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Colitis Pseudomembranosa

La colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis pseudomembranosa es una inflamación del colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy causada por un crecimiento excesivo de la bacteria Bacteria Bacteria are prokaryotic single-celled microorganisms that are metabolically active and divide by binary fission. Some of these organisms play a significant role in the pathogenesis of diseases. Bacteriology Clostridioides difficile. Esta afección está asociada al AL Amyloidosis uso de antibióticos y a la consiguiente alteración de la microbiota colónica normal. Es una de las infecciones asociadas a la asistencia sanitaria más comunes y una causa importante de morbilidad y mortalidad, especialmente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum adultos mayores hospitalizados. Las manifestaciones clínicas de la infección por C. difficile incluyen colonización asintomática, enfermedad diarreica y colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis fulminante con sepsis Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by hypotension despite adequate fluid infusion, it is called septic shock. Sepsis and Septic Shock en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria casos graves. El diagnóstico se establece a partir de estudios de heces. La mayoría de los LOS Neisseria pacientes pueden tratarse con antibióticos. El trasplante fecal se considera en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum unos pocos casos, mientras que la intervención quirúrgica puede ser necesaria en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria casos graves.

Last updated: Dec 15, 2025

Editorial responsibility: Stanley Oiseth, Lindsay Jones, Evelin Maza

Descripción General

Definición

La colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis pseudomembranosa es una inflamación del colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy causada por el crecimiento excesivo de la bacteria Bacteria Bacteria are prokaryotic single-celled microorganisms that are metabolically active and divide by binary fission. Some of these organisms play a significant role in the pathogenesis of diseases. Bacteriology Clostridioides difficile.

Epidemiología

  • Es responsable de hasta 3 millones de casos de diarrea y colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum Estados Unidos cada año
  • Aproximadamente 14 000 muertes al AL Amyloidosis año en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum Estados Unidos
  • La mayoría de los LOS Neisseria casos son de origen hospitalario.
  • Hasta el 40% de los LOS Neisseria casos de colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis por C. difficile se adquieren en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la comunidad.

Etiología

  • Causada por cepas toxigénicas de C. difficile:
    • Bacilo grampositivo, anaerobio obligado
    • C. difficile puede existir en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum 2 formas:
      • Forma de espora: fuera del colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy; resistente al AL Amyloidosis calor Calor Inflammation, al AL Amyloidosis ácido y a los LOS Neisseria antibióticos
      • Forma vegetativa: en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el intestino
    • Muy contagioso
    • Esporas transmitidas por vía fecal-oral
  • El tratamiento antibiótico reciente es el principal factor de riesgo. Antibióticos más comúnmente implicados:
    • Clindamicina
    • Cefalosporinas
    • Fluoroquinolonas
    • Ampicilina
  • Otros factores de riesgo:
    • Inhibidores de la bomba de protones (supresión del ácido gástrico)
    • Edad avanzada > 65 años
    • Comorbilidades médicas
    • Hospitalización
    • Cirugía gastrointestinal
    • Alimentación enteral
    • Obesidad
    • Quimioterapia
    • Trasplante de células madre hematopoyéticas
    • Enfermedad inflamatoria intestinal
    • Cirrosis

Fisiopatología y Presentación Clínica

Patogénesis

  • El 2%–3% de los LOS Neisseria adultos sanos están colonizados por C. difficile.
  • El 8%–10% de los LOS Neisseria adultos hospitalizados están colonizados.
  • La alteración de la flora normal mediante el uso de antibióticos conduce al AL Amyloidosis crecimiento excesivo de C. difficile.
  • La mayoría de las infecciones clínicas se observan en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum pacientes recién colonizados.
  • El daño intestinal se debe a la liberación de toxinas.
  • Toxinas liberadas por C. difficile:
    • Enterotoxina A:
      • Se dirige a las enzimas del borde en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cepillo
      • Altera la secreción de líquidos
      • Causa diarrea acuosa
    • Toxina B (10 veces más potente):
      • Despolimeriza la actina
      • Altera el citoesqueleto de los LOS Neisseria enterocitos
      • Causa colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis pseudomembranosa

