Estrógenos y Progestinas no Anticonceptivos

Descripción General

Definiciones

• «Estrógeno» se utiliza como término genérico para cualquier agente estrogénico (estrona, estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins y estriol Estriol A hydroxylated metabolite of estradiol or estrogen that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, a large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Noncontraceptive Estrogen and Progestins); estos agentes pueden ser sintetizados por el cuerpo humano o pueden encontrarse en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum preparaciones sintéticas utilizadas para terapia médica.
• A diferencia del término estrógeno, progesterona no es un término genérico. La progesterona se refiere únicamente a la hormona sintetizada por el cuerpo lúteo. La progesterona micronizada en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum forma de píldora es químicamente idéntica a la progesterona de origen ovárico humano.
• Las progestinas son agentes progestacionales sintéticos que no son idénticas a la progesterona producida por los LOS Neisseria ovarios; algunos ejemplos son la drospirenona, el levonorgestrel Levonorgestrel A synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. Hormonal Contraceptives y la medroxiprogesterona utilizadas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria anticonceptivos orales, implantes y DIU hormonales.

Clasificación

• Estrógenos esteroideos naturales:
  • El estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins (E2) es el estrógeno más potente:
    • Producido principalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria ovarios; cantidad diminuta producida en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las glándulas suprarrenales y los LOS Neisseria testículos mediante la aromatización de la testosterona
    • Junto con la progesterona, regula el ciclo menstrual.
    • Mantiene el crecimiento mamario y uterino.
    • Mantiene el embarazo.
    • Desempeña un papel en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la homeostasis Homeostasis The processes whereby the internal environment of an organism tends to remain balanced and stable. Cell Injury and Death del calcio y tiene efectos beneficiosos sobre los LOS Neisseria huesos.
  • Estrona ( E1 E1 An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from androstenedione directly, or from testosterone via estradiol. In humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. Noncontraceptive Estrogen and Progestins):
    • Producida por el ovario
    • Producto final del metabolismo del estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins
  • Estriol Estriol A hydroxylated metabolite of estradiol or estrogen that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, a large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Noncontraceptive Estrogen and Progestins ( E3 E3 A hydroxylated metabolite of estradiol or estrogen that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, a large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Noncontraceptive Estrogen and Progestins):
    • No tiene actividad hormonal.
    • Producido en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el último trimestre del embarazo por conversión placentaria de esteroides suprarrenales fetales
    • Se relaciona con el bienestar fetal y la viabilidad placenta-feto.
• Esteroide sintético: etinilestradiol
• Estrógeno no esteroideo sintético: dietilestilbestrol; su utilización ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia sido discontinuado, pero sigue siendo histórica y clínicamente significativo para las hijas de las madres que lo utilizaron.
• Progesterona natural: llamada progesterona micronizada en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum forma de píldora
• Progestinas sintéticas:
  • Caproato de hidroxiprogesterona
  • Acetato de medroxiprogesterona
  • Derivados de la 19-nortestosterona:
    • Desogestrel Desogestrel A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. Hormonal Contraceptives
    • Noretindrona
    • Acetato de noretindrona
    • Diacetato de etinodiol
    • Levonorgestrel Levonorgestrel A synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. Hormonal Contraceptives

Estrógenos

En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el cuerpo, el estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins es oxidado a estrona, y tanto el estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins como la estrona se pueden convertir en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum estriol Estriol A hydroxylated metabolite of estradiol or estrogen that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, a large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Noncontraceptive Estrogen and Progestins. La estrona es un estrógeno biológicamente activo que se encuentra en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum medicamentos compuestos y en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum algunas preparaciones farmacéuticas que se utilizan para tratar los LOS Neisseria síntomas de la menopausia. La estrona se prepara a partir de la orina de yeguas embarazadas (estrógeno equino conjugado).

Los LOS Neisseria fitoestrógenos (isoflavonas de soja) son estrógenos derivados de plantas que se unen con menor potencia que el estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins al AL Amyloidosis receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de estrógenos y se encuentran en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum preparaciones farmacéuticas y botánicas/a base de hierbas.

