Class 4 Antiarrhythmic Drugs (Calcium Channel Blockers)
Overview Calcium channel blockers (CCBs) Medications that block the L-type calcium channels (mostly found in the myocardium, vascular smooth muscles, and pancreatic β islet cells) Common uses: hypertension, angina, and supraventricular dysrhythmias Pharmacologic classes Dihydropyridine: Binds more selectively to vascular smooth muscle calcium channels (vasodilator) Can lead to reflex tachycardia Example: amlodipine Non-dihydropyridine: Affects the […]
Antimalarial Drugs
Plasmodia Life Cycle and Prophylaxis The treatment of malaria is targeted at different stages of the Plasmodium life cycle: Treatment consists of 3 steps: Malaria prophylaxis and prevention Blood Schizonticides, Tissue Schizonticides, and Gametocides Blood schizonticides Tissue schizonticides Gametocides Gametocidal + schizonticidal: Artemisinins and Antifolate Drugs Artemisinins Antifolate drugs Erythrocides and Miscellaneous Drugs Erythrocides Miscellaneous […]