Presentación clínica

  • Diarrea maloliente sin sangre
  • Dolor Dolor Inflammation abdominal tipo cólico
  • Fiebre, náuseas y vómitos
  • Deshidratación
  • Leucocitosis
  • Colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis fulminante:
    • Distensión y dolor Dolor Inflammation abdominal agudo
    • Signos de sepsis Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by hypotension despite adequate fluid infusion, it is called septic shock. Sepsis and Septic Shock:
      • Hipotensión
      • Taquicardia
      • Cambio en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el estado mental
    • La diarrea puede estar ausente en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum este momento debido al AL Amyloidosis desarrollo del íleo colónico.
    • Megacolon Megacolon Megacolon is a severe, abnormal dilatation of the colon, and is classified as acute or chronic. There are many etiologies of megacolon, including neuropathic and dysmotility conditions, severe infections, ischemia, and inflammatory bowel disease. Megacolon tóxico:
      • Dilatación del intestino grueso > 7 cm; ciego > 12 cm
      • Toxicidad sistémica
    • Puede producirse perforación colónica, isquemia y necrosis Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply. Ischemic Cell Damage.
Tabla: Clasificación de la infección por C. difficile en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum función de la gravedad
Características Colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis leve a moderada Colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis severa Colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis fulminante
Número de deposiciones sueltas/día < 6 ≥ 6 ≥ 6
Fiebre +/– +/–
Conteo de leucocitos < 15 000/µL > 15 000/µL > 15 000/µL
Dolor Dolor Inflammation abdominal severo + +
Aumento de los LOS Neisseria niveles de creatinina +/– +/–
Disfunción multiorgánica +
Íleo completo o megacolon Megacolon Megacolon is a severe, abnormal dilatation of the colon, and is classified as acute or chronic. There are many etiologies of megacolon, including neuropathic and dysmotility conditions, severe infections, ischemia, and inflammatory bowel disease. Megacolon tóxico +
Signos radiológicos de colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis, íleo o megacolon Megacolon Megacolon is a severe, abnormal dilatation of the colon, and is classified as acute or chronic. There are many etiologies of megacolon, including neuropathic and dysmotility conditions, severe infections, ischemia, and inflammatory bowel disease. Megacolon tóxico +/– +
Adaptado de: Courtney Cassella. (2016). Imaging in Clostridium difficile infection. Retrieved February 8, 2021, from https://sinaiem.org/imaging-in-clostridium-difficile-infection/

Diagnóstico

Antecedentes clínicos

  • Inicio agudo de diarrea sin otras explicaciones
  • Tratamiento con antibióticos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria últimos 6 meses
  • Hospitalización
  • Cirugía abdominal reciente
  • Enfermedades crónicas

Examen físico

  • Los LOS Neisseria hallazgos son mínimos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria casos leves
  • Colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis severa:
    • Sensibilidad/distensión abdominal difusa
    • Signos de deshidratación/ sepsis Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by hypotension despite adequate fluid infusion, it is called septic shock. Sepsis and Septic Shock: taquicardia, hipotensión, fiebre, baja producción de orina

Estudios de laboratorio

  • Estudios de heces:
    • Reacción en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cadena de la polimerasa ( PCR PCR Polymerase chain reaction (PCR) is a technique that amplifies DNA fragments exponentially for analysis. The process is highly specific, allowing for the targeting of specific genomic sequences, even with minuscule sample amounts. The PCR cycles multiple times through 3 phases: denaturation of the template DNA, annealing of a specific primer to the individual DNA strands, and synthesis/elongation of new DNA molecules. Polymerase Chain Reaction (PCR), por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) para los LOS Neisseria genes Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. DNA Types and Structure de C. difficile
    • Inmunoensayo enzimático para el antígeno de C. difficile (rápido, ampliamente disponible)
    • Inmunoensayo enzimático para las toxinas A y B de C. difficile
  • Análisis de sangre:
    • Leucocitosis o leucopenia
    • Hipocalemia (debido a la diarrea)
    • Hallazgos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis fulminante:
      • Creatinina sérica > 1,5 (posible lesión renal causada por la deshidratación)
      • ↑ Niveles de lactato
      • Albúmina sérica < 2,5 g/dL
      • Bandemia