Mecanismo de acción

• Estrógeno en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum plasma Plasma The residual portion of blood that is left after removal of blood cells by centrifugation without prior blood coagulation. Transfusion Products y líquido intersticial:
  • Unido a la globulina fijadora de hormonas sexuales
  • Se disocia para entrar en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las células y unirse a sus receptores.
• La hormona se une a su receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors → alteración conformacional → liberación de las proteínas estabilizadoras.
• El complejo receptor-hormona forma homodímeros → se une a una secuencia específica de nucleótidos (elementos de respuesta al AL Amyloidosis estrógeno) en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria promotores de varios genes Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. DNA Types and Structure → regulación de la transcripción.
• Los LOS Neisseria efectos indirectos de los LOS Neisseria estrógenos están mediados por acciones autocrinas y paracrinas:
  • Factores de crecimiento
  • Lípidos
  • Glucolípidos
  • Citocinas
  • Producidos por células diana en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum respuesta al AL Amyloidosis estrógeno

Efectos fisiológicos

• Efectos endometriales:
  • Desempeñan un papel importante en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el desarrollo del revestimiento endometrial.
  • La producción de estrógeno se coordina con la de progesterona durante el ciclo menstrual normal para el sangrado regular Regular Insulin y el desprendimiento del revestimiento endometrial.
  • Exposición continua → hiperplasia endometrial y sangrado uterino anormal
• Efectos metabólicos y cardiovasculares:
  • Parcialmente responsables del mantenimiento de la estructura normal de la piel y los LOS Neisseria vasos sanguíneos
  • ↓ Tasa de reabsorción ósea en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum personas con osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis
  • Efectos positivos sobre los LOS Neisseria lípidos plasmáticos: ↑ HDL y ↓ niveles de colesterol plasmático total
• Efectos sobre la coagulación sanguínea:
  • ↑ Niveles circulantes de los LOS Neisseria factores II, VII, IX y X
  • ↓ Antitrombina III
  • ↑ Niveles de plasminógeno
  • ↓ Adherencia plaquetaria
• Otros efectos:
  • Inducen la síntesis de receptores de progesterona.
  • Tienen influencias sobre el estado de ánimo y la libido.
  • Estimulan la producción de la hormona liberadora de corticotropina.
  • Facilitan la pérdida de líquido intravascular hacia el espacio extracelular → edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema.
  • Modulan el control del sistema nervioso simpático de la función del músculo liso.

Farmacocinética

• Formulaciones disponibles:
  • Oral:
    • La mayoría de los LOS Neisseria preparados utilizados son sintéticos y derivados de fuentes vegetales.
    • Los LOS Neisseria estrógenos equinos conjugados derivados de la orina de yeguas embarazadas (nombre comercial Premarin ®, tanto en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum píldoras como en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum crema vaginal) todavía se utilizan, pero eran mucho más frecuentes en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las últimas décadas.
  • Tópico:
    • Sin efectos de 1.er paso: perfil de riesgo más bajo
    • Niveles plasmáticos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum estado estacionario
    • Transdérmicos
    • Geles tópicos
    • Emulsiones
    • Lociones
  • Intravaginal:
    • Indicación: vulvovaginitis Vulvovaginitis The term vulvovaginitis is used to describe an acute inflammation of the vulva and vagina. Vulvovaginitis can be caused by several infectious and non-infectious etiologies, and results from disruption of the normal vaginal environment. Common signs and symptoms include pain, pruritus, erythema, edema, vaginal discharge and dyspareunia. Vulvovaginitis atrófica
    • Sin efecto de 1.er paso: perfil de riesgo más bajo
    • No hay necesidad de reemplazo de progesterona en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la mayoría de las mujeres.
    • Presentaciones: cremas, tabletas, anillos vaginales
• Absorción:
  • Oral:
    • Alto efecto de 1.er paso
    • Concentraciones séricas de estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins casi constantes entre las dosis
    • ↑ Producción de proteínas hepáticas
  • Transdérmica y tópica:
    • Sin efecto de 1.er paso
    • Absorción rápida y completa
  • Anillo vaginal:
    • Absorción rápida durante la 1.ra hora
    • Disminuye a una absorción estable durante los LOS Neisseria próximos 3 meses.
• Distribución:
  • El 97% del estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la sangre se une a las proteínas plasmáticas:
    • Principalmente unido a globulina fijadora de hormonas sexuales
    • Menor afinidad con la albúmina
  • ↑ Concentración en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum órganos diana
  • Estrógeno unido:
    • Relativamente no disponible para la difusión celular
    • La fracción libre es fisiológicamente activa.
• Metabolismo:
  • Enzimas hepáticas CYP3A4 CYP3A4 Class 3 Antiarrhythmic Drugs (Potassium Channel Blockers)
  • Recirculación enterohepática → convertido en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum metabolitos de estrógenos activos, incluida la estrona
• Excreción:
  • Orina
  • Bilis
• Vida media:
  • Estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins: 1‒2 horas
  • Estrona: 4–18 horas
  • Absorción extendida con las formas transdérmicas, tópicas e inyectables

