Pharmacokinetics Pharmacodynamics

by Adam Le Gresley, PhD

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    Okay. So, in the previous lectures, we looked at receptors and also enzymes. And now, what I would like to do is consider the journey that a drug makes; breaking down the different parts of the journey of a drug into the different phases: the pharmaceutical phase, the pharmacokinetic phase and also, the pharmacodynamic phase. In the pharmaceutical phase, a drug is disintegrated from its dosage form by dissolution of the active substrate. Pharmacokinetically, it is then either absorbed, then distributed, metabolised and excreted. The pharmacodynamic phase pertains directly to the efficacy of the drug receptor interaction, specifically in the target tissue. When we consider the purpose of the pharmaceutical phase, this is to optimise the pharmaceutical availability, making sure that there is drug available for absorption in the first place. Within the pharmacokinetic phase, optimisation of biological availability i.e. for example, a drug’s availability to be absorbed and also, to travel to the right tissue where it is supposed to function. And finally, the pharmacodynamic phase, the objective, of course, to optimise the required biological effect which is the induction of therapeutic effect. In other words, time to reduce the amount of material we are actually need to achieve a desired effect without causing damage to surrounding tissues or interfering with other receptors. The pharmacokinetic phase for the drug to be useful. The compound with the best binding affinity for a target is not necessarily the best drug. And indeed, it may actually show poor activity in vivo. There are many instances of this. For a drug to be useful, it must first reach the target site. It must be absorbed in sufficient quantity, distributed correctly into the target tissue and should not be metabolised too quickly or extensively, for example, via first-pass metabolism in the liver. We need...

    About the Lecture

    The lecture Pharmacokinetics Pharmacodynamics by Adam Le Gresley, PhD is from the course Medical Chemistry. It contains the following chapters:

    • Pharmacokinetics pharmacodynamics
    • Lipophilicity
    • Acid sensitivity
    • BBB penetration

    Included Quiz Questions

    1. the ratio of the concentration of a drug between two immiscible solvents.
    2. the ratio of the concentration of a drug between two partially miscible solvents
    3. the ratio of the concentration of a drug between the cell membrane and the lipid bilayer.
    4. the ratio of the concentration of a drug between ethanol and water.
    5. None of the above

    Author of lecture Pharmacokinetics Pharmacodynamics

     Adam Le Gresley, PhD

    Adam Le Gresley, PhD

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