Imagenología

  • Radiografía de abdomen:
    • Puede mostrar dilatación colónica
    • Aire libre en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum caso de perforación
  • Tomografía computarizada (TC):
    • Puede detectar colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis, íleo o megacolon Megacolon Megacolon is a severe, abnormal dilatation of the colon, and is classified as acute or chronic. There are many etiologies of megacolon, including neuropathic and dysmotility conditions, severe infections, ischemia, and inflammatory bowel disease. Megacolon tóxico
    • Puede revelar complicaciones como la perforación
    • Hallazgos de colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis pseudomembranosa:
      • “Signo del acordeón” (con contraste administrado por vía oral; edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema e inflamación de la mucosa)
      • “Signo de la diana”, “signo del doble halo”: signos de edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema de la mucosa
      • Engrosamiento de la pared del colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy
      • Heterogeneidad pericolónica
      • Ascitis
Tomografía computarizada de colitis pseudomembranosa

Tomografía computarizada de colitis pseudomembranosa grave: engrosamiento difuso de la pared del colon, con áreas sugestivas de hemorragia de la mucosa

Imagen: “Abdominal computer tomography” por Division of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, New Territories, Hong Kong. Licencia: CC BY 4.0

Sigmoidoscopia flexible

  • No es necesaria si el diagnóstico se confirma en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum base a los LOS Neisseria estudios de heces
  • Solo es necesaria si se considera un diagnóstico alternativo
  • No se recomienda la colonoscopia completa por el riesgo de perforación.
  • Hallazgos:
    • Eritema
    • Mucosa friable
    • Edema Edema Edema is a condition in which excess serous fluid accumulates in the body cavity or interstitial space of connective tissues. Edema is a symptom observed in several medical conditions. It can be categorized into 2 types, namely, peripheral (in the extremities) and internal (in an organ or body cavity). Edema de la pared intestinal
    • Pseudomembranas:
      • Placas elevadas de color amarillo o blanquecino de hasta 2 cm de diámetro
      • Se forman como resultado de la ulceración de la mucosa

Tratamiento

Tratamiento de la infección por C. difficile

Algoritmo para el tratamiento de las infecciones por C. difficile. Cr: creatinina, IV: intravenosa

Imagen por Lecturio.

Tratamiento médico

  • Reanimación intravenosa, corrección de electrolitos
  • Si es posible, suspender el antibiótico que lo provoca.
  • Las opciones de terapia antibiótica incluyen:
    • Fidaxomicina oral
    • Vancomicina oral
    • Vancomicina rectal para pacientes con íleo pronunciado
    • Metronidazol oral o intravenoso
    • Bezlotoxumab para prevenir la recurrencia en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum personas con alto riesgo
  • Transplante fecal:
    • Como alternativa a la cirugía en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum caso de colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis fulminante
    • Para la infección por C. difficile recurrente
    • Para pacientes que no han respondido a al AL Amyloidosis menos 2 regímenes antibióticos adecuados

Cirugía

Posibles indicaciones:

  • Hipotensión
  • Fiebre > 38,5ºC (101,3ºF)
  • Distensión abdominal significativa
  • Peritonitis Peritonitis Inflammation of the peritoneum lining the abdominal cavity as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the peritoneal cavity via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the abdominal cavity itself through rupture or abscess of intra-abdominal organs. Penetrating Abdominal Injury
  • Alteración del estado mental
  • Lactato sérico > 2,2 mmol/L
  • Leucocitosis > 20 000 células/mL
  • Ingreso en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la unidad de cuidados intensivos
  • No mejora con el tratamiento médico
  • Perforación del colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy

Intervenciones quirúrgicas:

  • Colectomía abdominal total con ileostomía terminal
  • La colectomía segmentaria no suele ser recomendable.
  • Alternativa a la colectomía:

Prevención de la transmisión hospitalaria

  • Guantes del personal
  • Aislamiento del paciente con instalaciones de baño designadas
  • Evitar el uso de termómetros y estetoscopios electrónicos contaminados
  • Uso de solución de hipoclorito (lejía) para descontaminar las habitaciones de los LOS Neisseria pacientes
  • Lavado de manos con jabón ( los LOS Neisseria geles de manos que contienen alcohol no son esporicidas)
  • Restringir el uso de antibióticos específicos:
    • Clindamicina
    • Cefalosporinas de 2da y 3ra generación

Pronóstico

  • Hasta el 25% de los LOS Neisseria pacientes experimentarán una recidiva en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum los LOS Neisseria 30 días siguientes a la finalización del tratamiento.
  • Los LOS Neisseria pacientes que experimentan una recidiva tienen un mayor riesgo de volver a sufrirla.
  • La mortalidad global de la colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis pseudomembranosa es del 4,9%–6,2%.

Diagnóstico Diferencial

  • Enfermedad de Crohn: condición crónica y recurrente que provoca una inflamación transmural en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum parches en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el íleon terminal y el colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy proximal. Los LOS Neisseria pacientes con enfermedad de Crohn suelen presentar diarrea intermitente no sanguinolenta y dolor Dolor Inflammation abdominal tipo cólico. El tratamiento es con corticosteroides, azatioprina, antibióticos y agentes contra el factor de necrosis Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply. Ischemic Cell Damage tumoral ( TNF TNF Tumor necrosis factor (TNF) is a major cytokine, released primarily by macrophages in response to stimuli. The presence of microbial products and dead cells and injury are among the stimulating factors. This protein belongs to the TNF superfamily, a group of ligands and receptors performing functions in inflammatory response, morphogenesis, and cell proliferation. Tumor Necrosis Factor (TNF), por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés). Las complicaciones incluyen la malabsorción, la obstrucción intestinal o la fístula, y un mayor riesgo de cáncer de colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy.
  • Colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis ulcerosa: enfermedad inflamatoria idiopática que afecta a la superficie de la mucosa del colon Colon The large intestines constitute the last portion of the digestive system. The large intestine consists of the cecum, appendix, colon (with ascending, transverse, descending, and sigmoid segments), rectum, and anal canal. The primary function of the colon is to remove water and compact the stool prior to expulsion from the body via the rectum and anal canal. Colon, Cecum, and Appendix: Anatomy. En EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum la colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis ulcerosa se observa friabilidad difusa de la mucosa, erosiones con hemorragia y pérdida de haustras. Los LOS Neisseria pacientes presentan diarrea sanguinolenta, dolor Dolor Inflammation abdominal tipo cólico, tenesmo y urgencia fecal. El diagnóstico se establece a partir de una endoscopia con biopsia. El tratamiento es con mesalamina tópica o 6-mercaptopurina, o colectomía para los LOS Neisseria casos graves.
  • Diarrea infecciosa ( Staphylococcus aureus Staphylococcus aureus Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications. Brain Abscess, Klebsiella oxytoca Klebsiella Oxytoca Multidrug-resistant Organisms and Nosocomial Infections, Clostridium perfringens Clostridium perfringens The most common etiologic agent of gas gangrene. It is differentiable into several distinct types based on the distribution of twelve different toxins. Gas Gangrene y Salmonella Salmonella Salmonellae are gram-negative bacilli of the family Enterobacteriaceae. Salmonellae are flagellated, non-lactose-fermenting, and hydrogen sulfide-producing microbes. Salmonella enterica, the most common disease-causing species in humans, is further classified based on serotype as typhoidal (S. typhi and paratyphi) and nontyphoidal (S. enteritidis and typhimurium). Salmonella): se presenta con manifestaciones clínicas similares a las de las infecciones por C. difficile. El diagnóstico se distingue con base en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum el coprocultivo. El tratamiento es principalmente de soporte y requiere el uso de antibióticos en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum algunos casos.
  • Escherichia coli Escherichia coli The gram-negative bacterium Escherichia coli is a key component of the human gut microbiota. Most strains of E. coli are avirulent, but occasionally they escape the GI tract, infecting the urinary tract and other sites. Less common strains of E. coli are able to cause disease within the GI tract, most commonly presenting as abdominal pain and diarrhea. Escherichia coli diarreogénica: causa enteritis Enteritis Inflammation of any segment of the small intestine. Lactose Intolerance, enterocolitis Enterocolitis Inflammation of the mucosa of both the small intestine and the large intestine. Etiology includes ischemia, infections, allergic, and immune responses. Yersinia spp./Yersiniosis y colitis Colitis Inflammation of the colon section of the large intestine, usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever. Pseudomembranous Colitis. Los LOS Neisseria pacientes suelen presentar diarrea acuosa/sanguinolenta, vómitos y fiebre. El diagnóstico se establece a partir del cultivo y/o la reacción en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum cadena de la polimerasa ( PCR PCR Polymerase chain reaction (PCR) is a technique that amplifies DNA fragments exponentially for analysis. The process is highly specific, allowing for the targeting of specific genomic sequences, even with minuscule sample amounts. The PCR cycles multiple times through 3 phases: denaturation of the template DNA, annealing of a specific primer to the individual DNA strands, and synthesis/elongation of new DNA molecules. Polymerase Chain Reaction (PCR), por sus siglas en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum inglés) con muestras de heces. El tratamiento consiste en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum una terapia de soporte (líquidos y electrolitos). Aunque los LOS Neisseria antibióticos se reservan para los LOS Neisseria casos graves/persistentes, están contraindicados en EN Erythema nodosum is an immune-mediated panniculitis (inflammation of the subcutaneous fat) caused by a type IV (delayed-type) hypersensitivity reaction. It commonly manifests in young women as tender, erythematous nodules on the shins. Erythema Nodosum algunos casos.