Indicaciones

Los LOS Neisseria productos de estrógenos, con o sin progestina, a menudo se recetan para tratar los LOS Neisseria síntomas vasomotores y otros síntomas asociados con la menopausia. Estos productos también están indicados para mujeres más jóvenes con insuficiencia ovárica prematura.

• Insuficiencia ovárica primaria
  • Razón principal:
    • Reduce el riesgo de osteoporosis Osteoporosis Osteoporosis refers to a decrease in bone mass and density leading to an increased number of fractures. There are 2 forms of osteoporosis: primary, which is commonly postmenopausal or senile; and secondary, which is a manifestation of immobilization, underlying medical disorders, or long-term use of certain medications. Osteoporosis, enfermedades cardiovasculares y atrofia genital.
    • Mantiene la salud sexual y la calidad de vida.
    • Para las mujeres con insuficiencia ovárica primaria que también necesitan anticoncepción, además del reemplazo hormonal, se pueden utilizar anticonceptivos orales.
  • Amenorrea:
    • Las niñas con amenorrea primaria y falta de caracteres sexuales secundarios se tratan inicialmente con dosis muy bajas de estrógeno (sin progestina al AL Amyloidosis inicio) para simular una maduración puberal gradual.
    • Las mujeres con amenorrea secundaria deben recibir dosis completas de reemplazo de estrógeno (dosis más altas que las que se utilizan para los LOS Neisseria síntomas posmenopáusicos).
• Se utilizan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con progestinas para suprimir la ovulación en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum personas con:
  • Dismenorrea intratable
  • Hirsutismo
  • Amenorrea debido a la secreción excesiva de andrógenos ováricos
• Terapia hormonal para la menopausia (THM):
  • Factores a considerar:
    • Edad
    • Gravedad de los LOS Neisseria síntomas
    • Riesgos individuales de enfermedades cardiovasculares, eventos trombóticos y cáncer de mama
  • El objetivo principal es tratar los LOS Neisseria sofocos:
    • Indicación más común: síntomas moderados a severos con un impacto negativo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la calidad de vida
    • Los LOS Neisseria síntomas leves no requieren tratamiento.
  • Los LOS Neisseria objetivos secundarios son tratar:
    • Sequedad vaginal
    • Trastornos del sueño
    • Labilidad del estado de ánimo
    • Depresión
    • Dolor Dolor Inflammation articular
  • Terapia hormonal para la menopausia segura:
    • Para mujeres saludables con síntomas moderados a severos
    • Para mujeres en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria 1.ros 10 años de la menopausia o ≤ 60 años ( en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum general, no se recomienda su uso en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres ≥ 65)
    • Cuando no hay contraindicaciones
  • Regímenes de tratamiento:
    • Estrógenos sin progesterona/progestina después de la histerectomía
    • Terapia combinada de estrógenos y progestinas para mujeres con un útero intacto para prevenir la hiperplasia endometrial asociada a estrógenos y el cáncer de endometrio
  • Atrofia vulvovaginal (también llamada síndrome genitourinario de la menopausia):
    • Estrógenos vaginales en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum dosis bajas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum lugar de formas sistémicas
    • Pueden continuarse indefinidamente una vez que ha HA Hemolytic anemia (HA) is the term given to a large group of anemias that are caused by the premature destruction/hemolysis of circulating red blood cells (RBCs). Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis). Hemolytic Anemia cesado el uso de hormonas sistémicas.
• Mujeres transgénero: El estrógeno se utiliza en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con la terapia antiandrogénica.

