Class 4 Antiarrhythmic Drugs (Calcium Channel Blockers)
Overview Calcium channel blockers (CCBs) Pharmacologic classes Physiology Pharmacology of CCB Mechanism of action Effects Absorption and excretion Indications Drug class Examples Indications Key points Dihydropyridines Nifedipine, nicardipine, amlodipine, felodipine, nimodipine Hypertension Stable angina Vasospastic angina/coronary vasospasm Cerebral vasospasm (especially nimodipine prophylaxis after subarachnoid hemorrhage) Raynaud’s phenomenon (especially amlodipine) Vasodilators; + risk of reflex tachycardia […]
Antimalarial Drugs
Plasmodia Life Cycle and Prophylaxis The treatment of malaria is targeted at different stages of the Plasmodium life cycle: Treatment consists of 3 steps: Malaria prophylaxis and prevention Blood Schizonticides, Tissue Schizonticides, and Gametocides Blood schizonticides Tissue schizonticides Gametocides Gametocidal + schizonticidal: Artemisinins and Antifolate Drugs Artemisinins Antifolate drugs Erythrocides and Miscellaneous Drugs Erythrocides Miscellaneous […]