Referencias

  1. Aberra F.N. (2019). Clostridioides (Clostridium) difficile colitis. Retrieved 29 January 2021, from https://emedicine.medscape.com/article/186458-overview#a6
  2. Ananthakrishnan A.N. Clostridium difficile infection: Epidemiology, risk factors and management. Nat Rev Gastroenterol Hepatol. 2011 Jan. 8(1):17-26.
  3. Cohen S.H., Gerding D.N., Johnson S., et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010 May. 31(5):431-55.
  4. Kelly C.P., Lamont J.T., Bakken J.S. (2021). Clostridioides (formerly Clostridium) difficile infection in adults: Treatment and prevention. Retrieved 29 January 2021, from https://www.uptodate.com/contents/clostridioides-formerly-clostridium-difficile-infection-in-adults-treatment-and-prevention
  5. Lamont J.T., Kelly C.P., Bakken J.S. (2020). Clostridioides (formerly Clostridium) difficile infection in adults: Clinical manifestations and diagnosis. Retrieved 21 January 2021, from https://www.uptodate.com/contents/clostridioides-formerly-clostridium-difficile-infection-in-adults-clinical-manifestations-and-diagnosis
  6. McDonald L.C., Coignard B., Dubberke E., Song X., Horan T., Kutty P.K. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol. 2007 Feb. 28(2):140-5.
  7. Pant C., Sferra T.J., Deshpande A., Minocha A. Clinical approach to severe Clostridium difficile infection: Update for the hospital practitioner. Eur J Intern Med. 2011;22(6):561-8.

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