ciclofosfamida
• Cisplatino, carboplatino
• Etopósido
• Doxorrubicina
• Colchicina
• Azatioprina
• Ganciclovir Ganciclovir An acyclovir analog that is a potent inhibitor of the herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from aids-associated cytomegalovirus infections. Antivirals for Herpes Virus

Medicamentos asociados con la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia por reacción idiosincrásica a medicamentos (lista parcial, los LOS Neisseria más comunes están resaltados):

• Antibióticos: Penicilinas (especialmente penicilina G), cefalosporinas, sulfonamidas, macrólidos, vancomicina, dapsona
• Antimalaria: cloroquina, quinina
• Antifúngicos: anfotericina B, flucitosina
• Antivirales: aciclovir, oseltamivir Oseltamivir An acetamido cyclohexene that is a structural homolog of sialic acid and inhibits neuraminidase. Antivirals for Influenza, ganciclovir Ganciclovir An acyclovir analog that is a potent inhibitor of the herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from aids-associated cytomegalovirus infections. Antivirals for Herpes Virus
• Antiinflamatorios: antiinflamatorios no esteroideos (AINE), sulfasalazina, penicilamina
• Tionamidas (medicamentos para la tiroides): metimazol, propiltiouracilo
• Medicamentos cardiovasculares: ticlopidina, procainamida, propranolol Propranolol A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for myocardial infarction; arrhythmia; angina pectoris; hypertension; hyperthyroidism; migraine; pheochromocytoma; and anxiety but adverse effects instigate replacement by newer drugs. Antiadrenergic Drugs, digoxina, inhibidores de la enzima convertidora de angiotensina (IECA), hidralazina
• Diuréticos: tiazidas, acetazolamida, espironolactona
• Psicotrópicos: clozapina, fenotiazinas, antidepresivos tricíclicos
• Antiepilépticos: fenitoína, carbamazepina, ácido valproico
• Agentes anticancerosos no mielosupresores: rituximab Rituximab A murine-derived monoclonal antibody and antineoplastic agent that binds specifically to the cd20 antigen and is used in the treatment of leukemia; lymphoma and rheumatoid arthritis. Immunosuppressants, inhibidores de la tirosina cinasa

Neutropenias congénitas o primarias

La neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia se asocia con múltiples síndromes poco comunes. Ejemplos incluyen:

• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia familiar benigna (étnica)
• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia hereditaria (o congénita)
• Síndrome de Kostmann
• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia cíclica
• Síndrome de Shwachman-Diamond

Presentación Clínica

Los LOS Neisseria pacientes con neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia serán asintomáticos, presentarán infecciones o presentarán síntomas asociados con la causa subyacente de su neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia.

Infecciones

Los LOS Neisseria síntomas primarios relacionados directamente con la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia involucran infecciones. Las infecciones virales pueden causar neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia, mientras que los LOS Neisseria pacientes con neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia moderada a grave tienen más probabilidades de desarrollar una infección bacteriana o fúngica. Los LOS Neisseria pacientes con neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia pueden presentar:

• Infecciones recurrentes (e.g., otitis media recurrente)
• Infecciones oportunistas (e.g., erupción por cándida)
• Infecciones graves con neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia severa (recuento absoluto de neutrófilos < 200 células/µL):
  • Sepsis Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by hypotension despite adequate fluid infusion, it is called septic shock. Sepsis and Septic Shock
  • Infecciones gastrointestinales y pulmonares potencialmente mortales

Organismos más comunes que causan infecciones recurrentes, oportunistas y/o graves:

• Bacilos gram-negativos:
  • Escherichia coli Escherichia coli The gram-negative bacterium Escherichia coli is a key component of the human gut microbiota. Most strains of E. coli are avirulent, but occasionally they escape the GI tract, infecting the urinary tract and other sites. Less common strains of E. coli are able to cause disease within the GI tract, most commonly presenting as abdominal pain and diarrhea. Escherichia coli
  • Klebsiella Klebsiella Klebsiella are encapsulated gram-negative, lactose-fermenting bacilli. They form pink colonies on MacConkey agar due to lactose fermentation. The main virulence factor is a polysaccharide capsule. Klebsiella pneumoniae is the most important pathogenic species. Klebsiella spp.
  • Pseudomonas aeruginosa Pseudomonas aeruginosa A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. Aeruginosa is a major agent of nosocomial infection. Pseudomonas
• Cocos gram-positivos (especialmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes con catéteres permanentes):
  • Staphylococcus Staphylococcus Staphylococcus is a medically important genera of Gram-positive, aerobic cocci. These bacteria form clusters resembling grapes on culture plates. Staphylococci are ubiquitous for humans, and many strains compose the normal skin flora. Staphylococcus spp.
  • Streptococcus viridans Streptococcus viridans A large heterogeneous group of mostly alpha-hemolytic streptococci. They colonize the respiratory tract at birth and generally have a low degree of pathogenicity. This group of species includes Streptococcus mitis; Streptococcus mutans; Streptococcus oralis; Streptococcus sanguis; Streptococcus sobrinus; and the Streptococcus milleri group. The latter are often beta-hemolytic and commonly produce invasive pyogenic infections including brain and abdominal abscesses. Brain Abscess
• Cándida spp., especialmente después de que los LOS Neisseria pacientes neutropénicos reciban tratamiento con antibióticos de amplio espectro