Efectos secundarios

• Sangrado vaginal
• Mayor riesgo de cáncer de mama y de endometrio
• Sensibilidad en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum las mamas
• Hiperpigmentación de la piel
• Migrañas
• Colestasis
• Hipertensión
• Enfermedad tromboembólica:
  • IM
  • Accidente cerebrovascular
  • Trombosis venosa profunda ( DVT DVT Deep vein thrombosis (DVT) usually occurs in the deep veins of the lower extremities. The affected veins include the femoral, popliteal, iliofemoral, and pelvic veins. Proximal DVT is more likely to cause a pulmonary embolism (PE) and is generally considered more serious. Deep Vein Thrombosis, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés)

Contraindicaciones

• Cánceres de mama y endometrio
• Enfermedad de las arterias coronarias
• Sangrado vaginal sin diagnóstico
• Enfermedades hepáticas
• Trastornos tromboembólicos
• Accidente cerebrovascular o ataque isquémico transitorio
• Fumadores de tabaco mayores de 35 años

Interacciones farmacológicas

• Aumento del aclaramiento de estrógenos y otras hormonas esteroideas:
  • Medicamentos anticonvulsivantes
  • Utilice estrógenos transdérmicos para evitar el efecto de 1.er paso.
• Estrógenos que provocan un aumento de la globulina transportadora de tiroxina:
  • Disminuyen la tiroxina biodisponible.
  • Las preparaciones transdérmicas son menos ofensivas.
  • Las personas con hipotiroidismo pueden necesitar ↑ dosis de reemplazo tiroideo si también toman estrógenos.
  • Monitorice los LOS Neisseria niveles de la hormona estimulante de la tiroides (TSH, por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés).
• ↑ Niveles de estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins sérico:
  • Ingestión de alcohol
  • Enfermedad renal terminal: Es importante reducir la dosis de estrógenos.

Progesterona y Progestina

La progesterona (medicamento bioidéntico) y las progestinas (preparados sintéticos) a menudo se utilizan con estrógenos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres con síntomas menopáusicos que no se han sometido a una histerectomía.

Las mujeres posmenopáusicas sin un útero intacto no necesitan de una progestina, ya que no la progestina no presenta beneficios para la salud, además de prevenir la hiperplasia endometrial y el cáncer.

Las mujeres más jóvenes con insuficiencia ovárica primaria reciben tratamiento con estradiol Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. Noncontraceptive Estrogen and Progestins y progesterona micronizada para simular la función ovárica normal tanto como sea posible.

Clasificación

• Progesterona (producida en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el cuerpo):
  • Estimula el crecimiento del cabello.
  • Tiene propiedades antiandrogénicas.
  • Puede mejorar el estado de ánimo y el sueño.
  • No está descrito que aumente el riesgo de cáncer de mama.
• Progestinas (elaboradas sintéticamente a partir de una fuente vegetal):
  • Pueden causar hipertensión.
  • Pueden causar pérdida de cabello.
  • Algunas tienen propiedades androgénicas.
  • Pueden tener efectos secundarios sobre el estado de ánimo (e.g., ansiedad, depresión).
  • En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con estrógenos → mayor riesgo de cáncer de mama
  • En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con estrógenos → posible aumento del riesgo de demencia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres posmenopáusicas > 64

Mecanismo de acción

• Entran a la célula → se unen a los LOS Neisseria receptores de progesterona que se distribuyen entre el núcleo y el citoplasma.
• El complejo receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de progesterona forma un dímero antes de unirse al AL Amyloidosis ADN.
• Pueden formar heterodímeros y homodímeros entre las isoformas A y B.