Los LOS Neisseria hallazgos clínicos dependerán de la localización de la infección y el organismo causal y, con mayor frecuencia, pueden incluir:

• Fiebre
• Fatiga
• Linfadenopatía
• Hallazgos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la piel:
  • Erupción
  • Celulitis, úlceras y/o abscesos
  • Ictericia (puede sugerir enfermedad hepática secundaria a hepatitis viral)
• Hallazgos de otorrinolaringología:
  • Úlceras bucales recurrentes
  • Gingivitis Gingivitis Inflammation of gum tissue (gingiva) without loss of connective tissue. Chédiak-Higashi Syndrome
• Hallazgos pulmonares (si hay neumonía):
  • Tos TOS Thoracic outlet syndrome (TOS) is a broad term used for a spectrum of syndromes related to the general region of the thoracic outlet, which involves the compression or irritation of elements of the brachial plexus, subclavian artery, or subclavian vein. Thoracic Outlet Syndrome
  • Disnea
  • Matidez a la percusión
• Musculoesqueléticos:
  • Dolor Dolor Inflammation y/o inflamación de las articulaciones
  • Mialgias

Nota: los LOS Neisseria pacientes no tienen un mayor riesgo de infecciones virales o parasitarias, ya que los LOS Neisseria neutrófilos no neutralizan estas infecciones.

Otros hallazgos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria antecedentes clínicos y el examen físico

• Puede ser asintomático
• Antecedentes de medicamentos que pueden causar neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia
• Síntomas relacionados con la causa principal, por ejemplo:
  • LES:
    • Dolor Dolor Inflammation/inflamación de las articulaciones
    • Erupción
    • Hematuria Hematuria Presence of blood in the urine. Renal Cell Carcinoma
    • Dolor Dolor Inflammation pleurítico
  • Mielofibrosis:
    • Dolor Dolor Inflammation óseo
    • Fatiga y disnea debido a anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types concurrente

Diagnóstico

Estudios de laboratorio

• Hemograma con diferencial:
  • Determina la gravedad de la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia
  • Determina si la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia es aislada o está asociada con otras anomalías hematológicas (ayuda a especificar el diagnóstico diferencial); ejemplos incluyen:
    • Eosinofilia → reacciones a medicamentos/alergias o infecciones parasitarias
    • Linfocitosis → leucemias, linfomas
    • Linfopenia → inmunodeficiencia
    • Anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types megaloblástica → deficiencia de folato o vitamina B₁₂
• Frotis de sangre periférica:
  • Confirma el número reducido de neutrófilos
  • Neutrófilos hipersegmentados → deficiencia de folato o vitamina B₁₂
  • Linfocitos atípicos → causa viral
  • Anomalías compatibles con leucemias (e.g., linfocitos manchados, proyecciones similares a filamentos o gránulos azurofílicos)
• Velocidad de eritrosedimentación ( ESR ESR Soft Tissue Abscess, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) y proteína C reactiva (CRP, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés): dado que los LOS Neisseria hallazgos clásicos de infección o inflamación pueden no ser aparentes
• Otras pruebas de laboratorio a considerar según los LOS Neisseria antecedentes clínicos y los LOS Neisseria hallazgos del examen:
  • Hemocultivo y urocultivo si hay fiebre
  • Análisis de heces si el paciente tiene diarrea infecciosa
  • Pruebas de causas reumatológicas:
    • Anticuerpos antinucleares
    • Anticuerpos anti-ADN
    • Niveles de complemento
  • Detección de deficiencias nutricionales:
    • Cobre sérico
    • Niveles de folato y vitamina B₁₂
  • Detección de infección por VIH
  • Pruebas genéticas si se sospechan síndromes congénitos

Otras pruebas

Otras pruebas a considerar según la presentación clínica incluyen:

• Radiografía de tórax para evaluar si hay infección o malignidad
• Ultrasonido o tomografía computarizada (TC) del abdomen para obtener imágenes del hígado y el bazo
• Aspiración y biopsia de médula ósea si se sospecha malignidad

Tratamiento

Tratamiento general

El tratamiento depende de la causa y el grado de la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia.