Efectos fisiológicos

• Estimulan la actividad de la lipoproteína lipasa y favorecen el depósito de grasa.
• ↑ Niveles de insulina basal y respuesta de la insulina a la glucosa
• Promueven el almacenamiento de glucógeno en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el hígado, posiblemente al AL Amyloidosis facilitar el efecto sobre la insulina.
• Promueven la cetogénesis.
• ↑ Secreción de aldosterona por la corteza suprarrenal
• ↑ Temperatura corporal
• Afectan el estado de ánimo y el sueño (efecto hipnótico).
• Responsables del desarrollo del aparato secretor en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la mama.
• Participan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el aumento preovulatorio de la hormona luteinizante ( LH LH A major gonadotropin secreted by the adenohypophysis. Luteinizing hormone regulates steroid production by the interstitial cells of the testis and the ovary. The preovulatory luteinizing hormone surge in females induces ovulation, and subsequent luteinization of the follicle. Luteinizing hormone consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. Menstrual Cycle).
• Provocan la maduración y los LOS Neisseria cambios secretores en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el endometrio que se observan después de la ovulación.

Farmacocinética

• Formulaciones disponibles:
  • Oral
  • Implante (Nexplanon)
  • Inyección ( Depo-Provera Depo-Provera A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms. Hormonal Contraceptives)
  • Intrauterino (e.g., en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum dispositivos intrauterinos (DIU))
  • Parche transdérmico
  • Gel vaginal
• Absorción: rápida tras la administración por cualquier vía
• Distribución: 95% unido a la albúmina sérica
• Metabolismo:
  • Completo metabolismo en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum un paso por el hígado
  • La progesterona se metaboliza a pregnanediol y se conjuga con ácido glucurónico.
• Excreción:
  • Principalmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la orina
  • 10% en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum heces
• Vida media: 16–18 horas

Indicaciones

• Terapia hormonal para la menopausia:
  • Se utilizan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum combinación con estrógenos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres con útero intacto para prevenir la hiperplasia endometrial y el carcinoma causados por la terapia de reemplazo de estrógenos sin oposición.
  • Ocasionalmente se utilizan para los LOS Neisseria síntomas de la menopausia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum mujeres que no pueden tomar estrógenos.
• Para la supresión ovárica a largo plazo que causa anovulación prolongada y amenorrea en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el tratamiento de:
  • Dismenorrea
  • Endometriosis Endometriosis Endometriosis is a common disease in which patients have endometrial tissue implanted outside of the uterus. Endometrial implants can occur anywhere in the pelvis, including the ovaries, the broad and uterosacral ligaments, the pelvic peritoneum, and the urinary and gastrointestinal tracts. Endometriosis
  • Trastornos hemorrágicos

Efectos secundarios

• Hipertensión
• Dolor Dolor Inflammation torácico
• Sensibilidad e hipertrofia mamaria
• Dolor Dolor Inflammation abdominal
• Distensión abdominal
• Estreñimiento
• Somnolencia
• Mareo
• Cefalea
• Irritabilidad
• Depresión
• Sangrado vaginal irregular

Contraindicaciones

• Antecedentes o trastornos tromboembólicos existentes
• Carcinoma de mama o útero
• Disfunción hepática

Interacciones farmacológicas

• Progestinas ↓ efecto terapéutico:
  • Agentes antidiabéticos
  • Ulipristal Ulipristal Antiprogestins and Selective Progesterone Modulators: modulador selectivo del receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell. Receptors de progesterona utilizado como anticonceptivo de emergencia mediante la inhibición de la LH LH A major gonadotropin secreted by the adenohypophysis. Luteinizing hormone regulates steroid production by the interstitial cells of the testis and the ovary. The preovulatory luteinizing hormone surge in females induces ovulation, and subsequent luteinization of the follicle. Luteinizing hormone consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity. Menstrual Cycle y el retraso ovulatorio
  • Sincalida: agente de diagnóstico utilizado para imagenología gastrointestinal
• ↓ Efecto terapéutico de las progestinas:
  • Ulipristal Ulipristal Antiprogestins and Selective Progesterone Modulators
  • Agentes antifúngicos

Comparación de Medicamentos Estrogénicos y Progesterona/Progestinas