• Suspender medicamentos causales.
• Reponer las deficiencias vitamínicas causales (vitamina B12, folato y/o cobre).
• Supervisar el recuento absoluto de neutrófilos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum hemogramas seriales:
  • Para la mayoría de los LOS Neisseria pacientes, la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia se debe a una infección o medicación
  • Repetir el hemograma para asegurar la resolución de la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia luego de la mejoría de la infección/discontinuación de los LOS Neisseria agentes agresores
  • Si la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia persiste, se indica un estudio adicional
• Infecciones:
  • Tratar las infecciones con los LOS Neisseria agentes apropiados
  • Profilaxis contra la infección:
    • Lavado de manos para prevenir infecciones
    • Evitar la exposición a personas enfermas
    • Cuidado dental regular Regular Insulin
• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia asociada a autoinmunidad: Considerar inmunoglobulina intravenosa y/o esteroides si la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia es severa y debido a su condición autoinmune.
• Factores estimulantes de colonias de granulocitos:
  • Estimulan naturalmente la producción de neutrófilos
  • Ejemplos: filgrastim Filgrastim A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of neutropenia, preparation and collection of blood progenitor cells, and for use in peripheral blood stem cell transplantation. Hematopoietic Growth Factors, pegfilgrastim Pegfilgrastim Hematopoietic Growth Factors
  • Indicados en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum:
    • Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia febril aguda
    • Uso profiláctico en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes de quimioterapia con riesgo de neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia
    • Niños con neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia congénita grave y/o insuficiencia de la médula ósea
    • Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia cíclica si el recuento absoluto de neutrófilos < 200 e infecciones están presentes
• Trasplante de médula ósea: puede ser curativo para niños con síndrome de Kostmann
• Indicaciones para derivación inmediata a hematología:
  • Blastos u otros hallazgos que sugieran malignidad hematológica observada en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum frotis de sangre periférica
  • Recuento absoluto de neutrófilos < 200
  • Pancitopenia

Tratamiento de la fiebre neutropénica en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes con cáncer

La fiebre neutropénica es la complicación potencialmente mortal más común de la terapia contra el cáncer.

• La terapia antibiótica empírica en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la presentación es imprescindible para mejorar los LOS Neisseria resultados y disminuir la mortalidad.
• Un organismo causal se identifica solo ⅓ de las veces y, por lo tanto, los LOS Neisseria antibióticos están destinados a tratar un amplio espectro de patógenos esperados.
• Se ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia demostrado que los LOS Neisseria antibióticos profilácticos y el apoyo del factor de crecimiento al AL Amyloidosis inicio de la neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia benefician solo a un pequeño subgrupo de pacientes con cáncer de alto riesgo que reciben quimioterapia.

Diagnóstico Diferencial de las Neutropenias Primarias

• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia familiar benigna (étnica): causa hereditaria de neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia leve a moderada, que se observa con mayor frecuencia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum personas de ascendencia africana. Estos pacientes pueden no generar leucocitosis durante la infección, pero por lo demás su presentación es normal. Generan fiebre y taquicardia durante la infección (similar a los LOS Neisseria controles), no tienen una mayor incidencia de infección y no tienen un mayor riesgo de neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia febril secundaria a la terapia mielosupresora. Las reservas de médula ósea en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum estos pacientes son normales.
• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia hereditaria/ neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia congénita: afección resultante de mutaciones en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum uno de varios genes Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. DNA Types and Structure, típicamente heredada de forma autosómica dominante y que a menudo conduce a una neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia grave. Esta afección es más común en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum lactantes y niños pequeños. Los LOS Neisseria síntomas incluyen llagas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la boca, fiebre frecuente, neumonía, infecciones de oído y llagas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el recto. Si la afección no se trata de inmediato, un niño puede comenzar a perder dientes como resultado de infecciones graves de las encías.
• Síndrome de Kostmann: causa hereditaria de neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia congénita severa (recuento absoluto de neutrófilos es a menudo < 200). Se hereda con un patrón autosómico recesivo, aunque se desconocen los LOS Neisseria genes Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. DNA Types and Structure causantes. El síndrome de Kostmann es una afección agresiva en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la que los LOS Neisseria pacientes no pueden producir neutrófilos de manera efectiva. Los LOS Neisseria pacientes suelen enfermarse gravemente y pueden requerir un trasplante de médula ósea, que es curativo.
• Neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia cíclica: causa autosómica dominante de neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia episódica tanto en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum niños como en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum adultos. Los LOS Neisseria episodios ocurren aproximadamente cada 3 semanas (rango, 12–35 días) y continúan durante 3–6 días en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un solo ciclo. Los LOS Neisseria síntomas incluyen fiebre, infecciones y úlceras. Muchos niños mejoran después de la pubertad.
• Síndrome de Shwachman-Diamond: síndrome muy raro que se presenta en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la infancia, se hereda con un patrón autosómico recesivo. El síndrome se caracteriza por insuficiencia pancreática, disostosis metafisaria (ensanchamiento en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria extremos de los LOS Neisseria huesos largos con constricción y esclerosis de la diáfisis), retraso del crecimiento y neutropenia Neutropenia Neutrophils are an important component of the immune system and play a significant role in the eradication of infections. Low numbers of circulating neutrophils, referred to as neutropenia, predispose the body to recurrent infections or sepsis, though patients can also be asymptomatic. Neutropenia con o sin anemia Anemia Anemia is a condition in which individuals have low Hb levels, which can arise from various causes. Anemia is accompanied by a reduced number of RBCs and may manifest with fatigue, shortness of breath, pallor, and weakness. Subtypes are classified by the size of RBCs, chronicity, and etiology. Anemia: Overview and Types o trombocitopenia.